Comparison of Diagnostic Accuracy of Microscopy and Flow Cytometry in Evaluating N-Methyl-D-Aspartate Receptor Antibodies in Serum Using a Live Cell-Based Assay

N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune neurological disease, diagnosed by a specific autoantibody against NMDAR. Antibody testing using commercially available cell-based assays (CBA) or immunohistochemistry on rat brain tissue has proven high specificity and sensitivity....

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 3; p. e0122037
Main Authors:	Ramberger, Melanie, Peschl, Patrick, Schanda, Kathrin, Irschick, Regina, Höftberger, Romana, Deisenhammer, Florian, Rostásy, Kevin, Berger, Thomas, Dalmau, Josep, Reindl, Markus
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 27.03.2015 Public Library of Science (PLoS)
Subjects:	Adolescent Adult Analysis Animal tissues Anti-N-Methyl-D-Aspartate Receptor Encephalitis - blood Antibodies Antigens Aspartate Assaying Autoantibodies Autoantibodies - blood Autoimmune diseases Autoimmunity Brain Case-Control Studies Child Confidence intervals Diagnostic systems Disease Encephalitis Female Flow cytometry Flow Cytometry - methods Fluorescence Glutamate receptors Glutamic acid receptors HEK293 Cells Hospitals Humans Immunofluorescence Immunoglobulins Immunohistochemistry Laboratories Male Medical diagnosis Microscopy Microscopy, Fluorescence - methods Multiple sclerosis N-methyl-D-aspartate N-Methyl-D-aspartic acid receptors Neurological diseases Neurology Patients Performance evaluation Receptors, N-Methyl-D-Aspartate - immunology Rodents Sensitivity Sensitivity analysis Sensitivity and Specificity Serologic Tests - methods Signal transduction Austria Germany Spain
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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