Role of genomic instability and p53 in AID-induced c-myc–Igh translocations

Chromosomal translocations involving the immunoglobulin switch region are a hallmark feature of B-cell malignancies 1 . However, little is known about the molecular mechanism by which primary B cells acquire or guard against these lesions. Here we find that translocations between c-myc and the IgH l...

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Veröffentlicht in:	Nature Jg. 440; H. 7080; S. 105 - 109
Hauptverfasser:	Ramiro, Almudena R., Jankovic, Mila, Callen, Elsa, Difilippantonio, Simone, Chen, Hua-Tang, McBride, Kevin M., Eisenreich, Thomas R., Chen, Junjie, Dickins, Ross A., Lowe, Scott W., Nussenzweig, Andre, Nussenzweig, Michel C.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 02.03.2006 Nature Publishing Group
Schlagworte:	Acquired immune deficiency syndrome AIDS Animals B-Lymphocytes - metabolism Cancer Cell Line Cells Chromosomes Cytidine Deaminase - genetics Cytidine Deaminase - metabolism Deoxyribonucleic acid Development and progression DNA DNA damage DNA Damage - genetics Enzymes Gene Expression Genes, Immunoglobulin Heavy Chain - genetics Genes, myc - genetics Genetic aspects Genetic research Genomic Instability - genetics Genomics Health aspects Humanities and Social Sciences Hydrolases Immunoglobulin Class Switching - genetics Immunoglobulins Lesions letter Lymphocytic leukemia Mice Models, Genetic multidisciplinary Mutation - genetics Physiology Science Science (multidisciplinary) Translocation Translocation, Genetic - genetics Translocations (Genetics) Tumor proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors United States
ISSN:	0028-0836, 1476-4687, 1476-4687, 1476-4679
Online-Zugang:	Volltext
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