Functional Heterogeneity of Embryonic Stem Cells Revealed through Translational Amplification of an Early Endodermal Transcript

ES cells are defined as self-renewing, pluripotent cell lines derived from early embryos. Cultures of ES cells are also characterized by the expression of certain markers thought to represent the pluripotent state. However, despite the widespread expression of key markers such as Oct4 and the appear...

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Bibliographic Details
Published in:	PLoS biology Vol. 8; no. 5; p. e1000379
Main Authors:	Canham, Maurice A., Sharov, Alexei A., Ko, Minoru S. H., Brickman, Joshua M.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.05.2010 Public Library of Science (PLoS)
Subjects:	Animals Biomarkers - metabolism Blastocyst - cytology Blastocyst - metabolism Cell Biology/Cell Signaling Cell Biology/Developmental Molecular Mechanisms Cell Biology/Gene Expression Cell culture Cell Differentiation - genetics Cell Differentiation - physiology Cell Lineage Cells, Cultured Cellular biology Chimeras (Organisms) Developmental Biology/Cell Differentiation Developmental Biology/Stem Cells Embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - physiology Embryos Endoderm - cytology Endoderm - metabolism Endoderm - physiology Flow cytometry Gene expression Gene Expression Regulation, Developmental Genetic aspects Genetics and Genomics/Gene Expression Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Lewis X Antigen - genetics Lewis X Antigen - metabolism Luminescent Proteins - genetics Luminescent Proteins - metabolism Mice Morula Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Ontology Population Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Stem cells Transcription Factors - genetics Transcription Factors - metabolism Transgenes United States United Kingdom Octamer Transcription Factor-3 Antigens, CD15 Biological Markers Blastocyst Cells, Cultured Morula Recombinant Fusion Proteins Cell Lineage Animals Gene Expression Regulation, Developmental Homeodomain Proteins Cell Differentiation Mice Transcription Factors Embryonic Stem Cells Transgenes Endoderm Luminescent Proteins
ISSN:	1545-7885, 1544-9173, 1545-7885
Online Access:	Get full text
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