Interactions among Polycomb Domains Are Guided by Chromosome Architecture

Polycomb group (PcG) proteins bind and regulate hundreds of genes. Previous evidence has suggested that long-range chromatin interactions may contribute to the regulation of PcG target genes. Here, we adapted the Chromosome Conformation Capture on Chip (4C) assay to systematically map chromosomal in...

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Bibliographic Details
Published in:	PLoS genetics Vol. 7; no. 3; p. e1001343
Main Authors:	Tolhuis, Bas, Blom, Marleen, Kerkhoven, Ron M., Pagie, Ludo, Teunissen, Hans, Nieuwland, Marja, Simonis, Marieke, de Laat, Wouter, van Lohuizen, Maarten, van Steensel, Bas
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.03.2011 Public Library of Science (PLoS)
Subjects:	Animals Architecture Brain - metabolism Cellular proteins Chromatin Chromatin - metabolism Chromosomes Chromosomes - chemistry Chromosomes - metabolism Chromosomes, Insect - chemistry Chromosomes, Insect - genetics Computational Biology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Gene Expression Profiling Gene Expression Regulation Genes, Homeobox - genetics Genetic aspects Genetics Genetics and Genomics/Chromosome Biology Genetics and Genomics/Epigenetics Genetics and Genomics/Nuclear Structure and Function Genomes Genomics Histones - metabolism Insects Larva Physiological aspects Polycomb-Group Proteins Protein Binding Proteins Repressor Proteins - chemistry Repressor Proteins - metabolism Netherlands
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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