ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy

Recent advances in the identification of susceptibility genes and environmental exposures provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin (orexin) deficiency. We genotyped loci associated with other autoimmune and inflammatory diseases in 1,886 individuals with...

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Bibliographic Details
Published in:	PLoS genetics Vol. 9; no. 2; p. e1003270
Main Authors:	Faraco, Juliette, Lin, Ling, Kornum, Birgitte Rahbek, Kenny, Eimear E., Trynka, Gosia, Einen, Mali, Rico, Tom J., Lichtner, Peter, Dauvilliers, Yves, Arnulf, Isabelle, Lecendreux, Michel, Javidi, Sirous, Geisler, Peter, Mayer, Geert, Pizza, Fabio, Poli, Francesca, Plazzi, Giuseppe, Overeem, Sebastiaan, Lammers, Gert Jan, Kemlink, David, Sonka, Karel, Nevsimalova, Sona, Rouleau, Guy, Desautels, Alex, Montplaisir, Jacques, Frauscher, Birgit, Ehrmann, Laura, Högl, Birgit, Jennum, Poul, Bourgin, Patrice, Peraita-Adrados, Rosa, Iranzo, Alex, Bassetti, Claudio, Chen, Wei-Min, Concannon, Patrick, Thompson, Susan D., Damotte, Vincent, Fontaine, Bertrand, Breban, Maxime, Gieger, Christian, Klopp, Norman, Deloukas, Panos, Wijmenga, Cisca, Hallmayer, Joachim, Onengut-Gumuscu, Suna, Rich, Stephen S., Winkelmann, Juliane, Mignot, Emmanuel
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.02.2013 Public Library of Science (PLoS)
Subjects:	Antigen Presentation - genetics Antigen Presentation - immunology Antigens Autoimmune diseases Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Biochemistry, Molecular Biology Biology Confidence intervals Disease Disease susceptibility European Continental Ancestry Group Gene expression Genealogy Genetic aspects Genetic Association Studies Genetics Genomes Grants Haplotypes Health aspects Health sciences HLA Antigens - genetics HLA Antigens - immunology Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - immunology Intracellular Signaling Peptides and Proteins - metabolism Life Sciences Lymphocytes Narcolepsy Narcolepsy - genetics Narcolepsy - immunology Narcolepsy - physiopathology Neuropeptides - genetics Neuropeptides - immunology Neuropeptides - metabolism Orexins Physiological aspects Principal components analysis Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - metabolism Sleep disorders T cell receptors T cells Netherlands Haplotypes Cytokines Europe Genetic loci T cell receptors Narcolepsy Autoimmune diseases T cells
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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