Nanocytological Field Carcinogenesis Detection to Mitigate Overdiagnosis of Prostate Cancer: A Proof of Concept Study

To determine whether nano-architectural interrogation of prostate field carcinogenesis can be used to predict prognosis in patients with early stage (Gleason 6) prostate cancer (PCa), which is mostly indolent but frequently unnecessarily treated. We previously developed partial wave spectroscopic mi...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 2; p. e0115999
Main Authors:	Roy, Hemant K., Brendler, Charles B., Subramanian, Hariharan, Zhang, Di, Maneval, Charles, Chandler, John, Bowen, Leah, Kaul, Karen L., Helfand, Brian T., Wang, Chi-Hsiung, Quinn, Margo, Petkewicz, Jacqueline, Paterakos, Michael, Backman, Vadim
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 23.02.2015 Public Library of Science (PLoS)
Subjects:	Aged Biomedical engineering Cancer Cancer research Carcinogenesis Carcinogenesis - pathology Carcinogens Case-Control Studies Cellular structure Demographics Disease control Early Detection of Cancer Engineering Epithelial cells Esophagus Gene expression Heterogeneity Humans Interrogation Male Mathematical morphology Medical diagnosis Medical Overuse Medical prognosis Medical screening Microscopy Middle Aged Mucosa Neoplasm Grading Prognosis Prostate - pathology Prostate cancer Prostatic Neoplasms - diagnosis Prostatic Neoplasms - pathology Questioning Smoking Spatial heterogeneity Surgery Surveillance United States > US Illinois
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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