Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men

Carotid artery plaque is an established marker of subclinical atherosclerosis with pronounced sex-dimorphism. Here, we aimed to identify genetic variants associated with carotid plaque burden (CPB) and to examine potential sex-specific genetic effects on plaque sizes. We defined six operationalizati...

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Bibliographic Details
Published in:	PloS one Vol. 15; no. 5; p. e0233728
Main Authors:	Pott, Janne, Beutner, Frank, Horn, Katrin, Kirsten, Holger, Olischer, Kay, Wirkner, Kerstin, Loeffler, Markus, Scholz, Markus
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 29.05.2020 Public Library of Science (PLoS)
Subjects:	Aged Arteries Arteriosclerosis Arteriosclerosis - genetics Atherosclerosis Biology and Life Sciences Cardiovascular disease Carotid arteries Carotid artery Carotid artery diseases Carotid Artery Diseases - genetics Carotid Artery, External - diagnostic imaging Carotid Artery, External - pathology Carotid Artery, Internal - diagnostic imaging Carotid Artery, Internal - pathology Civilization Cohort Studies Development and progression Dimorphism Disease sex factors Epidemiology Estrogens Female Gene expression Gene loci Genetic aspects Genetic diversity Genetic effects Genetic Predisposition to Disease - genetics Genetic variance Genetic variation Genetics Genome-Wide Association Study Genomes Health aspects Health informatics Health risks Humans Interleukin 5 Interleukin-5 - genetics Interleukin-5 - physiology Male Medicine and Health Sciences Men Middle Aged Plaque, Atherosclerotic - genetics Plaques Regulatory sequences Sex Sex Characteristics Sex Factors Sexual dimorphism Single-nucleotide polymorphism Ultrasonic imaging Variance analysis Women Germany
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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