Suggestions from Geroscience for the Genetics of Age-Related Diseases
[...]the authors were able to validate risk loci buried in well studied datasets. The revolution in hygiene awareness, a major contributor to the unprecedented increase of life expectancy, and the concomitant emergence of an obesogenic environment (easy access to nutrient-rich food; reduced physical...
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| Published in: | PLoS genetics Vol. 12; no. 11; p. e1006399 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Public Library of Science
10.11.2016
Public Library of Science (PLoS) |
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| ISSN: | 1553-7404, 1553-7390, 1553-7404 |
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| Abstract | [...]the authors were able to validate risk loci buried in well studied datasets. The revolution in hygiene awareness, a major contributor to the unprecedented increase of life expectancy, and the concomitant emergence of an obesogenic environment (easy access to nutrient-rich food; reduced physical activity) exemplify changes that promoted the epidemiological explosion of obesity, metabolic disorders, and eventually of major age-associated diseases. [...]subsequent generations were exposed to quite different environmental conditions and pressures during the last century, and it is easy to predict that the risk/protective effects of specific alleles changed accordingly. |
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| AbstractList | [...]the authors were able to validate risk loci buried in well studied datasets. The revolution in hygiene awareness, a major contributor to the unprecedented increase of life expectancy, and the concomitant emergence of an obesogenic environment (easy access to nutrient-rich food; reduced physical activity) exemplify changes that promoted the epidemiological explosion of obesity, metabolic disorders, and eventually of major age-associated diseases. [...]subsequent generations were exposed to quite different environmental conditions and pressures during the last century, and it is easy to predict that the risk/protective effects of specific alleles changed accordingly. [...]the authors were able to validate risk loci buried in well studied datasets. The revolution in hygiene awareness, a major contributor to the unprecedented increase of life expectancy, and the concomitant emergence of an obesogenic environment (easy access to nutrient-rich food; reduced physical activity) exemplify changes that promoted the epidemiological explosion of obesity, metabolic disorders, and eventually of major age-associated diseases. [...]subsequent generations were exposed to quite different environmental conditions and pressures during the last century, and it is easy to predict that the risk/protective effects of specific alleles changed accordingly. |
| Audience | Academic |
| Author | Franceschi, Claudio Garagnani, Paolo |
| AuthorAffiliation | 4 CRBA ‐ Applied Biomedical Research Center, S. Orsola‐Malpighi Polyclinic, Bologna 1 IRCCS, Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy Stanford University School of Medicine, UNITED STATES 2 DIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy 3 C.I.G. Interdepartmental Center "L. Galvani", University of Bologna, Bologna, Italy |
| AuthorAffiliation_xml | – name: 2 DIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy – name: 1 IRCCS, Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy – name: 4 CRBA ‐ Applied Biomedical Research Center, S. Orsola‐Malpighi Polyclinic, Bologna – name: Stanford University School of Medicine, UNITED STATES – name: 3 C.I.G. Interdepartmental Center "L. Galvani", University of Bologna, Bologna, Italy |
| Author_xml | – sequence: 1 givenname: Claudio surname: Franceschi fullname: Franceschi, Claudio – sequence: 2 givenname: Paolo surname: Garagnani fullname: Garagnani, Paolo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27832069$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3389_fgene_2019_00433 crossref_primary_10_1016_j_smim_2018_09_003 crossref_primary_10_1016_j_maturitas_2021_01_007 crossref_primary_10_1016_j_smim_2018_10_008 crossref_primary_10_1016_j_arr_2018_06_003 crossref_primary_10_1161_CIRCRESAHA_118_312562 crossref_primary_10_1007_s10522_017_9695_7 crossref_primary_10_1111_1440_1681_13686 crossref_primary_10_1016_j_mad_2017_02_010 crossref_primary_10_3389_fmed_2018_00061 crossref_primary_10_1016_j_mad_2017_06_002 crossref_primary_10_1016_j_mad_2019_01_005 crossref_primary_10_1007_s11357_019_00125_8 crossref_primary_10_1186_s13148_020_00893_7 crossref_primary_10_3389_fimmu_2017_01960 |
| Cites_doi | 10.1111/acel.12338 10.1016/j.arr.2014.08.002 10.18632/aging.100562 10.1016/S0531-5565(00)00172-8 10.1155/2014/560340 10.1016/j.cell.2014.10.039 10.1086/302572 10.1038/srep32513 10.1371/journal.pgen.1005728 |
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| Copyright | COPYRIGHT 2016 Public Library of Science 2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Franceschi C, Garagnani P (2016) Suggestions from Geroscience for the Genetics of Age-Related Diseases. PLoS Genet 12(11): e1006399. doi:10.1371/journal.pgen.1006399 2016 Franceschi, Garagnani 2016 Franceschi, Garagnani 2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Franceschi C, Garagnani P (2016) Suggestions from Geroscience for the Genetics of Age-Related Diseases. PLoS Genet 12(11): e1006399. doi:10.1371/journal.pgen.1006399 |
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| References | P Garagnani (ref9) 2013; 5 C Franceschi (ref5) 2000; 35 D Corella (ref8) 2014; 18 K Fortney (ref10) 2015; 11 BK Kennedy (ref1) 2014; 159 P Garagnani (ref7) 2014; 2014 A Kulminski (ref3) M Sazzini (ref6) 2016; 6 AI Yashin (ref4) 1999; 65 VD Longo (ref2) 2015; 14 27832070 - PLoS Genet. 2016 Nov 10;12(11):e1006314 |
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| Title | Suggestions from Geroscience for the Genetics of Age-Related Diseases |
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