Reference values for the cervical spinal canal and the vertebral bodies by MRI in a general population

To provide population-based reference values for cervical spinal canal parameters and vertebral body (VB) width and to study their associations with sex, age, body height, body weight and body mass index (BMI) using MRI. Cross-sectional analyses included data from 2,453 participants, aged 21-89 year...

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Bibliographic Details
Published in:PloS one Vol. 14; no. 9; p. e0222682
Main Authors: Nell, Christopher, Bülow, Robin, Hosten, Norbert, Schmidt, Carsten Oliver, Hegenscheid, Katrin
Format: Journal Article
Language:English
Published: United States Public Library of Science 27.09.2019
Public Library of Science (PLoS)
Subjects:
Adult
Adults
Age
Age Factors
Aged
Aged, 80 and over
Biology and Life Sciences
Body Height
Body mass
Body Mass Index
Body size
Body Weight
Cervical Vertebrae - anatomy & histology
Cervical Vertebrae - diagnostic imaging
College football
Cross-Sectional Studies
Diagnosis
Diagnostic imaging
Engineering and Technology
Female
Females
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - standards
Male
Males
Medical imaging
Medicine and Health Sciences
Middle Aged
Neurosurgery
NMR
Nuclear magnetic resonance
Parameters
Physiological aspects
Population
Population studies
Quality of life
Reference Values
Research and Analysis Methods
Risk factors
Schmidt, Oliver
Sex
Sex Factors
Ships
Spinal Canal - anatomy & histology
Spinal Canal - diagnostic imaging
Spinal cord
Spinal diseases
Spine
Spine (cervical)
Studies
Vertebrae
Young Adult
Germany
ISSN:1932-6203, 1932-6203
Online Access:Get full text
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Summary:To provide population-based reference values for cervical spinal canal parameters and vertebral body (VB) width and to study their associations with sex, age, body height, body weight and body mass index (BMI) using MRI. Cross-sectional analyses included data from 2,453 participants, aged 21-89 years, of the population-based Study of Health in Pomerania (SHIP) who underwent whole-body MRI at 1.5 Tesla between July 2008 and March 2011. A standardised reading was performed for the C2-C7 cervical spine levels at sagittal T2 TSE weighted sequences. Reference intervals for spinal canal parameters were similar in males and females, while VB width was on average 2.1-2.2 mm larger in males. Age effects were only substantial regarding VB width with a 0.5 mm per ten-year age increase. Body height effects were only substantial regarding the osseous spinal canal and VB width. Body weight and BMI effects are mostly not substantial. Our study provides MRI-based reference values for the cervical spinal canal parameters in an adult Caucasian population. Except for VB width, associations with sex, age and somatometric measures are mostly small and thus have only limited clinical implications. Some available cut-off values may need a revision because they likely overestimate risks.
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Competing Interests: I have read the journal's policy and the authors of this manuscript have the following competing interests: This study was supported by the commercial funder Siemens Healthcare. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0222682