Nontuberculous Mycobacteria Infections at a Provincial Reference Hospital, Cambodia

Prevalence of nontuberculous mycobacteria (NTM) disease is poorly documented in countries with high prevalence of tuberculosis (TB). We describe prevalence, risk factors, and TB program implications for NTM isolates and disease in Cambodia. A prospective cohort of 1,183 patients with presumptive TB...

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Vydáno v:	Emerging infectious diseases Ročník 23; číslo 7; s. 1139 - 1147
Hlavní autoři:	Bonnet, Maryline, San, Kim Chamroeun, Pho, Yati, Sok, Chandara, Dousset, Jean-Philippe, Brant, William, Hurtado, Northan, Eam, Khun Kim, Ardizzoni, Elisa, Heng, Seiha, Godreuil, Sylvain, Yew, Wing-Wai, Hewison, Cathy
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States U.S. National Center for Infectious Diseases 01.07.2017 Centers for Disease Control and Prevention
Témata:	Adolescent Adult Aged Cambodia - epidemiology Coinfection Cross Infection Emerging diseases Female Health aspects HIV HIV Infections HIV patients Human health and pathology Humans Infectious diseases Life Sciences limited-resource countries Male Middle Aged Mycobacterium Infections, Nontuberculous - diagnosis Mycobacterium Infections, Nontuberculous - epidemiology Mycobacterium Infections, Nontuberculous - microbiology Mycobacterium Infections, Nontuberculous - therapy nontuberculous mycobacteria Nontuberculous Mycobacteria - isolation & purification Nontuberculous Mycobacteria Infections at a Provincial Reference Hospital, Cambodia NTM Population Surveillance Prevalence Prospective Studies Risk factors Santé publique et épidémiologie Tuberculosis tuberculosis and other mycobacteria Young Adult Cambodia France Southeast Asia Cambodia bacteria NTM infectious diseases limited-resource countries tuberculosis and other mycobacteria nontuberculous mycobacteria TB HIV Infections Coinfection Prevalence Prospective Studies Middle Aged Humans Cross Infection Male Mycobacterium Infections Young Adult Adolescent Nontuberculous Female Adult Aged Population Surveillance
ISSN:	1080-6040, 1080-6059, 1080-6059
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Shrnutí:	Prevalence of nontuberculous mycobacteria (NTM) disease is poorly documented in countries with high prevalence of tuberculosis (TB). We describe prevalence, risk factors, and TB program implications for NTM isolates and disease in Cambodia. A prospective cohort of 1,183 patients with presumptive TB underwent epidemiologic, clinical, radiologic, and microbiologic evaluation, including >12-months of follow-up for patients with NTM isolates. Prevalence of NTM isolates was 10.8% and of disease was 0.9%; 217 (18.3%) patients had TB. Of 197 smear-positive patients, 171 (86.8%) had TB confirmed (167 by culture and 4 by Xpert MTB/RIF assay only) and 11 (5.6%) had NTM isolates. HIV infection and past TB were independently associated with having NTM isolates. Improved detection of NTM isolates in Cambodia might require more systematic use of mycobacterial culture and the use of Xpert MTB/RIF to confirm smear-positive TB cases, especially in patients with HIV infection or a history of TB.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 PMCID: PMC5512507
ISSN:	1080-6040 1080-6059 1080-6059
DOI:	10.3201/eid2307.170060