Global Estimates of Prevalent and Incident Herpes Simplex Virus Type 2 Infections in 2012
Herpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult infection may present as painful genital ulcers. Neonatal infection has high morbidity and mortality. Additionally, HSV-2 likely contributes substantially to the spread of HIV infection. The globa...
Gespeichert in:
| Veröffentlicht in: | PloS one Jg. 10; H. 1; S. e114989 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
Public Library of Science
21.01.2015
Public Library of Science (PLoS) |
| Schlagworte: | |
| ISSN: | 1932-6203, 1932-6203 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Herpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult infection may present as painful genital ulcers. Neonatal infection has high morbidity and mortality. Additionally, HSV-2 likely contributes substantially to the spread of HIV infection. The global burden of HSV-2 infection was last estimated for 2003. Here we present new global estimates for 2012 of the burden of prevalent (existing) and incident (new) HSV-2 infection among females and males aged 15-49 years, using updated methodology to adjust for test performance and estimate by World Health Organization (WHO) region.
We conducted a literature review of HSV-2 prevalence studies world-wide since 2000. We then fitted a model with constant HSV-2 incidence by age to pooled HSV-2 prevalence values by age and sex. Prevalence values were adjusted for test sensitivity and specificity. The model estimated prevalence and incidence by sex for each WHO region to obtain global burden estimates. Uncertainty bounds were computed by refitting the model to reflect the variation in the underlying prevalence data. In 2012, we estimate that there were 417 million people aged 15-49 years (range: 274-678 million) living with HSV-2 infection world-wide (11.3% global prevalence), of whom 267 million were women. We also estimate that in 2012, 19.2 million (range: 13.0-28.6 million) individuals aged 15-49 years were newly-infected (0.5% of all individuals globally). The highest burden was in Africa. However, despite lower prevalence, South-East Asia and Western Pacific regions also contributed large numbers to the global totals because of large population sizes.
The global burden of HSV-2 infection is large, leaving over 400 million people at increased risk of genital ulcer disease, HIV acquisition, and transmission of HSV-2 to partners or neonates. These estimates highlight the critical need for development of vaccines, microbicides, and other new HSV prevention strategies. |
|---|---|
| AbstractList | Herpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult infection may present as painful genital ulcers. Neonatal infection has high morbidity and mortality. Additionally, HSV-2 likely contributes substantially to the spread of HIV infection. The global burden of HSV-2 infection was last estimated for 2003. Here we present new global estimates for 2012 of the burden of prevalent (existing) and incident (new) HSV-2 infection among females and males aged 15-49 years, using updated methodology to adjust for test performance and estimate by World Health Organization (WHO) region.
We conducted a literature review of HSV-2 prevalence studies world-wide since 2000. We then fitted a model with constant HSV-2 incidence by age to pooled HSV-2 prevalence values by age and sex. Prevalence values were adjusted for test sensitivity and specificity. The model estimated prevalence and incidence by sex for each WHO region to obtain global burden estimates. Uncertainty bounds were computed by refitting the model to reflect the variation in the underlying prevalence data. In 2012, we estimate that there were 417 million people aged 15-49 years (range: 274-678 million) living with HSV-2 infection world-wide (11.3% global prevalence), of whom 267 million were women. We also estimate that in 2012, 19.2 million (range: 13.0-28.6 million) individuals aged 15-49 years were newly-infected (0.5% of all individuals globally). The highest burden was in Africa. However, despite lower prevalence, South-East Asia and Western Pacific regions also contributed large numbers to the global totals because of large population sizes.
The global burden of HSV-2 infection is large, leaving over 400 million people at increased risk of genital ulcer disease, HIV acquisition, and transmission of HSV-2 to partners or neonates. These estimates highlight the critical need for development of vaccines, microbicides, and other new HSV prevention strategies. Background Herpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult infection may present as painful genital ulcers. Neonatal infection has high morbidity and mortality. Additionally, HSV-2 likely contributes substantially to the spread of HIV infection. The global burden of HSV-2 infection was last estimated for 2003. Here we present new global estimates for 2012 of the burden of prevalent (existing) and incident (new) HSV-2 infection among females and males aged 15–49 years, using updated methodology to adjust for test performance and estimate by World Health Organization (WHO) region. Methods and Findings We conducted a literature review of HSV-2 prevalence studies world-wide since 2000. We then fitted a model with constant HSV-2 incidence by age to pooled HSV-2 prevalence values by age and sex. Prevalence values were adjusted for test sensitivity and specificity. The model estimated prevalence and incidence by sex for each WHO region to obtain global burden estimates. Uncertainty bounds were computed by refitting the model to reflect the variation in the underlying prevalence data. In 2012, we estimate that there were 417 million people aged 15–49 years (range: 274–678 million) living with HSV-2 infection world-wide (11.3% global prevalence), of whom 267 million were women. We also estimate that in 2012, 19.2 million (range: 13.0–28.6 million) individuals aged 15–49 years were newly-infected (0.5% of all individuals globally). The highest burden was in Africa. However, despite lower prevalence, South-East Asia and Western Pacific regions also contributed large numbers to the global totals because of large population sizes. Conclusions The global burden of HSV-2 infection is large, leaving over 400 million people at increased risk of genital ulcer disease, HIV acquisition, and transmission of HSV-2 to partners or neonates. These estimates highlight the critical need for development of vaccines, microbicides, and other new HSV prevention strategies. Herpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult infection may present as painful genital ulcers. Neonatal infection has high morbidity and mortality. Additionally, HSV-2 likely contributes substantially to the spread of HIV infection. The global burden of HSV-2 infection was last estimated for 2003. Here we present new global estimates for 2012 of the burden of prevalent (existing) and incident (new) HSV-2 infection among females and males aged 15-49 years, using updated methodology to adjust for test performance and estimate by World Health Organization (WHO) region. We conducted a literature review of HSV-2 prevalence studies world-wide since 2000. We then fitted a model with constant HSV-2 incidence by age to pooled HSV-2 prevalence values by age and sex. Prevalence values were adjusted for test sensitivity and specificity. The model estimated prevalence and incidence by sex for each WHO region to obtain global burden estimates. Uncertainty bounds were computed by refitting the model to reflect the variation in the underlying prevalence data. In 2012, we estimate that there were 417 million people aged 15-49 years (range: 274-678 million) living with HSV-2 infection world-wide (11.3% global prevalence), of whom 267 million were women. We also estimate that in 2012, 19.2 million (range: 13.0-28.6 million) individuals aged 15-49 years were newly-infected (0.5% of all individuals globally). The highest burden was in Africa. However, despite lower prevalence, South-East Asia and Western Pacific regions also contributed large numbers to the global totals because of large population sizes. The global burden of HSV-2 infection is large, leaving over 400 million people at increased risk of genital ulcer disease, HIV acquisition, and transmission of HSV-2 to partners or neonates. These estimates highlight the critical need for development of vaccines, microbicides, and other new HSV prevention strategies. Background Herpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult infection may present as painful genital ulcers. Neonatal infection has high morbidity and mortality. Additionally, HSV-2 likely contributes substantially to the spread of HIV infection. The global burden of HSV-2 infection was last estimated for 2003. Here we present new global estimates for 2012 of the burden of prevalent (existing) and incident (new) HSV-2 infection among females and males aged 15-49 years, using updated methodology to adjust for test performance and estimate by World Health Organization (WHO) region. Methods and Findings We conducted a literature review of HSV-2 prevalence studies world-wide since 2000. We then fitted a model with constant HSV-2 incidence by age to pooled HSV-2 prevalence values by age and sex. Prevalence values were adjusted for test sensitivity and specificity. The model estimated prevalence and incidence by sex for each WHO region to obtain global burden estimates. Uncertainty bounds were computed by refitting the model to reflect the variation in the underlying prevalence data. In 2012, we estimate that there were 417 million people aged 15-49 years (range: 274-678 million) living with HSV-2 infection world-wide (11.3% global prevalence), of whom 267 million were women. We also estimate that in 2012, 19.2 million (range: 13.0-28.6 million) individuals aged 15-49 years were newly-infected (0.5% of all individuals globally). The highest burden was in Africa. However, despite lower prevalence, South-East Asia and Western Pacific regions also contributed large numbers to the global totals because of large population sizes. Conclusions The global burden of HSV-2 infection is large, leaving over 400 million people at increased risk of genital ulcer disease, HIV acquisition, and transmission of HSV-2 to partners or neonates. These estimates highlight the critical need for development of vaccines, microbicides, and other new HSV prevention strategies. BackgroundHerpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult infection may present as painful genital ulcers. Neonatal infection has high morbidity and mortality. Additionally, HSV-2 likely contributes substantially to the spread of HIV infection. The global burden of HSV-2 infection was last estimated for 2003. Here we present new global estimates for 2012 of the burden of prevalent (existing) and incident (new) HSV-2 infection among females and males aged 15-49 years, using updated methodology to adjust for test performance and estimate by World Health Organization (WHO) region.Methods and findingsWe conducted a literature review of HSV-2 prevalence studies world-wide since 2000. We then fitted a model with constant HSV-2 incidence by age to pooled HSV-2 prevalence values by age and sex. Prevalence values were adjusted for test sensitivity and specificity. The model estimated prevalence and incidence by sex for each WHO region to obtain global burden estimates. Uncertainty bounds were computed by refitting the model to reflect the variation in the underlying prevalence data. In 2012, we estimate that there were 417 million people aged 15-49 years (range: 274-678 million) living with HSV-2 infection world-wide (11.3% global prevalence), of whom 267 million were women. We also estimate that in 2012, 19.2 million (range: 13.0-28.6 million) individuals aged 15-49 years were newly-infected (0.5% of all individuals globally). The highest burden was in Africa. However, despite lower prevalence, South-East Asia and Western Pacific regions also contributed large numbers to the global totals because of large population sizes.ConclusionsThe global burden of HSV-2 infection is large, leaving over 400 million people at increased risk of genital ulcer disease, HIV acquisition, and transmission of HSV-2 to partners or neonates. These estimates highlight the critical need for development of vaccines, microbicides, and other new HSV prevention strategies. Herpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult infection may present as painful genital ulcers. Neonatal infection has high morbidity and mortality. Additionally, HSV-2 likely contributes substantially to the spread of HIV infection. The global burden of HSV-2 infection was last estimated for 2003. Here we present new global estimates for 2012 of the burden of prevalent (existing) and incident (new) HSV-2 infection among females and males aged 15-49 years, using updated methodology to adjust for test performance and estimate by World Health Organization (WHO) region.BACKGROUNDHerpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult infection may present as painful genital ulcers. Neonatal infection has high morbidity and mortality. Additionally, HSV-2 likely contributes substantially to the spread of HIV infection. The global burden of HSV-2 infection was last estimated for 2003. Here we present new global estimates for 2012 of the burden of prevalent (existing) and incident (new) HSV-2 infection among females and males aged 15-49 years, using updated methodology to adjust for test performance and estimate by World Health Organization (WHO) region.We conducted a literature review of HSV-2 prevalence studies world-wide since 2000. We then fitted a model with constant HSV-2 incidence by age to pooled HSV-2 prevalence values by age and sex. Prevalence values were adjusted for test sensitivity and specificity. The model estimated prevalence and incidence by sex for each WHO region to obtain global burden estimates. Uncertainty bounds were computed by refitting the model to reflect the variation in the underlying prevalence data. In 2012, we estimate that there were 417 million people aged 15-49 years (range: 274-678 million) living with HSV-2 infection world-wide (11.3% global prevalence), of whom 267 million were women. We also estimate that in 2012, 19.2 million (range: 13.0-28.6 million) individuals aged 15-49 years were newly-infected (0.5% of all individuals globally). The highest burden was in Africa. However, despite lower prevalence, South-East Asia and Western Pacific regions also contributed large numbers to the global totals because of large population sizes.METHODS AND FINDINGSWe conducted a literature review of HSV-2 prevalence studies world-wide since 2000. We then fitted a model with constant HSV-2 incidence by age to pooled HSV-2 prevalence values by age and sex. Prevalence values were adjusted for test sensitivity and specificity. The model estimated prevalence and incidence by sex for each WHO region to obtain global burden estimates. Uncertainty bounds were computed by refitting the model to reflect the variation in the underlying prevalence data. In 2012, we estimate that there were 417 million people aged 15-49 years (range: 274-678 million) living with HSV-2 infection world-wide (11.3% global prevalence), of whom 267 million were women. We also estimate that in 2012, 19.2 million (range: 13.0-28.6 million) individuals aged 15-49 years were newly-infected (0.5% of all individuals globally). The highest burden was in Africa. However, despite lower prevalence, South-East Asia and Western Pacific regions also contributed large numbers to the global totals because of large population sizes.The global burden of HSV-2 infection is large, leaving over 400 million people at increased risk of genital ulcer disease, HIV acquisition, and transmission of HSV-2 to partners or neonates. These estimates highlight the critical need for development of vaccines, microbicides, and other new HSV prevention strategies.CONCLUSIONSThe global burden of HSV-2 infection is large, leaving over 400 million people at increased risk of genital ulcer disease, HIV acquisition, and transmission of HSV-2 to partners or neonates. These estimates highlight the critical need for development of vaccines, microbicides, and other new HSV prevention strategies. |
| Audience | Academic |
| Author | Looker, Katharine J. Vickerman, Peter Magaret, Amalia S. Turner, Katherine M. E. Gottlieb, Sami L. Newman, Lori M. |
| AuthorAffiliation | Southern Illinois University School of Medicine, United States of America 2 Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America 1 School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom 3 Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland |
| AuthorAffiliation_xml | – name: Southern Illinois University School of Medicine, United States of America – name: 2 Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America – name: 1 School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom – name: 3 Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland |
| Author_xml | – sequence: 1 givenname: Katharine J. surname: Looker fullname: Looker, Katharine J. – sequence: 2 givenname: Amalia S. surname: Magaret fullname: Magaret, Amalia S. – sequence: 3 givenname: Katherine M. E. surname: Turner fullname: Turner, Katherine M. E. – sequence: 4 givenname: Peter surname: Vickerman fullname: Vickerman, Peter – sequence: 5 givenname: Sami L. surname: Gottlieb fullname: Gottlieb, Sami L. – sequence: 6 givenname: Lori M. surname: Newman fullname: Newman, Lori M. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25608026$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk11r2zAUhs3oWD-2fzA2w2BsF8n0YUvyLgaldG2g0LF2hV0JWT5OVBTLlezS_vspiTPiUsbwha2j57zyeXXOYbLXuAaS5C1GU0w5_nLret8oO21jeIowzgpRvEgOcEHJhBFE93a-95PDEG4Ryqlg7FWyT3KGBCLsIPl9Zl2pbHoaOrNUHYTU1ekPD_fKQtOlqqnSWaNNtVqcg28jcGWWrYWH9Mb4PqTXjy2kJEI16M64JqSmSQnC5HXyslY2wJvhfZT8-n56fXI-ubg8m50cX0w0z0U3qUqGcEUqqjDJeIaV5sAVygtcYK0ZcIIRZTXFNC95neWiJloXtSgrxDXThB4l7ze6rXVBDq4EiVkuMOKM00jMNkTl1K1sfSzUP0qnjFwHnJ9L5TujLciCsByUEFBnIgOBCkFBUZGVCBUcsI5a34bT-nIJlY6-eGVHouOdxizk3N3LjKJYURYFPg0C3t31EDq5NEGDtaoB16__m9CCUcoj-uEJ-nx1AzWPVyZNU7t4rl6JyuOMEFawDIlITZ-h4lPB0ujYQrWJ8VHC51FCZDp46OaqD0HOrn7-P3t5M2Y_7rALULZbBGf7de-MwXe7Tv-1eNu7Efi6AbR3IXiopTadWunE0oyVGMnVoGxNk6tBkcOgxOTsSfJW_59pfwC0WhQo |
| CitedBy_id | crossref_primary_10_1186_s12879_018_3288_1 crossref_primary_10_3389_fimmu_2022_861444 crossref_primary_10_1128_JVI_00908_17 crossref_primary_10_1136_bmjgh_2023_012717 crossref_primary_10_1371_journal_ppat_1008703 crossref_primary_10_1016_j_vaccine_2016_10_090 crossref_primary_10_1007_s40556_019_00232_8 crossref_primary_10_1016_j_antiviral_2020_104821 crossref_primary_10_1016_j_mcp_2022_101806 crossref_primary_10_1093_infdis_jiv317 crossref_primary_10_1136_sextrans_2024_056307 crossref_primary_10_1128_JVI_00616_18 crossref_primary_10_3389_fcimb_2019_00127 crossref_primary_10_1016_j_eimce_2020_04_011 crossref_primary_10_4103_ijpvm_ijpvm_239_22 crossref_primary_10_1016_j_intimp_2018_05_024 crossref_primary_10_1097_INF_0000000000001905 crossref_primary_10_1128_jvi_01638_24 crossref_primary_10_1016_j_cpcardiol_2023_101629 crossref_primary_10_1371_journal_pone_0140765 crossref_primary_10_1136_sextrans_2017_053244 crossref_primary_10_1128_mSphere_00058_21 crossref_primary_10_1016_j_vaccine_2017_03_074 crossref_primary_10_1080_14737159_2016_1251841 crossref_primary_10_1002_cpdd_1138 crossref_primary_10_1099_mgen_0_000586 crossref_primary_10_30699_jogcr_7_5_405 crossref_primary_10_3389_fimmu_2019_00500 crossref_primary_10_2147_JEP_S524226 crossref_primary_10_1371_journal_pmed_1003938 crossref_primary_10_1159_000464134 crossref_primary_10_1136_bmjopen_2023_083017 crossref_primary_10_1016_j_bcp_2022_115322 crossref_primary_10_1371_journal_pone_0177108 crossref_primary_10_1007_s40588_019_00131_6 crossref_primary_10_3389_fmicb_2021_825049 crossref_primary_10_1038_s41541_019_0129_1 crossref_primary_10_1016_j_heliyon_2025_e41836 crossref_primary_10_1186_s12879_019_3995_2 crossref_primary_10_1186_s12879_016_1954_8 crossref_primary_10_1007_s12325_019_00995_6 crossref_primary_10_4049_jimmunol_2300093 crossref_primary_10_1097_QAI_0000000000001136 crossref_primary_10_1016_j_vaccine_2016_02_078 crossref_primary_10_1177_2050313X19847029 crossref_primary_10_1186_s12879_015_1130_6 crossref_primary_10_1136_bmjgh_2024_015167 crossref_primary_10_1186_s12879_024_10421_0 crossref_primary_10_1002_rmv_2151 crossref_primary_10_1093_ofid_ofab218 crossref_primary_10_1177_09564624231213116 crossref_primary_10_1136_sextrans_2021_054972 crossref_primary_10_1016_j_microc_2024_112117 crossref_primary_10_1016_S1473_3099_17_30405_X crossref_primary_10_1128_JVI_01701_19 crossref_primary_10_3389_fpubh_2022_991040 crossref_primary_10_1016_j_vaccine_2019_05_009 crossref_primary_10_1097_OLQ_0000000000000547 crossref_primary_10_1128_JVI_01845_15 crossref_primary_10_1111_jam_13560 crossref_primary_10_1189_jlb_4RU0417_145RR crossref_primary_10_1007_s00508_019_01585_w crossref_primary_10_1080_23120053_2018_1531479 crossref_primary_10_1016_j_omtm_2020_05_011 crossref_primary_10_1016_j_vaccine_2017_09_044 crossref_primary_10_1016_j_coviro_2016_01_013 crossref_primary_10_1186_s12879_017_2527_1 crossref_primary_10_1136_sextrans_2018_053577 crossref_primary_10_3389_fmicb_2020_00508 crossref_primary_10_5812_ijcm_110452 crossref_primary_10_1097_OLQ_0000000000001121 crossref_primary_10_1128_JVI_00942_17 crossref_primary_10_1016_j_contraception_2015_09_002 crossref_primary_10_1371_journal_pmed_1002511 crossref_primary_10_1080_07391102_2019_1647286 crossref_primary_10_12688_gatesopenres_13261_1 crossref_primary_10_1002_ame2_12575 crossref_primary_10_1128_JVI_01574_18 crossref_primary_10_3389_fimmu_2023_1143870 crossref_primary_10_1093_infdis_jiv495 crossref_primary_10_1177_09564624251376077 crossref_primary_10_1056_NEJMoa1410649 crossref_primary_10_1371_journal_pone_0310250 crossref_primary_10_1093_molbev_msx113 crossref_primary_10_1093_cei_uxad012 crossref_primary_10_3390_ijms19020387 crossref_primary_10_1186_s12985_016_0501_y crossref_primary_10_1016_S1473_3099_17_30493_0 crossref_primary_10_1016_j_vaccine_2018_02_067 crossref_primary_10_1186_s12879_016_1707_8 crossref_primary_10_1186_s13027_021_00385_0 crossref_primary_10_1080_13880209_2017_1310907 crossref_primary_10_1093_molbev_msaa001 crossref_primary_10_1016_j_idc_2015_05_001 crossref_primary_10_1016_j_chom_2016_05_008 crossref_primary_10_3389_fimmu_2018_02932 crossref_primary_10_2217_fvl_15_82 crossref_primary_10_1371_journal_pone_0176687 crossref_primary_10_1371_journal_ppat_1006141 crossref_primary_10_1371_journal_pone_0131219 crossref_primary_10_2217_fvl_2018_0023 crossref_primary_10_1128_JVI_00227_19 crossref_primary_10_1007_s13205_020_02452_6 crossref_primary_10_1016_j_vaccine_2019_08_077 crossref_primary_10_1371_journal_ppat_1008795 crossref_primary_10_3389_fimmu_2016_00640 crossref_primary_10_3389_fmicb_2020_01862 crossref_primary_10_1016_j_ijpharm_2022_122239 crossref_primary_10_1186_s12884_016_0887_y crossref_primary_10_1371_journal_pcbi_1006129 crossref_primary_10_1016_j_vaccine_2015_12_076 crossref_primary_10_1093_infdis_jiz199 crossref_primary_10_23736_S1121_421X_20_02670_7 crossref_primary_10_1186_s12879_024_09180_9 crossref_primary_10_1371_journal_pone_0228252 crossref_primary_10_1002_jmv_29784 crossref_primary_10_1093_infdis_jiy415 crossref_primary_10_1016_j_bpobgyn_2016_05_008 crossref_primary_10_1093_infdis_jiae283 crossref_primary_10_1097_PGP_0000000000000964 crossref_primary_10_1016_j_vaccine_2016_12_018 crossref_primary_10_1038_s41435_018_0013_4 crossref_primary_10_1089_vim_2017_0033 crossref_primary_10_1002_SMMD_20220004 crossref_primary_10_1016_j_clinmicnews_2019_02_003 crossref_primary_10_1128_AAC_00956_16 crossref_primary_10_3389_fphar_2021_674682 crossref_primary_10_1055_a_1810_9142 crossref_primary_10_1128_JVI_01034_18 crossref_primary_10_1007_s00431_024_05581_9 crossref_primary_10_1016_j_anpedi_2018_01_004 crossref_primary_10_1038_s41541_020_0184_7 crossref_primary_10_2147_IDR_S396990 crossref_primary_10_4103_joco_joco_85_24 crossref_primary_10_1016_j_ijid_2020_04_025 crossref_primary_10_3389_fcimb_2021_649722 crossref_primary_10_1186_s12916_019_1285_x crossref_primary_10_1371_journal_ppat_1005950 crossref_primary_10_3389_fimmu_2025_1586271 crossref_primary_10_1016_j_anpede_2018_01_008 crossref_primary_10_1016_j_clp_2019_02_009 crossref_primary_10_1038_s41598_021_94289_z crossref_primary_10_1136_bmjopen_2016_012571 crossref_primary_10_4103_ijmr_IJMR_1239_18 crossref_primary_10_1186_s13063_022_06663_5 crossref_primary_10_1371_journal_ppat_1012477 crossref_primary_10_1016_j_virol_2017_06_031 crossref_primary_10_1099_jgv_0_000895 crossref_primary_10_1016_j_jcv_2016_08_212 crossref_primary_10_1016_j_ijbiomac_2022_04_120 crossref_primary_10_1016_j_survophthal_2017_11_001 crossref_primary_10_1128_mSphereDirect_00283_18 crossref_primary_10_4103_IJO_IJO_2963_24 crossref_primary_10_1097_INF_0000000000002846 crossref_primary_10_1155_2018_3750646 crossref_primary_10_1371_journal_ppat_1010969 crossref_primary_10_1016_j_lana_2023_100427 crossref_primary_10_1126_sciimmunol_aax2454 crossref_primary_10_1136_sextrans_2019_054400 crossref_primary_10_1039_D2RA06749H crossref_primary_10_1371_journal_pone_0145228 crossref_primary_10_1097_OLQ_0000000000001342 crossref_primary_10_3389_fphar_2021_707695 crossref_primary_10_1016_j_jcv_2017_11_004 crossref_primary_10_1128_CMR_00043_15 crossref_primary_10_1128_JVI_00958_17 crossref_primary_10_1186_s40348_020_00106_4 crossref_primary_10_1097_QAI_0000000000002743 crossref_primary_10_1128_JVI_01234_17 crossref_primary_10_1016_j_vaccine_2017_10_084 crossref_primary_10_1371_journal_pone_0215553 crossref_primary_10_29252_ijrm_14_10_615 crossref_primary_10_1093_infdis_jiw043 crossref_primary_10_1590_0074_02760180328 crossref_primary_10_1016_S1473_3099_17_30398_5 crossref_primary_10_1016_j_eplepsyres_2016_07_008 crossref_primary_10_1371_journal_pone_0170773 crossref_primary_10_1071_SH23134 crossref_primary_10_1128_mSphere_00106_17 crossref_primary_10_1038_s41541_020_00254_8 crossref_primary_10_1002_jia2_25361 crossref_primary_10_1097_OLQ_0000000000000702 crossref_primary_10_1128_cmr_00021_24 crossref_primary_10_1371_journal_pone_0214151 crossref_primary_10_1016_j_antiviral_2017_03_028 crossref_primary_10_7448_IAS_20_1_21521 crossref_primary_10_1093_infdis_jiz203 crossref_primary_10_1097_QCO_0000000000000343 crossref_primary_10_2471_BLT_19_237149 crossref_primary_10_1097_GRF_0000000000000627 crossref_primary_10_1097_OLQ_0000000000000791 crossref_primary_10_12688_f1000research_53541_1 crossref_primary_10_1371_journal_pone_0197845 crossref_primary_10_12688_f1000research_53541_2 crossref_primary_10_4103_jgid_jgid_56_18 crossref_primary_10_4102_phcfm_v13i1_3091 crossref_primary_10_1016_j_cyto_2018_06_028 crossref_primary_10_1134_S0026893321020242 crossref_primary_10_1371_journal_pmed_1002475 crossref_primary_10_1371_journal_ppat_1007095 crossref_primary_10_1038_s41385_019_0203_z crossref_primary_10_7774_cevr_2024_13_1_21 crossref_primary_10_1016_j_chom_2021_02_004 crossref_primary_10_1186_s12889_020_09699_x crossref_primary_10_3389_fmicb_2018_02406 crossref_primary_10_1016_j_neuro_2025_03_007 crossref_primary_10_1111_and_14163 crossref_primary_10_1089_ast_2021_0009 crossref_primary_10_1371_journal_pone_0253005 crossref_primary_10_1016_j_ijpharm_2024_123988 crossref_primary_10_1080_14737159_2016_1243473 crossref_primary_10_1093_infdis_jiac284 crossref_primary_10_1128_JVI_01206_20 crossref_primary_10_1038_s42003_022_04067_4 crossref_primary_10_3389_fimmu_2020_613799 crossref_primary_10_1038_s41467_019_12732_2 crossref_primary_10_1097_OLQ_0000000000000689 crossref_primary_10_1371_journal_pone_0209379 crossref_primary_10_1093_infdis_jiy372 crossref_primary_10_1111_aji_12689 crossref_primary_10_1007_s40588_018_0082_1 crossref_primary_10_1093_molbev_msac142 crossref_primary_10_1007_s12250_016_3917_z crossref_primary_10_1007_s10096_023_04688_5 crossref_primary_10_1093_infdis_jiz225 crossref_primary_10_1016_j_jcv_2017_12_006 crossref_primary_10_1016_j_meegid_2018_03_004 crossref_primary_10_1089_aid_2022_0070 crossref_primary_10_1016_j_jep_2017_08_010 crossref_primary_10_1186_s12879_020_4931_1 crossref_primary_10_1038_s41433_020_01153_x crossref_primary_10_1097_QAD_0000000000002323 crossref_primary_10_1002_cbdv_202200411 crossref_primary_10_3389_fpubh_2019_00004 crossref_primary_10_1097_OLQ_0000000000000336 crossref_primary_10_1111_jnc_14304 crossref_primary_10_1002_mma_7628 crossref_primary_10_1371_journal_pone_0178907 crossref_primary_10_1093_biolre_ioaa087 crossref_primary_10_1128_JVI_01824_18 crossref_primary_10_1016_j_cnur_2020_06_007 crossref_primary_10_1016_j_ijbiomac_2020_06_134 crossref_primary_10_5501_wjv_v12_i3_172 crossref_primary_10_1016_j_vaccine_2016_03_111 crossref_primary_10_3389_fimmu_2024_1369086 crossref_primary_10_1136_sextrans_2016_052838 crossref_primary_10_1038_s41598_022_05188_w crossref_primary_10_1007_s00439_016_1686_2 crossref_primary_10_1128_JVI_02257_16 |
| Cites_doi | 10.1136/sti.77.4.232 10.1136/sextrans-2013-051453 10.1016/j.epidem.2010.08.003 10.1056/NEJM199708213370801 10.1097/00007435-200304000-00007 10.1056/NEJMoa0904849 10.1177/0956462412472816 10.1016/j.jri.2010.12.004 10.2471/BLT.07.046128 10.1086/338231 10.1086/510537 10.1001/jama.289.2.203 10.1055/s-0032-1332802 10.1056/NEJMoa1103151 10.1086/342104 10.1086/314486 10.1097/00002030-200108004-00006 10.1097/01.OLQ.0000092387.58746.C7 10.4159/harvard.9780674428928 10.1016/S0140-6736(09)62038-9 10.1371/journal.pone.0059037 10.1097/01.aids.0000198081.09337.a7 10.1086/343739 10.1001/jama.296.8.964 10.1111/j.1469-0691.2004.00836.x 10.1097/QAD.0b013e3282004929 10.1136/sti.2008.033902 10.1016/S0140-6736(08)60920-4 10.1128/JCM.37.5.1632-1633.1999 10.1016/j.vaccine.2014.01.053 10.1016/S0140-6736(07)61908-4 10.1016/S0140-6736(00)04331-2 10.1056/NEJMoa035144 10.1016/j.vaccine.2013.08.066 10.1056/NEJMoa0800260 10.1128/JCM.01336-09 10.1086/368357 10.7326/0003-4819-121-11-199412010-00004 10.7326/0003-4819-123-11-199512010-00006 10.1111/j.1469-0691.2006.01370.x 10.1056/NEJM199710163371601 10.1016/S0140-6736(13)62035-8 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2015 Public Library of Science 2015 Looker et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2015 Looker et al 2015 Looker et al |
| Copyright_xml | – notice: COPYRIGHT 2015 Public Library of Science – notice: 2015 Looker et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2015 Looker et al 2015 Looker et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0114989 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database (ProQuest) Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database (Proquest) Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials - QC Biological Science Collection ProQuest Central ProQuest Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database (ProQuest) Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection Proquest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Agricultural Science Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Medicine |
| DocumentTitleAlternate | Global Estimates of Herpes Simplex Virus Type 2 Infections (2012) |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1658107673 oai_doaj_org_article_9265ea88ef484e80983ea384b0097e1c PMC4301914 3604059881 A422696408 25608026 10_1371_journal_pone_0114989 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIAID NIH HHS grantid: P01 AI030731 – fundername: PHS HHS grantid: P01-A1-030731-23 – fundername: World Health Organization grantid: 001 |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV CGR CUY CVF ECM EIF IPNFZ NPM RIG BBORY 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 5PM - 02 AAPBV ABPTK ADACO BBAFP KM |
| ID | FETCH-LOGICAL-c758t-db601d2d3a124741ac7e7a059191cc6e721036f3135b7f458f2cc9f8bd07c6c23 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 634 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000348205300007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1932-6203 |
| IngestDate | Fri Nov 26 17:12:52 EST 2021 Tue Oct 14 19:07:41 EDT 2025 Tue Nov 04 02:01:39 EST 2025 Sun Nov 09 09:51:27 EST 2025 Tue Oct 07 07:29:24 EDT 2025 Sat Nov 29 13:01:01 EST 2025 Sat Nov 29 10:05:53 EST 2025 Wed Nov 26 10:28:06 EST 2025 Wed Nov 26 09:47:44 EST 2025 Thu May 22 20:54:49 EDT 2025 Mon Jul 21 05:49:18 EDT 2025 Sat Nov 29 06:27:30 EST 2025 Tue Nov 18 21:10:25 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c758t-db601d2d3a124741ac7e7a059191cc6e721036f3135b7f458f2cc9f8bd07c6c23 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: KJL LMN. Performed the experiments: KJL. Analyzed the data: KJL ASM KMET PV SLG LMN. Contributed reagents/materials/analysis tools: KJL ASM KMET PV. Wrote the paper: KJL ASM KMET PV SLG LMN. Contributed to the ongoing progress and direction of the research: KJL ASM KMET PV SLG LMN. Provided technical expertise and input: KJL ASM KMET PV SLG LMN. |
| OpenAccessLink | https://doaj.org/article/9265ea88ef484e80983ea384b0097e1c |
| PMID | 25608026 |
| PQID | 1658107673 |
| PQPubID | 1436336 |
| ParticipantIDs | plos_journals_1658107673 doaj_primary_oai_doaj_org_article_9265ea88ef484e80983ea384b0097e1c pubmedcentral_primary_oai_pubmedcentral_nih_gov_4301914 proquest_miscellaneous_1652396337 proquest_journals_1658107673 gale_infotracmisc_A422696408 gale_infotracacademiconefile_A422696408 gale_incontextgauss_ISR_A422696408 gale_incontextgauss_IOV_A422696408 gale_healthsolutions_A422696408 pubmed_primary_25608026 crossref_citationtrail_10_1371_journal_pone_0114989 crossref_primary_10_1371_journal_pone_0114989 |
| PublicationCentury | 2000 |
| PublicationDate | 2015-01-21 |
| PublicationDateYYYYMMDD | 2015-01-21 |
| PublicationDate_xml | – month: 01 year: 2015 text: 2015-01-21 day: 21 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2015 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | (ref2) 2010; 59 C Kaushic (ref34) 2011; 88 R Gupta (ref1) 2007; 370 EE Freeman (ref5) 2006; 20 CH Mercer (ref47) 2013; 382 A Wald (ref13) 2002; 185 ref19 RH Gray (ref9) 2001; 357 ZA Brown (ref50) 2003; 289 C Celum (ref17) 2010; 362 JM Brown (ref6) 2007; 21 D Watson-Jones (ref16) 2008; 358 M Augenbraun (ref12) 1995; 123 ref44 C Kenyon (ref14) 2013; 24 J Benedetti (ref49) 1994; 121 JS Smith (ref24) 2002; 186 KK Tassiopoulos (ref41) 2007; 195 RL Ashley (ref27) 2001; 77 ref31 SJ Reynolds (ref7) 2003; 187 ref32 SG Pinninti (ref4) 2013; 30 C Johnston (ref21) 2014; 32 JR Lingappa (ref10) 2010; 375 A Wald (ref48) 2002; 35 CM Roberts (ref43) 2003; 30 C Celum (ref15) 2008; 371 J Todd (ref8) 2013; 8 R Ashley-Morrow (ref40) 2003; 30 R Ashley-Morrow (ref30) 2004; 10 T Schacker (ref11) 1998; 178 RL Ashley (ref39) 1999; 37 ref23 ref26 N Ryder (ref46) 2009; 85 ref20 N Broutet (ref22) 2014; 32 L Corey (ref33) 2004; 350 E Gray (ref45) 2008; 121 ref28 LJ Abu-Raddad (ref38) 2010; 2 ref29 RB Belshe (ref18) 2012; 366 F Xu (ref37) 2006; 296 ZA Brown (ref3) 1997; 337 JR Glynn (ref35) 2001; 15 R Morrow (ref25) 2006; 12 DT Fleming (ref36) 1997; 337 KC Pena (ref42) 2010; 48 25992922 - PLoS One. 2015 May 20;10(5):e0128615. doi: 10.1371/journal.pone.0128615. |
| References_xml | – volume: 77 start-page: 232 year: 2001 ident: ref27 article-title: Sorting out the new HSV type specific antibody tests publication-title: Sex Transm Infect doi: 10.1136/sti.77.4.232 – ident: ref44 doi: 10.1136/sextrans-2013-051453 – ident: ref20 – volume: 2 start-page: 173 year: 2010 ident: ref38 article-title: HSV-2 serology can be predictive of HIV epidemic potential and hidden sexual risk behavior in the Middle East and North Africa publication-title: Epidemics doi: 10.1016/j.epidem.2010.08.003 – volume: 337 start-page: 509 year: 1997 ident: ref3 article-title: The acquisition of herpes simplex virus during pregnancy publication-title: N Engl J Med doi: 10.1056/NEJM199708213370801 – volume: 121 start-page: 43 year: 2008 ident: ref45 article-title: Herpes simplex type 1 versus Herpes simplex type 2 in anogenital herpes; a 10 year study from the Waikato region of New Zealand publication-title: N Z Med J – volume: 30 start-page: 310 year: 2003 ident: ref40 article-title: Time course of seroconversion by HerpeSelect ELISA after acquisition of genital herpes simplex virus type 1 (HSV-1) or HSV-2 publication-title: Sex Transm Dis doi: 10.1097/00007435-200304000-00007 – volume: 362 start-page: 427 year: 2010 ident: ref17 article-title: Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2 publication-title: N Engl J Med doi: 10.1056/NEJMoa0904849 – volume: 24 start-page: 375 year: 2013 ident: ref14 article-title: Determinants of generalized herpes simplex virus-2 epidemics: the role of sexual partner concurrency publication-title: Int J STD AIDS doi: 10.1177/0956462412472816 – volume: 59 start-page: 456 year: 2010 ident: ref2 article-title: Seroprevalence of herpes simplex virus type 2 among persons aged 14–49 years–United States, 2005–2008 publication-title: MMWR Morb Mortal Wkly Rep – volume: 88 start-page: 204 year: 2011 ident: ref34 article-title: Increased prevalence of sexually transmitted viral infections in women: the role of female sex hormones in regulating susceptibility and immune responses publication-title: J Reprod Immunol doi: 10.1016/j.jri.2010.12.004 – ident: ref23 doi: 10.2471/BLT.07.046128 – volume: 185 start-page: 45 year: 2002 ident: ref13 article-title: Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis publication-title: J Infect Dis doi: 10.1086/338231 – ident: ref26 – volume: 195 start-page: 493 year: 2007 ident: ref41 article-title: Predictors of herpes simplex virus type 2 prevalence and incidence among bar and hotel workers in Moshi, Tanzania publication-title: J Infect Dis doi: 10.1086/510537 – volume: 289 start-page: 203 year: 2003 ident: ref50 article-title: Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant publication-title: JAMA doi: 10.1001/jama.289.2.203 – volume: 30 start-page: 113 year: 2013 ident: ref4 article-title: Maternal and neonatal herpes simplex virus infections publication-title: Am J Perinatol doi: 10.1055/s-0032-1332802 – volume: 366 start-page: 34 year: 2012 ident: ref18 article-title: Efficacy results of a trial of a herpes simplex vaccine publication-title: N Engl J Med doi: 10.1056/NEJMoa1103151 – volume: 35 start-page: S173 year: 2002 ident: ref48 article-title: Serological testing for herpes simplex virus (HSV)-1 and HSV-2 infection publication-title: Clin Infect Dis doi: 10.1086/342104 – volume: 178 start-page: 1616 year: 1998 ident: ref11 article-title: Frequency of symptomatic and asymptomatic herpes simplex virus type 2 reactivations among human immunodeficiency virus-infected men publication-title: J Infect Dis doi: 10.1086/314486 – volume: 15 start-page: S51 year: 2001 ident: ref35 article-title: Why do young women have a much higher prevalence of HIV than young men? A study in Kisumu, Kenya and Ndola, Zambia publication-title: AIDS doi: 10.1097/00002030-200108004-00006 – volume: 30 start-page: 797 year: 2003 ident: ref43 article-title: Increasing proportion of herpes simplex virus type 1 as a cause of genital herpes infection in college students publication-title: Sex Transm Dis doi: 10.1097/01.OLQ.0000092387.58746.C7 – ident: ref28 doi: 10.4159/harvard.9780674428928 – volume: 375 start-page: 824 year: 2010 ident: ref10 article-title: Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(09)62038-9 – volume: 8 start-page: e59037 year: 2013 ident: ref8 article-title: Effect of genital herpes on cervicovaginal HIV shedding in women co-infected with HIV AND HSV-2 in Tanzania publication-title: PLoS One doi: 10.1371/journal.pone.0059037 – ident: ref29 – volume: 20 start-page: 73 year: 2006 ident: ref5 article-title: Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies publication-title: AIDS doi: 10.1097/01.aids.0000198081.09337.a7 – volume: 186 start-page: S3 year: 2002 ident: ref24 article-title: Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review publication-title: J Infect Dis doi: 10.1086/343739 – volume: 296 start-page: 964 year: 2006 ident: ref37 article-title: Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States publication-title: JAMA doi: 10.1001/jama.296.8.964 – volume: 10 start-page: 530 year: 2004 ident: ref30 article-title: Performance of focus ELISA tests for herpes simplex virus type 1 (HSV-1) and HSV-2 antibodies among women in ten diverse geographical locations publication-title: Clin Microbiol Infect doi: 10.1111/j.1469-0691.2004.00836.x – volume: 21 start-page: 1515 year: 2007 ident: ref6 article-title: Incident and prevalent herpes simplex virus type 2 infection increases risk of HIV acquisition among women in Uganda and Zimbabwe publication-title: AIDS doi: 10.1097/QAD.0b013e3282004929 – volume: 85 start-page: 416 year: 2009 ident: ref46 article-title: Increasing role of herpes simplex virus type 1 in first-episode anogenital herpes in heterosexual women and younger men who have sex with men, 1992–2006 publication-title: Sex Transm Infect doi: 10.1136/sti.2008.033902 – ident: ref19 – ident: ref32 – volume: 371 start-page: 2109 year: 2008 ident: ref15 article-title: Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(08)60920-4 – volume: 37 start-page: 1632 year: 1999 ident: ref39 article-title: Ability of a rapid serology test to detect seroconversion to herpes simplex virus type 2 glycoprotein G soon after infection publication-title: J Clin Microbiol doi: 10.1128/JCM.37.5.1632-1633.1999 – volume: 32 start-page: 1630 year: 2014 ident: ref22 article-title: Vaccines against sexually transmitted infections: the way forward publication-title: Vaccine doi: 10.1016/j.vaccine.2014.01.053 – volume: 370 start-page: 2127 year: 2007 ident: ref1 article-title: Genital herpes publication-title: Lancet doi: 10.1016/S0140-6736(07)61908-4 – volume: 357 start-page: 1149 year: 2001 ident: ref9 article-title: Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda publication-title: Lancet doi: 10.1016/S0140-6736(00)04331-2 – volume: 350 start-page: 11 year: 2004 ident: ref33 article-title: Once-daily valacyclovir to reduce the risk of transmission of genital herpes publication-title: N Engl J Med doi: 10.1056/NEJMoa035144 – volume: 32 start-page: 1553 year: 2014 ident: ref21 article-title: Current status and prospects for development of an HSV vaccine publication-title: Vaccine doi: 10.1016/j.vaccine.2013.08.066 – volume: 358 start-page: 1560 year: 2008 ident: ref16 article-title: Effect of herpes simplex suppression on incidence of HIV among women in Tanzania publication-title: N Engl J Med doi: 10.1056/NEJMoa0800260 – volume: 48 start-page: 150 year: 2010 ident: ref42 article-title: Genital herpes simplex virus type 1 in women: detection in cervicovaginal specimens from gynecological practices in the United States publication-title: J Clin Microbiol doi: 10.1128/JCM.01336-09 – volume: 187 start-page: 1513 year: 2003 ident: ref7 article-title: Recent herpes simplex virus type 2 infection and the risk of human immunodeficiency virus type 1 acquisition in India publication-title: J Infect Dis doi: 10.1086/368357 – volume: 121 start-page: 847 year: 1994 ident: ref49 article-title: Recurrence rates in genital herpes after symptomatic first-episode infection publication-title: Ann Intern Med doi: 10.7326/0003-4819-121-11-199412010-00004 – volume: 123 start-page: 845 year: 1995 ident: ref12 article-title: Increased genital shedding of herpes simplex virus type 2 in HIV-seropositive women publication-title: Ann Intern Med doi: 10.7326/0003-4819-123-11-199512010-00006 – volume: 12 start-page: 463 year: 2006 ident: ref25 article-title: Performance of a novel test for IgM and IgG antibodies in subjects with culture-documented genital herpes simplex virus-1 or -2 infection publication-title: Clin Microbiol Infect doi: 10.1111/j.1469-0691.2006.01370.x – volume: 337 start-page: 1105 year: 1997 ident: ref36 article-title: Herpes simplex virus type 2 in the United States, 1976 to 1994 publication-title: N Engl J Med doi: 10.1056/NEJM199710163371601 – ident: ref31 – volume: 382 start-page: 1781 year: 2013 ident: ref47 article-title: Changes in sexual attitudes and lifestyles in Britain through the life course and over time: findings from the National Surveys of Sexual Attitudes and Lifestyles (Natsal) publication-title: Lancet doi: 10.1016/S0140-6736(13)62035-8 – reference: 25992922 - PLoS One. 2015 May 20;10(5):e0128615. doi: 10.1371/journal.pone.0128615. |
| SSID | ssj0053866 |
| Score | 2.638508 |
| Snippet | Herpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult infection may present as painful genital ulcers.... Background Herpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult infection may present as painful genital... BackgroundHerpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult infection may present as painful genital... Background Herpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult infection may present as painful genital... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e114989 |
| SubjectTerms | Adjustment Adolescent Adult Analysis Biology and Life Sciences Clinical trials Disease transmission Epidemics Epidemiology Estimates Female Females Health aspects Health risk assessment Health risks Herpes Genitalis - drug therapy Herpes Genitalis - epidemiology Herpes Genitalis - prevention & control Herpes simplex Herpes viruses Herpesvirus 2, Human Herpesvirus Vaccines - therapeutic use HIV HIV infections Human immunodeficiency virus Humans Incidence Infection Infections Literature reviews Male Males Medical research Medicine Medicine and Health Sciences Mens health Microbicides Middle Aged Models, Theoretical Morbidity Mortality Neonates Pediatric diseases Physical Sciences Prevalence Refitting Reproductive health Research and Analysis Methods Sex Sexually transmitted diseases STD Studies Survival analysis Ulcers Uncertainty Vaccines Viruses Womens health Young adults |
| SummonAdditionalLinks | – databaseName: Nursing & Allied Health Database (ProQuest) dbid: 7RV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Nb5VAEN_o0xgv1daPolVXY6IeaIHlscvJVNOmHqym1Zd6Ist-VJIWEN4z_vnOwILFNGrilf1BYGd25jfs7Awhz4EhWCFybJoRWT820vrAMpQPzFbFc2GAcYuu2QQ_PBQnJ-lH98OtdWmVg03sDLWuFP4j3wnBVUKoknD2uv7mY9co3F11LTSukmshcmPQZ360GCwxrOUkccflGA93nHS266o02xgIpNjc_YI76qr2j7Z5Vp9V7WXE8_f8yQsOaf_W_37KbbLmqCjd7XVnnVwx5Qa58d5ttm-QdbfuW_rSFad-dYd86ZsE0D0wDefIU2llKdaBkui-qCw1BZODnUqX9MA0NQCOC6xA_IMuimbVUgx8aQSgPgmsbGlRUuAH0V3yeX_v09sD37Vn8BUEGUtf5xDM6UgzCRwBiIlU3HAJdA1CQKUSA7EluEfLQjbPuQXB20ip1IpcB1wlKmL3yKwEUWwSqoIkB2etrM6jONdaammA2QQmiRXXOvUIG6SUKVe7HFtonGXdhhyHGKafswxlmznZesQf76r72h1_wb9BBRixWHm7u1A1p5lbyFkaJXMjhTA2FrERQSqYkUzEOZ6IMaHyyBNUn6w_xjraj2wXjyynSRwIjzzrEFh9o8T0nlO5atvs3YfFP4COjyagFw5kK5gOJd2RCvgmrOo1QW5NkGBD1GR4E5V9mJU2-6WicOegxJcPPx2H8aGYsleaatVhIgbmnXGP3O_XyzizyLMFRP8e4ZOVNJn66UhZfO2Kn8fgkdIwfvDn13pIboLmYlqqH4VbZLZsVuYRua6-L4u2edxZiZ82THCF priority: 102 providerName: ProQuest – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZgQYgL0PJooIBBSMAhJbGztnMsqKsiQakoVOUUOX5ApJKsNruIn89M4g2kagVc489RMvbMfCOPZwh5BgzBK1Vi0wzm48xpHwPLMDEwW5NNlQPGrbpmE_LgQJ2c5Ie_A8UzJ_hcpq-CTHfmTe12kL7nKr9MrjAuBAZbs8N3a8sLuitEuB530cyR--mq9A-2eDI_bdrziObZfMk_HNDs5v9--i1yI1BNutvvjQ1yydWb5Nr7cJi-STaCXrf0RSg-_fI2-dI3AaB7oPrfkYfSxlOs86TRPVFdWwomBTuRLum-W8wBcFRhheGf9LharFqKgS1lAOqTvOqWVjUF_8_ukM-zvU9v9uPQfiE2EEQsY1tCsGaZ5Ro4ABAPbaSTGugYhHjGCAexI7g_z1M-LaWHhfXMmNyr0ibSCMP4XTKp4c-3CDWJKMEZG29LlpXWaqsdMJfEicxIa_OI8PWqFCbUJscWGadFd-AmIUbpZVagKIsgyojEw6x5X5vjL_jXuOADFitrdw9gzYqgqEXOxNRppZzPVOZUkivuNFdZiTdeXGoi8hi3S9FfUx3sQ7GLV5JzkSUqIk87BFbXqDF956tetW3x9sPxP4COPo5AzwPINyAOo8OVCfgnrNo1Qm6PkGAjzGh4Czf3WiptkQLxhMBfSA4z1xv-_OEnwzC-FFPyatesOgzjYL65jMi9Xj8GySKPVhDdR0SONGck-vFIXX3riptn4HHyNLt_8Rc_INdh12LKaczSbTJZLlbuIblqfiyrdvGoswi_AEreXsA priority: 102 providerName: Public Library of Science |
| Title | Global Estimates of Prevalent and Incident Herpes Simplex Virus Type 2 Infections in 2012 |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/25608026 https://www.proquest.com/docview/1658107673 https://www.proquest.com/docview/1652396337 https://pubmed.ncbi.nlm.nih.gov/PMC4301914 https://doaj.org/article/9265ea88ef484e80983ea384b0097e1c http://dx.doi.org/10.1371/journal.pone.0114989 |
| Volume | 10 |
| WOSCitedRecordID | wos000348205300007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9NADD9B4YEXxPhaYJQDIQEP6ZJcmrs8rtMqprESdTBtvESX-4BKI62aduLPx06uUYMmjQderKrnRKntO9up_TMh7yBCsEIUODQjsn5spPUhylA-RLYqHgoDEbeoh03wyURcXKTZ1qgvrAlr4IEbwe2nUTI0UghjYxEbEaSCGclEXGAHggkVnr4BTzfJVHMGwy5OEtcox3i47_QyWMxLM8AUIMWx7luOqMbrb0_l3uJqXt0Ucv5dObnlisaPyEMXQ9KD5tl3yB1TPiY7bpdW9IODkv74hFw2kP4UoTR-YVRJ55YulgjxDbemstQU37Vjsy4F5S2AoZohXvBvej1briuKb2hpRDclW2UFHyl48-gp-TY--nr4yXfDFHwFKcHK1wWkXjrSTIJHhzBCKm64hOAKEjalEgOZIDgzy0I2LLgFNdlIqdSKQgdcJSpiz0ivBPHtEqqCpADXqqwuorjQWmppIA4JTBIrrnXqEbaRbK4c0jgOvLjK67_POGQcjaBy1Efu9OERv71q0SBt3MI_QqW1vIiTXX8B1pM768lvsx6PvEaV503Tabvb8wNsME6TOBAeeVtzIFZGicU4P-S6qvLjL-f_wHQ27TC9d0x2DuJQ0jVAwG9CDK4O516HE3a86izvooFupFLlIYSRkMYnnMGVG6O9eflNu4w3xQK70szXNU_E4DBm3CPPGxtvJYtRsYBc3SO8Y_0d0XdXytnPGqo8Bv-RhvGL_6Grl-QB2DeWmvpRuEd6q-XavCL31fVqVi375C6fniO94DUVQMVh2Cf3RkeTbNqvzweg4-wz0JPRAOhpcIKUZzU9A5oNv8MV2fFpdvkHhK5sNg |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF5VBQEXoOVRQ6ELAlEObu31xl4fECrQKlHbUNFSFS5mvbsukYod4oTHn-I3MmOvTY0q4NID1-w4csYz33wTz4OQR8AQMiFSXJrBMpcbmbnAMpQLzFbxnjDAuEW1bCIaDsXRUbw3R340vTBYVtlgYgXUulD4H_m6D6ESUpUwCp6PP7u4NQrfrjYrNGqz2Dbfv0LKVj4bvILn-5ixrc2Dl33XbhVwFXDjqatTyEE004GE0AbxVKrIRBJYBmQuSoUGUiJA9Szwg14aZXC_GVMqzkSqvUiFCgcdAORf4Jx56EV7vfcN8gN2hKFtzwsif91aw9q4yM0aJh4xLpM_Ff6qLQFtLJgfnxTlWUT393rNUwFw69r_prrr5Kql2nSj9o0FMmfyRXJp1xYTLJIFi2slXbXDt5_eIO_qJQh0E6DvE_JwWmQU51xJDM9U5poCpOIm1intm8kYBPZHOGH5Gz0cTWYlxcSeMhCqi9zyko5yCvyH3SRvz-XX3iLzOTz6JUKVF6ZARlSmU8ZTraWWBpibZ0KuIq1jhwSNVSTKzmbHFSEnSfXCMYIcrdZZgraUWFtyiNteNa5nk_xF_gUaXCuLk8WrD4rJcWKBKolZ2DNSCJNxwY3wYhEYGQieYseP8ZVDVtBck7pNt8XHZANbsuOQe8IhDysJnC6SY_nSsZyVZTJ4ffgPQvtvOkJPrFBWgDqUtC0j8JtwallHcrkjCRipOsdL6FyNVsrkl0vAlY3TnH38oD3GL8WSxNwUs0qGBRC-gsght2v_bDWLeYTwWOiQqOO5HdV3T_LRx2q4O4eIG_v8zp9va4Vc7h_s7iQ7g-H2XXIFrBhLcF3mL5P56WRm7pGL6st0VE7uVwhFyYfz9uufE2HMcw |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF5VAVVcgJZHDYUuCAQc3Nhrx7s-IFRoo0aFENFSFS7G3keJVOwQJzz-Gr-OGXsdalQBlx64ZseRPZn55pt4HoQ8AIZghMhwaQYzbqhT4wLLkC4wWxn2hAbGLaplE3w4FEdH8WiJ_Gh6YbCsssHECqhVIfE_8q4PoRJSlYgHXWPLIkbb_WeTzy5ukMI3rc06jdpE9vT3r5C-lU8H2_BbP2Ssv3PwYte1GwZcCTx55qoM8hHFVJBCmIPYmkqueQqMA7IYKSMN6REgvAn8oJdxA_dumJSxEZnyuIwkDj0A-L_AIcfEcsJR730TBQBHosi26gXc71rL2JwUud7EJCTGxfKnQmG1MWARFzqTk6I8i_T-Xrt5Khj2r_zParxKLlsKTrdqn1khSzpfJcuvbJHBKlmxeFfSx3Yo95Nr5F29HIHuACR-Qn5OC0Nx_lWKYZumuaIAtbihdUZ39XQCAvtjnLz8jR6Op_OSYsJPGQjVxW95Scc5BV7ErpO35_K0N0gnBzNYI1R6UQYkRRqVsTBTKlWpBkbn6SiUXKnYIUFjIYm0M9txdchJUr2I5JC71TpL0K4Sa1cOcRdXTeqZJX-Rf47Gt5DFiePVB8X0OLEAlsQs6ulUCG1CEWrhxSLQaSDCDDuBtC8dsoGmm9TtuwvcTLawVTuOQk845H4lgVNHcjS843Relsng9eE_CO2_aQk9skKmAHXI1LaSwDPhNLOW5HpLErBTto7X0NEarZTJL_eAKxsHOvv43uIYvxRLFXNdzCsZFkBYC7hDbta-utAs5hfCY5FDeMuLW6pvn-Tjj9XQ9xAiceyHt_58WxtkGdw5eTkY7t0ml8CIsTLXZf466cymc32HXJRfZuNyercCK0o-nLdb_wTZmdU9 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Global+Estimates+of+Prevalent+and+Incident+Herpes+Simplex+Virus+Type+2+Infections+in+2012&rft.jtitle=PloS+one&rft.au=Looker%2C+Katharine+J.&rft.au=Magaret%2C+Amalia+S.&rft.au=Turner%2C+Katherine+M.+E.&rft.au=Vickerman%2C+Peter&rft.date=2015-01-21&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=10&rft.issue=1&rft.spage=e114989&rft_id=info:doi/10.1371%2Fjournal.pone.0114989&rft.externalDBID=n%2Fa&rft.externalDocID=10_1371_journal_pone_0114989 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |