Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study

Earlier puberty is widely linked with future obesity and cardiometabolic disease. We examined whether age at puberty onset likely influences adiposity and cardiometabolic traits independent of childhood adiposity. One-sample Mendelian randomisation (MR) analyses were conducted on up to 3,611 white-E...

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Bibliographic Details
Published in:	PLoS medicine Vol. 15; no. 8; p. e1002641
Main Authors:	Bell, Joshua A., Carslake, David, Wade, Kaitlin H., Richmond, Rebecca C., Langdon, Ryan J., Vincent, Emma E., Holmes, Michael V., Timpson, Nicholas J., Davey Smith, George
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 28.08.2018 Public Library of Science (PLoS)
Subjects:	Absorptiometry, Photon Adipose tissue Adiposity Adolescent Age Age Factors Amino acids Amino Acids - metabolism Biology and Life Sciences Blood Pressure Body Composition Body mass Body Mass Index Cardiovascular disease Children Cholesterol Cholesterol, HDL - metabolism Cholesterol, LDL - metabolism Cohort Studies Dual energy X-ray absorptiometry England - epidemiology Epidemiology Error analysis Exposure Fatty Acids - metabolism Female Females Genome-wide association studies Genomes Glycoproteins Growth factors Health aspects Health risk assessment Humans Inflammation Insulin Insulin-like growth factors Ketones - metabolism Magnetic Resonance Spectroscopy Male Males Medical research Medicine and Health Sciences Menarche Mendelian Randomization Analysis Metabolic diseases Metabolomics NMR Nuclear magnetic resonance Obesity Offspring Pediatric diseases Pediatric Obesity - epidemiology Pediatric Obesity - metabolism Phenotype Puberty Randomization Risk factors Spectroscopy Systematic review Triglycerides White People Womens health England United Kingdom > UK
ISSN:	1549-1676, 1549-1277, 1549-1676
Online Access:	Get full text
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