Safety of single-dose bedaquiline combined with rifampicin for leprosy post-exposure prophylaxis: A Phase 2 randomized non-inferiority trial in the Comoros Islands

To reduce leprosy risk in contacts of patients with leprosy by around 50%, the World Health Organization (WHO) recommends leprosy post-exposure prophylaxis (PEP) using single-dose rifampicin (SDR). Results from a cluster randomized trial in the Comoros and Madagascar suggest that PEP with a double d...

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Bibliographic Details
Published in:	PLoS medicine Vol. 21; no. 10; p. e1004453
Main Authors:	de Jong, Bouke Catherine, Nourdine, Said, Bergeman, Auke Thomas, Salim, Zahara, Grillone, Silahi Halifa, Braet, Sofie Marijke, Wirdane Abdou, Mohamed, Snijders, Rian, Ronse, Maya, Hoof, Carolien, Tsoumanis, Achilleas, Ortuño-Gutiérrez, Nimer, der Werf, Christian van, Piubello, Alberto, Mzembaba, Aboubacar, Assoumani, Younoussa, Hasker, Epco
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 21.10.2024 Public Library of Science (PLoS)
Subjects:	Children Collaboration Data collection Diarrhea Disease prevention Dosage and administration Drug dosages Drug therapy Drug therapy, Combination EKG Electrocardiogram Electrocardiography Enzymes Heart rate Leprosy Liver Medicine and Health Sciences Pediatrics Pharmaceuticals Pharmacology, Experimental Physiological aspects Prophylaxis Research and Analysis Methods Rifampin Testing Tuberculosis Belgium Bangladesh Madagascar Comoro Islands
ISSN:	1549-1676, 1549-1277, 1549-1676
Online Access:	Get full text
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