Vascular Factors and Multiple Measures of Early Brain Health: CARDIA Brain MRI Study

To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF). Cross-sectional brain Magnetic Resonance I (MRI) study. Community based cohort in three U.S. sites. A Caucasian and African-American sub-sample (n= 680; mean age 50.3 yrs) attending...

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Vydané v:	PloS one Ročník 10; číslo 3; s. e0122138
Hlavní autori:	Launer, Lenore J., Lewis, Cora E., Schreiner, Pamela J., Sidney, Steve, Battapady, Harsha, Jacobs, David R., Lim, Kelvin O., D’Esposito, Mark, Zhang, Qian, Reis, Jared, Davatzikos, Christos, Bryan, R. Nick
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 26.03.2015 Public Library of Science (PLoS)
Predmet:	Adolescent Adult Adults African Americans Aging Anisotropy Blood flow Blood pressure Body mass Brain Brain - blood supply Brain - pathology Brain - physiopathology Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - pathology Cerebral blood flow Cerebrospinal fluid Cognition Cognitive ability Cohort Studies Coronary artery Cross-Sectional Studies Dementia Dementia disorders Demographics Design factors Diabetes Diabetes mellitus Disease prevention Epidemiology Executive function Female Follow-Up Studies Functional anatomy Health risks Humans Hypertension Image Processing, Computer-Assisted Laboratories Magnetic resonance Magnetic Resonance Imaging Male Memory Middle age Middle Aged Morphology NMR Nuclear magnetic resonance Perfusion Physiology Public health Review boards Risk analysis Risk Factors Smoking Structure-function relationships Studies Substantia alba Substantia grisea Systematic review United States - epidemiology Young Adult Young adults United States Northern California New York California United States > US
ISSN:	1932-6203, 1932-6203
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Popis
Shrnutí:	To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF). Cross-sectional brain Magnetic Resonance I (MRI) study. Community based cohort in three U.S. sites. A Caucasian and African-American sub-sample (n= 680; mean age 50.3 yrs) attending the 25 year follow-up exam of the Coronary Artery Risk Development in Young Adults Study. 3T brain MR images processed for quantitative estimates of: total brain (TBV) and abnormal white matter (AWM) volume; white matter fractional anisotropy (WM-FA); and gray matter cerebral blood flow (GM-CBF). Total intracranial volume is TBV plus cerebral spinal fluid (TICV). A Global Cognitive Function (GCF) score was derived from tests of speed, memory and executive function. Adjusting for TICV and demographic factors, current smoking was significantly associated with lower GM-CBF and TBV, and more AWM (all <0.05); SA with lower GM-CBF, WM-FA and TBV (p=0.01); increasing BMI with decreasing GM-CBF (p<0003); hypertension with lower GM-CBF, WM-FA, and TBV and higher AWM (all <0.05); and diabetes with lower TBV (p=0.007). The GCS was lower as TBV decreased, AWM increased, and WM-FA (all p<0.01). In middle age adults, CVRF are associated with brain health, reflected in MRI measures of structure and perfusion, and cognitive functioning. These findings suggest markers of mid-life cardiovascular and brain health should be considered as indication for early intervention and future risk of late-life cerebrovascular disease and dementia.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: LJL CEL PJS SSCD RNB. Performed the experiments: KOL MDE CEL PJS SS. Analyzed the data: HB QZ DJ. Contributed reagents/materials/analysis tools: HB CD RNB. Wrote the paper: LJL CEL PJS SS RNB JR.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0122138