Coherent encoding of subjective spatial position in visual cortex and hippocampus

A major role of vision is to guide navigation, and navigation is strongly driven by vision 1 – 4 . Indeed, the brain’s visual and navigational systems are known to interact 5 , 6 , and signals related to position in the environment have been suggested to appear as early as in the visual cortex 6 , 7...

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Vydané v:	Nature (London) Ročník 562; číslo 7725; s. 124 - 127
Hlavní autori:	Saleem, Aman B., Diamanti, E. Mika, Fournier, Julien, Harris, Kenneth D., Carandini, Matteo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 01.10.2018 Nature Publishing Group
Predmet:	14/69 631/378/116 631/378/1595/3922 631/378/2613 631/378/3917 631/378/3920 64/110 64/60 Animals Brain Brain research Coding Computer applications Female Hippocampus Hippocampus (Brain) Hippocampus - cytology Hippocampus - physiology Humanities and Social Sciences Information processing Landmarks Letter Life Sciences Male Mice Mice, Inbred C57BL Modulation multidisciplinary Navigation Navigation behavior Neurons Neurons - physiology Neurons and Cognition Populations Reinforcement Representations Reward Science Science (multidisciplinary) Sensory integration Somatosensory cortex Space perception Spatial Behavior - physiology Spatial Processing - physiology Virtual Reality Visual cortex Visual Cortex - cytology Visual Cortex - physiology Visual signals Reward Zone Reward Regions Pupil Position Water Reward Running Speed
ISSN:	0028-0836, 1476-4687, 1476-4687
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Shrnutí:	A major role of vision is to guide navigation, and navigation is strongly driven by vision 1 – 4 . Indeed, the brain’s visual and navigational systems are known to interact 5 , 6 , and signals related to position in the environment have been suggested to appear as early as in the visual cortex 6 , 7 . Here, to establish the nature of these signals, we recorded in the primary visual cortex (V1) and hippocampal area CA1 while mice traversed a corridor in virtual reality. The corridor contained identical visual landmarks in two positions, so that a purely visual neuron would respond similarly at those positions. Most V1 neurons, however, responded solely or more strongly to the landmarks in one position rather than the other. This modulation of visual responses by spatial location was not explained by factors such as running speed. To assess whether the modulation is related to navigational signals and to the animal’s subjective estimate of position, we trained the mice to lick for a water reward upon reaching a reward zone in the corridor. Neuronal populations in both CA1 and V1 encoded the animal’s position along the corridor, and the errors in their representations were correlated. Moreover, both representations reflected the animal’s subjective estimate of position, inferred from the animal’s licks, better than its actual position. When animals licked in a given location—whether correctly or incorrectly—neural populations in both V1 and CA1 placed the animal in the reward zone. We conclude that visual responses in V1 are controlled by navigational signals, which are coherent with those encoded in hippocampus and reflect the animal’s subjective position. The presence of such navigational signals as early as a primary sensory area suggests that they permeate sensory processing in the cortex. When running through a virtual reality corridor, a mouse’s position is represented in both the hippocampus (as expected) and the primary visual cortex, for places that are visually identical.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors jointly supervised this work.
ISSN:	0028-0836 1476-4687 1476-4687
DOI:	10.1038/s41586-018-0516-1