Chemico-genetic discovery of astrocytic control of inhibition in vivo

Perisynaptic astrocytic processes are an integral part of central nervous system synapses 1 , 2 ; however, the molecular mechanisms that govern astrocyte–synapse adhesions and how astrocyte contacts control synapse formation and function are largely unknown. Here we use an in vivo chemico-genetic ap...

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Bibliographic Details
Published in:	Nature (London) Vol. 588; no. 7837; pp. 296 - 302
Main Authors:	Takano, Tetsuya, Wallace, John T., Baldwin, Katherine T., Purkey, Alicia M., Uezu, Akiyoshi, Courtland, Jamie L., Soderblom, Erik J., Shimogori, Tomomi, Maness, Patricia F., Eroglu, Cagla, Soderling, Scott H.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10.12.2020 Nature Publishing Group
Subjects:	13 13/106 14 14/19 631/378/2571/2577 631/378/2596/1308 631/378/87 82 82/58 Analysis Animals Astrocytes Astrocytes - chemistry Astrocytes - cytology Astrocytes - metabolism Cell adhesion Cell adhesion & migration Cell adhesion molecules Cell Adhesion Molecules, Neuronal - metabolism Cell Shape Cell surface Central nervous system Chemical properties Complementation Control CRISPR Depletion Female GABAergic Neurons - cytology GABAergic Neurons - metabolism gamma-Aminobutyric Acid - metabolism Genetic aspects Genetic Complementation Test Gephyrin Glutamatergic transmission HEK293 Cells Humanities and Social Sciences Humans Inhibition (Neurophysiology) Male Mice Molecular modelling Morphogenesis multidisciplinary Nervous system Neural Inhibition Neurons Neurons - cytology Neurons - metabolism Neuropil Proteins Proteome - metabolism Proteomes Proteomics Science Science (multidisciplinary) Synapses Synapses - chemistry Synapses - metabolism Synaptic density Synaptogenesis γ-Aminobutyric acid United States
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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