Suggestions from Geroscience for the Genetics of Age-Related Diseases
[...]the authors were able to validate risk loci buried in well studied datasets. The revolution in hygiene awareness, a major contributor to the unprecedented increase of life expectancy, and the concomitant emergence of an obesogenic environment (easy access to nutrient-rich food; reduced physical...
Saved in:
| Published in: | PLoS genetics Vol. 12; no. 11; p. e1006399 |
|---|---|
| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Public Library of Science
10.11.2016
Public Library of Science (PLoS) |
| Subjects: | |
| ISSN: | 1553-7404, 1553-7390, 1553-7404 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | [...]the authors were able to validate risk loci buried in well studied datasets. The revolution in hygiene awareness, a major contributor to the unprecedented increase of life expectancy, and the concomitant emergence of an obesogenic environment (easy access to nutrient-rich food; reduced physical activity) exemplify changes that promoted the epidemiological explosion of obesity, metabolic disorders, and eventually of major age-associated diseases. [...]subsequent generations were exposed to quite different environmental conditions and pressures during the last century, and it is easy to predict that the risk/protective effects of specific alleles changed accordingly. |
|---|---|
| AbstractList | [...]the authors were able to validate risk loci buried in well studied datasets. The revolution in hygiene awareness, a major contributor to the unprecedented increase of life expectancy, and the concomitant emergence of an obesogenic environment (easy access to nutrient-rich food; reduced physical activity) exemplify changes that promoted the epidemiological explosion of obesity, metabolic disorders, and eventually of major age-associated diseases. [...]subsequent generations were exposed to quite different environmental conditions and pressures during the last century, and it is easy to predict that the risk/protective effects of specific alleles changed accordingly. [...]the authors were able to validate risk loci buried in well studied datasets. The revolution in hygiene awareness, a major contributor to the unprecedented increase of life expectancy, and the concomitant emergence of an obesogenic environment (easy access to nutrient-rich food; reduced physical activity) exemplify changes that promoted the epidemiological explosion of obesity, metabolic disorders, and eventually of major age-associated diseases. [...]subsequent generations were exposed to quite different environmental conditions and pressures during the last century, and it is easy to predict that the risk/protective effects of specific alleles changed accordingly. |
| Audience | Academic |
| Author | Franceschi, Claudio Garagnani, Paolo |
| AuthorAffiliation | 4 CRBA ‐ Applied Biomedical Research Center, S. Orsola‐Malpighi Polyclinic, Bologna 1 IRCCS, Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy Stanford University School of Medicine, UNITED STATES 2 DIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy 3 C.I.G. Interdepartmental Center "L. Galvani", University of Bologna, Bologna, Italy |
| AuthorAffiliation_xml | – name: 2 DIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy – name: 1 IRCCS, Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy – name: 4 CRBA ‐ Applied Biomedical Research Center, S. Orsola‐Malpighi Polyclinic, Bologna – name: Stanford University School of Medicine, UNITED STATES – name: 3 C.I.G. Interdepartmental Center "L. Galvani", University of Bologna, Bologna, Italy |
| Author_xml | – sequence: 1 givenname: Claudio surname: Franceschi fullname: Franceschi, Claudio – sequence: 2 givenname: Paolo surname: Garagnani fullname: Garagnani, Paolo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27832069$$D View this record in MEDLINE/PubMed |
| BookMark | eNqVk1Fv0zAQxyM0xLbCN0AQCQnBQ4vtxHbCA1I1xqg0MWkDXq2Lc05dpXGJEwTfHmdtUTNNaMgPsS6__9--891pdNS4BqPoOSUzmkj6buX6toF6tqmwmVFCRJLnj6ITynkylSlJjw72x9Gp9ytCEp7l8kl0zGSWMCLyk-j8pq8q9J11jY9N69bxBbbOa4uNxti4Nu6WGGINdlb72Jl4XuH0GmvosIw_Wo_g0T-NHhuoPT7bfSfRt0_nX88-Ty-vLhZn88upljzvpoxBaUBLYMJgxoEBZqUwTCQcJJaclGWGFBg3LBBQsEQSzQFyFCRNQSeT6OXWd1M7r3YV8IpmaS54moYEJ9FiS5QOVmrT2jW0v5UDq24Drq0UtCGVGlUhy7IgBlmZmVQImtFEF4zkjBZaFDB4fdid1hdrLDU2XQv1yHT8p7FLVbmfilOSJlIEgzc7g9b96EOV1dp6jXUNDbp-uDfP0ywcnD8ATXJKBZM0oK_uoPcXYkdVEHK1jXHhinowVfNUZkwyTgav2T1UWCWurQ4NZ2yIjwRvR4LAdPirq6D3Xi1urv-D_fJw9ur7mH19wC4R6m7pXd3fNvEYfHH4gH9fbt_-AXi_BXToed-iUdp2MPiEMthaUaKGWdsXWA2zpnazFsTpHfHe_5-yP6pIK0w |
| CitedBy_id | crossref_primary_10_3389_fgene_2019_00433 crossref_primary_10_1016_j_smim_2018_09_003 crossref_primary_10_1016_j_maturitas_2021_01_007 crossref_primary_10_1016_j_smim_2018_10_008 crossref_primary_10_1016_j_arr_2018_06_003 crossref_primary_10_1161_CIRCRESAHA_118_312562 crossref_primary_10_1007_s10522_017_9695_7 crossref_primary_10_1111_1440_1681_13686 crossref_primary_10_1016_j_mad_2017_02_010 crossref_primary_10_3389_fmed_2018_00061 crossref_primary_10_1016_j_mad_2017_06_002 crossref_primary_10_1016_j_mad_2019_01_005 crossref_primary_10_1007_s11357_019_00125_8 crossref_primary_10_1186_s13148_020_00893_7 crossref_primary_10_3389_fimmu_2017_01960 |
| Cites_doi | 10.1111/acel.12338 10.1016/j.arr.2014.08.002 10.18632/aging.100562 10.1016/S0531-5565(00)00172-8 10.1155/2014/560340 10.1016/j.cell.2014.10.039 10.1086/302572 10.1038/srep32513 10.1371/journal.pgen.1005728 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2016 Public Library of Science 2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Franceschi C, Garagnani P (2016) Suggestions from Geroscience for the Genetics of Age-Related Diseases. PLoS Genet 12(11): e1006399. doi:10.1371/journal.pgen.1006399 2016 Franceschi, Garagnani 2016 Franceschi, Garagnani 2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Franceschi C, Garagnani P (2016) Suggestions from Geroscience for the Genetics of Age-Related Diseases. PLoS Genet 12(11): e1006399. doi:10.1371/journal.pgen.1006399 |
| Copyright_xml | – notice: COPYRIGHT 2016 Public Library of Science – notice: 2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Franceschi C, Garagnani P (2016) Suggestions from Geroscience for the Genetics of Age-Related Diseases. PLoS Genet 12(11): e1006399. doi:10.1371/journal.pgen.1006399 – notice: 2016 Franceschi, Garagnani 2016 Franceschi, Garagnani – notice: 2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Franceschi C, Garagnani P (2016) Suggestions from Geroscience for the Genetics of Age-Related Diseases. PLoS Genet 12(11): e1006399. doi:10.1371/journal.pgen.1006399 |
| DBID | AAYXX CITATION NPM IOV ISN ISR 3V. 7QP 7QR 7SS 7TK 7TM 7TO 7X7 7XB 88E 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pgen.1006399 |
| DatabaseName | CrossRef PubMed Gale In Context: Opposing Viewpoints Gale In Context: Canada Gale In Context: Science ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Entomology Abstracts (Full archive) Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC ProQuest SciTech Premium Collection Natural Science Collection Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Engineering Research Database ProQuest Health & Medical Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection ProQuest Health & Medical Collection Medical Database Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection AIDS and Cancer Research Abstracts Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1553-7404 |
| ExternalDocumentID | 1849654400 oai_doaj_org_article_b7ddb0fe2d8f4661813cb20921bc6ba0 PMC5104376 4280497141 A478272501 27832069 10_1371_journal_pgen_1006399 |
| Genre | Comment Journal Article |
| GeographicLocations | Italy |
| GeographicLocations_xml | – name: Italy |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7X7 88E 8FE 8FH 8FI 8FJ AAFWJ AAUCC AAWOE AAYXX ABDBF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AFFHD AFKRA AFPKN AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS B0M BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BHPHI BPHCQ BVXVI BWKFM CCPQU CITATION CS3 DIK DU5 E3Z EAP EAS EBD EBS EJD EMK EMOBN ESX F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IAO IGS IHR IHW INH INR IOV ISN ISR ITC KQ8 LK8 M1P M48 M7P O5R O5S OK1 OVT P2P PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PV9 QF4 QN7 RNS RPM RZL SV3 TR2 TUS UKHRP WOW XSB ~8M ALIPV C1A H13 IPNFZ NPM RIG WOQ 3V. 7QP 7QR 7SS 7TK 7TM 7TO 7XB 8FD 8FK AZQEC DWQXO FR3 GNUQQ H94 K9. P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM AAPBV ABPTK M~E |
| ID | FETCH-LOGICAL-c759t-22adfac7a26fe85a2ae8d6f2635a7ed50dd8e1a25f226fab2370c5aa9e6044ac3 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 20 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000392129600003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1553-7404 1553-7390 |
| IngestDate | Sun Aug 06 00:39:01 EDT 2023 Fri Oct 03 12:52:48 EDT 2025 Tue Nov 04 02:01:25 EST 2025 Sun Nov 09 10:21:24 EST 2025 Fri Sep 05 13:26:11 EDT 2025 Tue Oct 07 06:48:20 EDT 2025 Tue Nov 11 10:27:52 EST 2025 Tue Nov 04 17:42:38 EST 2025 Thu Nov 13 15:38:10 EST 2025 Thu Nov 13 15:53:58 EST 2025 Thu Nov 13 14:33:37 EST 2025 Thu May 22 21:15:38 EDT 2025 Thu Apr 03 07:08:37 EDT 2025 Tue Nov 18 21:19:19 EST 2025 Sat Nov 29 01:52:28 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c759t-22adfac7a26fe85a2ae8d6f2635a7ed50dd8e1a25f226fab2370c5aa9e6044ac3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Commentary-3 content type line 23 The authors have declared that no competing interests exist. |
| OpenAccessLink | https://www.proquest.com/docview/1849654400?pq-origsite=%requestingapplication% |
| PMID | 27832069 |
| PQID | 1849654400 |
| PQPubID | 1436339 |
| ParticipantIDs | plos_journals_1849654400 doaj_primary_oai_doaj_org_article_b7ddb0fe2d8f4661813cb20921bc6ba0 pubmedcentral_primary_oai_pubmedcentral_nih_gov_5104376 proquest_miscellaneous_1859481819 proquest_miscellaneous_1839116271 proquest_journals_1849654400 gale_infotracmisc_A478272501 gale_infotracacademiconefile_A478272501 gale_incontextgauss_ISR_A478272501 gale_incontextgauss_ISN_A478272501 gale_incontextgauss_IOV_A478272501 gale_healthsolutions_A478272501 pubmed_primary_27832069 crossref_citationtrail_10_1371_journal_pgen_1006399 crossref_primary_10_1371_journal_pgen_1006399 |
| PublicationCentury | 2000 |
| PublicationDate | 20161110 |
| PublicationDateYYYYMMDD | 2016-11-10 |
| PublicationDate_xml | – month: 11 year: 2016 text: 20161110 day: 10 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PLoS genetics |
| PublicationTitleAlternate | PLoS Genet |
| PublicationYear | 2016 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | P Garagnani (ref9) 2013; 5 C Franceschi (ref5) 2000; 35 D Corella (ref8) 2014; 18 K Fortney (ref10) 2015; 11 BK Kennedy (ref1) 2014; 159 P Garagnani (ref7) 2014; 2014 A Kulminski (ref3) M Sazzini (ref6) 2016; 6 AI Yashin (ref4) 1999; 65 VD Longo (ref2) 2015; 14 27832070 - PLoS Genet. 2016 Nov 10;12(11):e1006314 |
| References_xml | – volume: 14 start-page: 497 issue: 4 year: 2015 ident: ref2 article-title: Interventions to Slow Aging in Humans: Are We Ready? publication-title: Aging Cell doi: 10.1111/acel.12338 – ident: ref3 article-title: Pleiotropic Associations of Allelic Variants 1 in a 2q22 Region with Risks of Major Human Diseases and Mortality publication-title: PLoS Genet – volume: 18 start-page: 53 year: 2014 ident: ref8 article-title: Aging and cardiovascular diseases: the role of gene-diet interactions publication-title: Ageing Res Rev doi: 10.1016/j.arr.2014.08.002 – volume: 5 start-page: 373 issue: 5 year: 2013 ident: ref9 article-title: Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes publication-title: Aging (Albany NY) doi: 10.18632/aging.100562 – volume: 35 start-page: 879 issue: 6–7 year: 2000 ident: ref5 article-title: The network and the remodeling theories of aging: historical background and new perspectives publication-title: Exp Gerontol doi: 10.1016/S0531-5565(00)00172-8 – volume: 2014 start-page: 560340 year: 2014 ident: ref7 article-title: The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms publication-title: Biomed Res Int doi: 10.1155/2014/560340 – volume: 159 start-page: 709 issue: 4 year: 2014 ident: ref1 article-title: Geroscience: linking aging to chronic disease publication-title: Cell doi: 10.1016/j.cell.2014.10.039 – volume: 65 start-page: 1178 issue: 4 year: 1999 ident: ref4 article-title: Genes, demography, and life span: the contribution of demographic data in genetic studies on aging and longevity publication-title: Am J Hum Genet doi: 10.1086/302572 – volume: 6 start-page: 32513 year: 2016 ident: ref6 article-title: Complex interplay between neutral and adaptive evolution shaped differential genomic background and disease susceptibility along the Italian peninsula publication-title: Sci Rep doi: 10.1038/srep32513 – volume: 11 start-page: e1005728 issue: 12 year: 2015 ident: ref10 article-title: Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity publication-title: PLoS Genet doi: 10.1371/journal.pgen.1005728 – reference: 27832070 - PLoS Genet. 2016 Nov 10;12(11):e1006314 |
| SSID | ssj0035897 |
| Score | 2.3104856 |
| Snippet | [...]the authors were able to validate risk loci buried in well studied datasets. The revolution in hygiene awareness, a major contributor to the unprecedented... [...]the authors were able to validate risk loci buried in well studied datasets. The revolution in hygiene awareness, a major contributor to the... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e1006399 |
| SubjectTerms | Age Aging Aging (Biology) Biology and Life Sciences Body mass index Centenarians Datasets Demography Funding Gene expression Genetic aspects Genetics Genomes Health aspects Medicine and Health Sciences Mortality People and Places Research and Analysis Methods Studies |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQCiQuiHcDBQJC4hSaOPEjxwVa4LIgCqi3yHHG20pVsmp2kfrvO2NnowZVtAeumS-RMjP2zMjjbxh7i0tGWup5MkLapFAWklI5l0iuwXFuBBTWD5tQi4U-Oiq_Xxr1RT1hgR44KG6vVk1Tpw54o12BwURnua15WvKstrI2vlrHrGdbTIU9OBc6jFURIk8UlvXDpblcZXuDjd6v0EDUI0AhehKUPHf_uEPPVqddf1X6-XcX5aWwdHCf3RvyyXge_uMBuwXtQ3YnTJg8f8T2DzdLOkEi54rpKkn8Gbb8lRBjwhpjAhgT9zTRNcedi-dLSHyHHDTxp3B60z9mvw72f378kgyTExKrRLlOUMmNM1YZLh1oYbgB3UhHxDNGQSPSptGQGS7QHNKZmucqtcKYEmRaFMbmT9is7VrYYXHumqLMjMlkrQssf0qpgfsZxQAgnIlYvlVdZQdacZpucVr5szKF5UXQREUKrwaFRywZ31oFWo1r8B_IKiOWSLH9A3SVanCV6jpXidgrsmkVbpiOS7uaF5gmKcwFs4i98Qgixmip82ZpNn1fff32-wagw8VNQD8moHcDyHWoM2uGKxGoeWLlmiB3J0jcA-xEvENuulVdX2HdXkpR4AaNb25d92rx61FMH6WWuxa6DWFyDISSq-xfGM_2g1llxJ6G1TCaiEa48FSiRE3WycSGU0l7cuwJzjFOFBj4nv0Poz9ndzHHlYnv3Nxls_XZBl6w2_bP-qQ_e-l3jQsfSXEL priority: 102 providerName: Directory of Open Access Journals – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELeggLSX8c0KAwJC4ikjceKPPBZYAQmViQHaW-Q45zJpSqqlReK_5875gEwbjNf656r9ne07686_Y-wFbhlpqebJCGnDVFkIM-VcKLkGx7kRkFrfbEItFvroKDv4fVE8k8FPVPyq43RvhYRSTp9c6lV2jSdSUgnX_OBjf_ImQmeqex530cyR-_Eq_cNZPFmd1M15gebZesk_HND85v_-9Ftsuws1g1m7Nm6zK1DdYTfa5pM_77L9w82Skku07gJ6ZRK8g17aEgKMZQOMDQOSpSYl56B2wWwJoS-egzJ42yZ2mnvs63z_y5v3YddUIbRKZOsQ-S-dscpw6UALww3oUjrSpDEKShGVpYbYcIGWks4UPFGRFcZkIKM0NTa5zyZVXcEOCxJXpllsTCwLneLNKJMauG9fDADCmSlLeq5z2ymOU-OLk9yn0RTePFomciIo7wiasnCYtWoVN_6Bf01mHLCkl-0_QEvk3fbLC1WWReSAl9qlGJLoOLEFjzIeF1YWJpqyp7QI8vbx6bDr81mKEZTCMDGesuceQZoZFRXlLM2mafIPn75dAnS4uAzo8wj0sgO5GjmzpnstgcyTYNcIuTtC4vFgR8M7tK576pocr_SZFCme3TizX-vnDz8bhulLqRqvgnpDmAR9pOQq_hvGCwFhwDllD9rtM5iIurvwSOKIGm2skQ3HI9Xxd699ji4kRZ_48OJ_9YhtYVArQ1-qucsm69MNPGbX7Y_1cXP6xB8YvwBQemra priority: 102 providerName: Public Library of Science |
| Title | Suggestions from Geroscience for the Genetics of Age-Related Diseases |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27832069 https://www.proquest.com/docview/1849654400 https://www.proquest.com/docview/1839116271 https://www.proquest.com/docview/1859481819 https://pubmed.ncbi.nlm.nih.gov/PMC5104376 https://doaj.org/article/b7ddb0fe2d8f4661813cb20921bc6ba0 http://dx.doi.org/10.1371/journal.pgen.1006399 |
| Volume | 12 |
| WOSCitedRecordID | wos000392129600003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: Directory of Open Access Journals customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: DOA dateStart: 20050101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: M7P dateStart: 20050701 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: BENPR dateStart: 20050701 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Health & Medical Collection customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: 7X7 dateStart: 20050701 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: PIMPY dateStart: 20050701 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: FPL dateStart: 20050701 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fb9MwELZYBxIv_IYVRgkIiaewxInt5Al10MIkKNUGqDxFjmOXSVNSmhaJ_547xwkETWMSL3nofala3_nubJ-_I-Q5TBmusOZJMq78WCjtp8IYn9NEG0ol07GyzSbEbJYsFuncbbjVrqyy9YnWUReVwj3yA1iJpJzFYHKvVt997BqFp6uuhcYO2UWWhMiW7s1bTxyxpGmuwljkC1jcu6tzkQgPnKZerkBNWCmAgboXmiyDf-enB6uzqj4vCf27lvKP4DS9-b9_6xa54dJSb9zY0W1yRZd3yLWmUeXPu2Rysl3iQRTaqIc3Ury3uqXB1B7kvR7kkR5SWCPrs1cZb7zUvi2004X3pjkEqu-Rz9PJp9fvfNeAwVeCpRsfdFUYqYSk3OiESSp1UnCD_DVS6IIFRZHoUFIGWuVG5jQSgWJSppoHcSxVdJ8MyqrUe8SLTBGnoZQhz5MYVlEpTzS1rY611szIIYnasc-UYyfHJhlnmT1yE7BKaUYiQ41lTmND4ndvrRp2jn_gD1GtHRa5te0H1XqZuama5aIo8sBoWiQmhvQlCSOV0yClYa54LoMheYJGkTUXVTsPkY1jyLYEpJThkDyzCOTXKLGAZym3dZ0dffxyCdDJ7DKg4x7ohQOZCsZMSXezAkYeyb16yP0eElyJ6on30M7boauz39YJb7b2e774aSfGL8XKvVJXW8REEE85FeFFGEsaBMnpkDxoplOnIuwEQwMOEtGbaD0d9iXl6TfLkw7hJob4-fDin_6IXIckmPu2tHOfDDbrrX5Mrqofm9N6PSI7YiHsMxmR3cPJbH48svs28JzO34-swwHJ_OjD_Osvc42FgA |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Nb9QwELXKAoIL39BAoQGBegpNnNhODggttKWrlqWiBfUWHMdeKlXJstkF9U_xG5lxPiCoKr30wHX9EnntmfFzPH5DyHNwGa4w50kyrrxIKO0lwhiP01gbSiXTkbLFJsR4HB8eJntL5Gd7FwbTKtuYaAN1Xir8Rr4OO5GEswhM7vX0m4dVo_B0tS2hUZvFjj75AVu26tVoA-b3BaVbmwdvt72mqoCnBEvmHnQgN1IJSbnRMZNU6jjnBkVZpNA58_M81oGkDLrKjcxoKHzFpEw096NIqhDee4lcBhpBY5squNdG_pDFdTEXxkJPhInfXNULRbDeWMbLKZgFZiYgMegthbZiQLcuDKbHZXUa6f07d_OPxXDr5v82jLfIjYZ2u8PaT26TJV3cIVfrQpwnd8nm_mKCB23ogy7euHHf6VbmU7vA613gyS5KdKOqtVsadzjRnk0k1Lm7UR9yVffIpwv5D_fJoCgLvUzc0ORREkgZ8CyOYJeY8FhTW8pZa82MdEjYznWqGvV1LAJynNojRQG7sHokUrSQtLEQh3jdU9NafeQf-DdoRh0WtcPtD-VskjahKM1Enme-0TSPTQT0LA5ClVE_oUGmeCZ9h6yiEab1RdwuAqbDCNikAMocOOSZRaB-SIEJShO5qKp09OHzOUD74_OAPvZAaw3IlDBmSjY3R2DkUbysh1zpISFUql7zMvpVO3RV-tsb4MnWX05vfto140sxM7HQ5QIxIfAFTkVwFsaKIgH5dsiD2n27KcJKN9Tn0CJ6jt2bw35LcfTV6sDDchoBP3h4dtdXybXtg_e76e5ovPOIXAfCzz2bxrpCBvPZQj8mV9T3-VE1e2KDmUu-XLTb_wK8dd5G |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLZGuYgX7rDCYAGBeApNnNhOHhAqdIVqqFRsoL0Fx7HLpCkpTQvaX-PXcY5zgaBp7GUPvNZfItc-5_hzfPwdQp6Cy3CFOU-SceWGQmk3Fsa4nEbaUCqZDpUtNiGm0-jgIJ5tkJ_NXRhMq2xiog3UWaHwG_kAdiIxZyGY3MDUaRGz0fjV4puLFaTwpLUpp1GZyK4-_gHbt_LlZARz_YzS8c7-m3duXWHAVYLFKxc6kxmphKTc6IhJKnWUcYMCLVLojHlZFmlfUgbd5kamNBCeYlLGmnthKFUA771ALgoULbdpg7NmFQhYVBV2YSxwRRB79bW9QPiD2kpeLMBEMEsBSUJnWbTVA9o1orc4KsqTCPDfeZx_LIzj6__zkN4g12o67gwr_7lJNnR-i1yuCnQe3yY7e-s5HsChbzp4E8d5qxv5T-0A33eAPzso3Y1q105hnOFcuzbBUGfOqDr8Ku-QT-fyH-6SXl7kepM4gcnC2JfS52kUwu4x5pGmtsSz1poZ2SdBM--JqlXZsTjIUWKPGgXszqqRSNBaktpa-sRtn1pUqiT_wL9Gk2qxqClufyiW86QOUUkqsiz1jKZZZEKgbZEfqJR6MfVTxVPp9ck2GmRSXdBtI2MyDIFlCqDSfp88sQjUFcnRnOZyXZbJ5MPnM4D2pmcBfeyAntcgU8CYKVnfKIGRR1GzDnKrg4QQqjrNm-hjzdCVyW_PgCcb3zm5-XHbjC_FjMVcF2vEBMAjOBX-aRgrlgSkvE_uVa7cThFWwKEehxbRcfLOHHZb8sOvVh8eltkQeMP907u-Ta6AtyfvJ9PdB-Qq7AO4a7Nbt0hvtVzrh-SS-r46LJePbFxzyJfz9vpfvPznAw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Suggestions+from+Geroscience+for+the+Genetics+of+Age-Related+Diseases&rft.jtitle=PLoS+genetics&rft.au=Franceschi%2C+Claudio&rft.au=Garagnani%2C+Paolo&rft.date=2016-11-10&rft.pub=Public+Library+of+Science&rft.issn=1553-7390&rft.volume=12&rft.issue=11&rft_id=info:doi/10.1371%2Fjournal.pgen.1006399&rft.externalDBID=ISR&rft.externalDocID=A478272501 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1553-7404&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1553-7404&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1553-7404&client=summon |