Heat Shock Protein 27 Plays a Pivotal Role in Myofibroblast Differentiation and in the Development of Bleomycin-Induced Pulmonary Fibrosis

Heat shock protein 27 (HSP27) is a member of the small molecular weight HSP family. Upon treatment with transforming growth factor β1 (TGF-β1), we observed upregulation of HSP27 along with that of α-smooth muscle actin (α-SMA), a marker of myofibroblast differentiation, in cultured human and mouse l...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 2; p. e0148998
Main Authors:	Park, Ah-Mee, Kanai, Kyosuke, Itoh, Tatsuki, Sato, Takao, Tsukui, Tatsuya, Inagaki, Yutaka, Selman, Moises, Matsushima, Kouji, Yoshie, Osamu
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 09.02.2016 Public Library of Science (PLoS)
Subjects:	Actin Actins - physiology Aged Alveoli Animal tissues Animals Antibiotics Biocompatibility Biology and Life Sciences Biomedical materials Bleomycin Bleomycin - pharmacology Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line Cell survival Collagen (type I) Collagen Type I - physiology Differentiation E-cadherin Epithelial cells Female Fibroblasts Fibroblasts - drug effects Fibroblasts - physiology Fibronectin Fibronectins - physiology Fibrosis Gene Knockdown Techniques Genetic aspects Growth factors Heat shock proteins HSP27 Heat-Shock Proteins - physiology Hsp27 protein Humans Idiopathic Pulmonary Fibrosis - physiopathology Immunoglobulins Kidneys Localization Lung diseases Macrophages Male Medical prognosis Medicine and Health Sciences Mice Molecular weight Myofibroblasts - physiology Osteopontin Osteopontin - physiology Physiological aspects Polymerase Chain Reaction Polymerization Preventive medicine Pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - physiopathology Research and Analysis Methods Respiratory tract Risk factors Rodents siRNA Smooth muscle Transforming growth factor Transforming Growth Factor beta1 - physiology Transforming growth factor-b1 University faculty Mexico Japan
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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