Vascular Factors and Multiple Measures of Early Brain Health: CARDIA Brain MRI Study
To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF). Cross-sectional brain Magnetic Resonance I (MRI) study. Community based cohort in three U.S. sites. A Caucasian and African-American sub-sample (n= 680; mean age 50.3 yrs) attending...
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| Veröffentlicht in: | PloS one Jg. 10; H. 3; S. e0122138 |
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Public Library of Science
26.03.2015
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| Abstract | To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF).
Cross-sectional brain Magnetic Resonance I (MRI) study.
Community based cohort in three U.S. sites.
A Caucasian and African-American sub-sample (n= 680; mean age 50.3 yrs) attending the 25 year follow-up exam of the Coronary Artery Risk Development in Young Adults Study.
3T brain MR images processed for quantitative estimates of: total brain (TBV) and abnormal white matter (AWM) volume; white matter fractional anisotropy (WM-FA); and gray matter cerebral blood flow (GM-CBF). Total intracranial volume is TBV plus cerebral spinal fluid (TICV). A Global Cognitive Function (GCF) score was derived from tests of speed, memory and executive function.
Adjusting for TICV and demographic factors, current smoking was significantly associated with lower GM-CBF and TBV, and more AWM (all <0.05); SA with lower GM-CBF, WM-FA and TBV (p=0.01); increasing BMI with decreasing GM-CBF (p<0003); hypertension with lower GM-CBF, WM-FA, and TBV and higher AWM (all <0.05); and diabetes with lower TBV (p=0.007). The GCS was lower as TBV decreased, AWM increased, and WM-FA (all p<0.01).
In middle age adults, CVRF are associated with brain health, reflected in MRI measures of structure and perfusion, and cognitive functioning. These findings suggest markers of mid-life cardiovascular and brain health should be considered as indication for early intervention and future risk of late-life cerebrovascular disease and dementia. |
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| AbstractList | Objective To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF). Design Cross-sectional brain Magnetic Resonance I (MRI) study. Setting Community based cohort in three U.S. sites. Participants A Caucasian and African-American sub-sample (n= 680; mean age 50.3 yrs) attending the 25 year follow-up exam of the Coronary Artery Risk Development in Young Adults Study. Primary and Secondary Outcomes 3T brain MR images processed for quantitative estimates of: total brain (TBV) and abnormal white matter (AWM) volume; white matter fractional anisotropy (WM-FA); and gray matter cerebral blood flow (GM-CBF). Total intracranial volume is TBV plus cerebral spinal fluid (TICV). A Global Cognitive Function (GCF) score was derived from tests of speed, memory and executive function. Results Adjusting for TICV and demographic factors, current smoking was significantly associated with lower GM-CBF and TBV, and more AWM (all <0.05); SA with lower GM-CBF, WM-FA and TBV (p=0.01); increasing BMI with decreasing GM-CBF (p<0003); hypertension with lower GM-CBF, WM-FA, and TBV and higher AWM (all <0.05); and diabetes with lower TBV (p=0.007). The GCS was lower as TBV decreased, AWM increased, and WM-FA (all p<0.01). Conclusion In middle age adults, CVRF are associated with brain health, reflected in MRI measures of structure and perfusion, and cognitive functioning. These findings suggest markers of mid-life cardiovascular and brain health should be considered as indication for early intervention and future risk of late-life cerebrovascular disease and dementia. To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF). Cross-sectional brain Magnetic Resonance I (MRI) study. Community based cohort in three U.S. sites. A Caucasian and African-American sub-sample (n= 680; mean age 50.3 yrs) attending the 25 year follow-up exam of the Coronary Artery Risk Development in Young Adults Study. 3T brain MR images processed for quantitative estimates of: total brain (TBV) and abnormal white matter (AWM) volume; white matter fractional anisotropy (WM-FA); and gray matter cerebral blood flow (GM-CBF). Total intracranial volume is TBV plus cerebral spinal fluid (TICV). A Global Cognitive Function (GCF) score was derived from tests of speed, memory and executive function. Adjusting for TICV and demographic factors, current smoking was significantly associated with lower GM-CBF and TBV, and more AWM (all <0.05); SA with lower GM-CBF, WM-FA and TBV (p=0.01); increasing BMI with decreasing GM-CBF (p<0003); hypertension with lower GM-CBF, WM-FA, and TBV and higher AWM (all <0.05); and diabetes with lower TBV (p=0.007). The GCS was lower as TBV decreased, AWM increased, and WM-FA (all p<0.01). In middle age adults, CVRF are associated with brain health, reflected in MRI measures of structure and perfusion, and cognitive functioning. These findings suggest markers of mid-life cardiovascular and brain health should be considered as indication for early intervention and future risk of late-life cerebrovascular disease and dementia. Objective To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF). Design Cross-sectional brain Magnetic Resonance I (MRI) study. Setting Community based cohort in three U.S. sites. Participants A Caucasian and African-American sub-sample (n= 680; mean age 50.3 yrs) attending the 25 year follow-up exam of the Coronary Artery Risk Development in Young Adults Study. Primary and Secondary Outcomes 3T brain MR images processed for quantitative estimates of: total brain (TBV) and abnormal white matter (AWM) volume; white matter fractional anisotropy (WM-FA); and gray matter cerebral blood flow (GM-CBF). Total intracranial volume is TBV plus cerebral spinal fluid (TICV). A Global Cognitive Function (GCF) score was derived from tests of speed, memory and executive function. Results Adjusting for TICV and demographic factors, current smoking was significantly associated with lower GM-CBF and TBV, and more AWM (all <0.05); SA with lower GM-CBF, WM-FA and TBV (p=0.01); increasing BMI with decreasing GM-CBF (p<0003); hypertension with lower GM-CBF, WM-FA, and TBV and higher AWM (all <0.05); and diabetes with lower TBV (p=0.007). The GCS was lower as TBV decreased, AWM increased, and WM-FA (all p<0.01). Conclusion In middle age adults, CVRF are associated with brain health, reflected in MRI measures of structure and perfusion, and cognitive functioning. These findings suggest markers of mid-life cardiovascular and brain health should be considered as indication for early intervention and future risk of late-life cerebrovascular disease and dementia. OBJECTIVETo identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF).DESIGNCross-sectional brain Magnetic Resonance I (MRI) study.SETTINGCommunity based cohort in three U.S. sites.PARTICIPANTSA Caucasian and African-American sub-sample (n= 680; mean age 50.3 yrs) attending the 25 year follow-up exam of the Coronary Artery Risk Development in Young Adults Study.PRIMARY AND SECONDARY OUTCOMES3T brain MR images processed for quantitative estimates of: total brain (TBV) and abnormal white matter (AWM) volume; white matter fractional anisotropy (WM-FA); and gray matter cerebral blood flow (GM-CBF). Total intracranial volume is TBV plus cerebral spinal fluid (TICV). A Global Cognitive Function (GCF) score was derived from tests of speed, memory and executive function.RESULTSAdjusting for TICV and demographic factors, current smoking was significantly associated with lower GM-CBF and TBV, and more AWM (all <0.05); SA with lower GM-CBF, WM-FA and TBV (p=0.01); increasing BMI with decreasing GM-CBF (p<0003); hypertension with lower GM-CBF, WM-FA, and TBV and higher AWM (all <0.05); and diabetes with lower TBV (p=0.007). The GCS was lower as TBV decreased, AWM increased, and WM-FA (all p<0.01).CONCLUSIONIn middle age adults, CVRF are associated with brain health, reflected in MRI measures of structure and perfusion, and cognitive functioning. These findings suggest markers of mid-life cardiovascular and brain health should be considered as indication for early intervention and future risk of late-life cerebrovascular disease and dementia. To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF). Cross-sectional brain Magnetic Resonance I (MRI) study. Community based cohort in three U.S. sites. A Caucasian and African-American sub-sample (n= 680; mean age 50.3 yrs) attending the 25 year follow-up exam of the Coronary Artery Risk Development in Young Adults Study. Adjusting for TICV and demographic factors, current smoking was significantly associated with lower GM-CBF and TBV, and more AWM (all <0.05); SA with lower GM-CBF, WM-FA and TBV (p=0.01); increasing BMI with decreasing GM-CBF (p<0003); hypertension with lower GM-CBF, WM-FA, and TBV and higher AWM (all <0.05); and diabetes with lower TBV (p=0.007). The GCS was lower as TBV decreased, AWM increased, and WM-FA (all p<0.01). In middle age adults, CVRF are associated with brain health, reflected in MRI measures of structure and perfusion, and cognitive functioning. These findings suggest markers of mid-life cardiovascular and brain health should be considered as indication for early intervention and future risk of late-life cerebrovascular disease and dementia. |
| Audience | Academic |
| Author | Davatzikos, Christos Battapady, Harsha Lim, Kelvin O. Sidney, Steve D’Esposito, Mark Reis, Jared Zhang, Qian Jacobs, David R. Launer, Lenore J. Lewis, Cora E. Schreiner, Pamela J. Bryan, R. Nick |
| AuthorAffiliation | 5 Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States of America 6 Department of Radiology, University of Minnesota, Minneapolis, MN, United States of America 2 University of Alabama, Birmingham, AL, United States of America 4 Division of Research, Kaiser Permanente Northern California, Oakland, CA, United States of America 7 Department of Radiology, University of California, Berkeley, Berkeley, CA, United States of America University Medical Center Rotterdam, NETHERLANDS 8 Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD, United States of America 1 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, United States of America 3 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, United States of America |
| AuthorAffiliation_xml | – name: University Medical Center Rotterdam, NETHERLANDS – name: 4 Division of Research, Kaiser Permanente Northern California, Oakland, CA, United States of America – name: 8 Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD, United States of America – name: 1 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, United States of America – name: 6 Department of Radiology, University of Minnesota, Minneapolis, MN, United States of America – name: 3 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, United States of America – name: 7 Department of Radiology, University of California, Berkeley, Berkeley, CA, United States of America – name: 5 Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States of America – name: 2 University of Alabama, Birmingham, AL, United States of America |
| Author_xml | – sequence: 1 givenname: Lenore J. surname: Launer fullname: Launer, Lenore J. – sequence: 2 givenname: Cora E. surname: Lewis fullname: Lewis, Cora E. – sequence: 3 givenname: Pamela J. surname: Schreiner fullname: Schreiner, Pamela J. – sequence: 4 givenname: Steve surname: Sidney fullname: Sidney, Steve – sequence: 5 givenname: Harsha surname: Battapady fullname: Battapady, Harsha – sequence: 6 givenname: David R. surname: Jacobs fullname: Jacobs, David R. – sequence: 7 givenname: Kelvin O. surname: Lim fullname: Lim, Kelvin O. – sequence: 8 givenname: Mark surname: D’Esposito fullname: D’Esposito, Mark – sequence: 9 givenname: Qian surname: Zhang fullname: Zhang, Qian – sequence: 10 givenname: Jared surname: Reis fullname: Reis, Jared – sequence: 11 givenname: Christos surname: Davatzikos fullname: Davatzikos, Christos – sequence: 12 givenname: R. Nick surname: Bryan fullname: Bryan, R. Nick |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25812012$$D View this record in MEDLINE/PubMed |
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| DOI | 10.1371/journal.pone.0122138 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: LJL CEL PJS SSCD RNB. Performed the experiments: KOL MDE CEL PJS SS. Analyzed the data: HB QZ DJ. Contributed reagents/materials/analysis tools: HB CD RNB. Wrote the paper: LJL CEL PJS SS RNB JR. |
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| Snippet | To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF).
Cross-sectional brain Magnetic Resonance... Objective To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF). Design Cross-sectional brain... To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF). Cross-sectional brain Magnetic Resonance... OBJECTIVETo identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF).DESIGNCross-sectional brain... ObjectiveTo identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF).DesignCross-sectional brain... Objective To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF). Design Cross-sectional brain... |
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| SubjectTerms | Adolescent Adult Adults African Americans Aging Anisotropy Blood flow Blood pressure Body mass Brain Brain - blood supply Brain - pathology Brain - physiopathology Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - pathology Cerebral blood flow Cerebrospinal fluid Cognition Cognitive ability Cohort Studies Coronary artery Cross-Sectional Studies Dementia Dementia disorders Demographics Design factors Diabetes Diabetes mellitus Disease prevention Epidemiology Executive function Female Follow-Up Studies Functional anatomy Health risks Humans Hypertension Image Processing, Computer-Assisted Laboratories Magnetic resonance Magnetic Resonance Imaging Male Memory Middle age Middle Aged Morphology NMR Nuclear magnetic resonance Perfusion Physiology Public health Review boards Risk analysis Risk Factors Smoking Structure-function relationships Studies Substantia alba Substantia grisea Systematic review United States - epidemiology Young Adult Young adults |
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| Title | Vascular Factors and Multiple Measures of Early Brain Health: CARDIA Brain MRI Study |
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