Association between Air Pollutants and Asthma Emergency Room Visits and Hospital Admissions in Time Series Studies: A Systematic Review and Meta-Analysis

Air pollution constitutes a significant stimulus of asthma exacerbations; however, the impacts of exposure to major air pollutants on asthma-related hospital admissions and emergency room visits (ERVs) have not been fully determined. We sought to quantify the associations between short-term exposure...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	PloS one Ročník 10; číslo 9; s. e0138146
Hlavní autori:	Zheng, Xue-yan, Ding, Hong, Jiang, Li-na, Chen, Shao-wei, Zheng, Jin-ping, Qiu, Min, Zhou, Ying-xue, Chen, Qing, Guan, Wei-jie
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 18.09.2015 Public Library of Science (PLoS)
Predmet:	Aged Air Pollutants - analysis Air pollution Air Pollution - analysis Ambulatory Care - statistics & numerical data Analysis Asthma Asthma - epidemiology Asthma - therapy Carbon monoxide Care and treatment Child Children Confidence intervals Emergency medical care Emergency medical services Emergency Service, Hospital - statistics & numerical data Environmental aspects Environmental Exposure - analysis Environmental Exposure - statistics & numerical data Environmental risk Exposure Geriatrics Health care Health risks Hospital admission and discharge Hospitalization Humans Male Males Management Medical care utilization Medical ethics Meta-analysis Nitrogen dioxide Older people Outdoor air quality Ozone Particulate emissions Particulate matter Particulate Matter - analysis Patient Admission - statistics & numerical data Pollutants Risk assessment Risk factors Seasons Sensitivity Sensitivity analysis Subgroups Sulfur Sulfur compounds Sulfur dioxide Systematic review Time Factors Warm seasons Australia Europe China
ISSN:	1932-6203, 1932-6203
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	Air pollution constitutes a significant stimulus of asthma exacerbations; however, the impacts of exposure to major air pollutants on asthma-related hospital admissions and emergency room visits (ERVs) have not been fully determined. We sought to quantify the associations between short-term exposure to air pollutants [ozone (O3), carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), and particulate matter ≤10 μm (PM10) and PM2.5] and the asthma-related emergency room visits (ERV) and hospitalizations. Systematic computerized searches without language limitation were performed. Pooled relative risks (RRs) and 95% confidence intervals (95%CIs) were estimated using the random-effect models. Sensitivity analyses and subgroup analyses were also performed. After screening of 246 studies, 87 were included in our analyses. Air pollutants were associated with significantly increased risks of asthma ERVs and hospitalizations [O3: RR(95%CI), 1.009 (1.006, 1.011); I2 = 87.8%, population-attributable fraction (PAF) (95%CI): 0.8 (0.6, 1.1); CO: RR(95%CI), 1.045 (1.029, 1.061); I2 = 85.7%, PAF (95%CI): 4.3 (2.8, 5.7); NO2: RR(95%CI), 1.018 (1.014, 1.022); I2 = 87.6%, PAF (95%CI): 1.8 (1.4, 2.2); SO2: RR(95%CI), 1.011 (1.007, 1.015); I2 = 77.1%, PAF (95%CI): 1.1 (0.7, 1.5); PM10: RR(95%CI), 1.010 (1.008, 1.013); I2 = 69.1%, PAF (95%CI): 1.1 (0.8, 1.3); PM2.5: RR(95%CI), 1.023 (1.015, 1.031); I2 = 82.8%, PAF (95%CI): 2.3 (1.5, 3.1)]. Sensitivity analyses yielded compatible findings as compared with the overall analyses without publication bias. Stronger associations were found in hospitalized males, children and elderly patients in warm seasons with lag of 2 days or greater. Short-term exposures to air pollutants account for increased risks of asthma-related ERVs and hospitalizations that constitute a considerable healthcare utilization and socioeconomic burden.
Bibliografia:	ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 ObjectType-Undefined-4 Current Address: Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangdong, China Competing Interests: The authors have declared that no competing interests exist. Current Address: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China Conceived and designed the experiments: XYZ WJG JPZ QC. Performed the experiments: XYZ HD LNJ SWC. Analyzed the data: XYZ MQ YXZ. Wrote the paper: XYZ WJG. Provided critical review of the manuscript and approved the final submission: WJG QC.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0138146