The Contribution of GWAS Loci in Familial Dyslipidemias

Familial combined hyperlipidemia (FCH) is a complex and common familial dyslipidemia characterized by elevated total cholesterol and/or triglyceride levels with over five-fold risk of coronary heart disease. The genetic architecture and contribution of rare Mendelian and common variants to FCH susce...

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Bibliographic Details
Published in:	PLoS genetics Vol. 12; no. 5; p. e1006078
Main Authors:	Ripatti, Pietari, Rämö, Joel T., Söderlund, Sanni, Surakka, Ida, Matikainen, Niina, Pirinen, Matti, Pajukanta, Päivi, Sarin, Antti-Pekka, Service, Susan K., Laurila, Pirkka-Pekka, Ehnholm, Christian, Salomaa, Veikko, Wilson, Richard K., Palotie, Aarno, Freimer, Nelson B., Taskinen, Marja-Riitta, Ripatti, Samuli
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 26.05.2016 Public Library of Science (PLoS)
Subjects:	Adult Apolipoproteins B - genetics Biology and Life Sciences Cardiovascular disease Cholesterol Cholesterol, HDL - blood Cholesterol, HDL - genetics Coronary Artery Disease - blood Coronary Artery Disease - genetics Datasets Diabetes Dyslipidemias Dyslipidemias - blood Dyslipidemias - genetics Dyslipidemias - pathology Female Genetic aspects Genome-wide association studies Genome-Wide Association Study Genomes Grants Health aspects Humans Hyperlipidemia, Familial Combined - blood Hyperlipidemia, Familial Combined - genetics Hyperlipidemia, Familial Combined - pathology Hypotheses Lipids Lipoproteins, LDL - blood Lipoproteins, LDL - genetics Low density lipoprotein Male Medical research Medicine and Health Sciences Middle Aged Population Quantitative trait loci Ratios Research and Analysis Methods Studies Triglycerides Triglycerides - blood Triglycerides - genetics Values
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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