Genome-Wide Association Analysis of Soluble ICAM-1 Concentration Reveals Novel Associations at the NFKBIK, PNPLA3, RELA, and SH2B3 Loci

Soluble ICAM-1 (sICAM-1) is an endothelium-derived inflammatory marker that has been associated with diverse conditions such as myocardial infarction, diabetes, stroke, and malaria. Despite evidence for a heritable component to sICAM-1 levels, few genetic loci have been identified so far. To compreh...

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Veröffentlicht in:	PLoS genetics Jg. 7; H. 4; S. e1001374
Hauptverfasser:	Paré, Guillaume, Ridker, Paul M., Rose, Lynda, Barbalic, Maja, Dupuis, Josée, Dehghan, Abbas, Bis, Joshua C., Benjamin, Emelia J., Shiffman, Dov, Parker, Alexander N., Chasman, Daniel I.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.04.2011 Public Library of Science (PLoS)
Schlagworte:	ABO Blood-Group System - genetics Adaptor Proteins, Signal Transducing Algorithms Cardiovascular Disorders/Coronary Artery Disease Cell adhesion molecules Charitable foundations Cohort Studies Diagnosis Disease Epidemiology Female Gene Frequency Genetic aspects Genetic Loci Genetics Genetics and Genomics/Complex Traits Genome, Human Genome-Wide Association Study Genomes Genotype Heart Heart attack Humans I-kappa B Kinase - genetics Immunology/Genetics of the Immune System Intercellular Adhesion Molecule-1 - blood Intercellular Adhesion Molecule-1 - genetics Intracellular Signaling Peptides and Proteins Lipase - genetics Liver diseases Membrane Proteins - genetics Models, Genetic Multifactorial Inheritance Physiological aspects Polymorphism, Single Nucleotide Proteins - genetics Single nucleotide polymorphisms Stroke Stroke (Disease) Transcription Factor RelA - genetics Womens health United States
ISSN:	1553-7404, 1553-7390, 1553-7404
Online-Zugang:	Volltext
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