Parallel Analysis of mRNA and microRNA Microarray Profiles to Explore Functional Regulatory Patterns in Polycystic Kidney Disease: Using PKD/Mhm Rat Model

Autosomal polycystic kidney disease (ADPKD) is a frequent monogenic renal disease, characterised by fluid-filled cysts that are thought to result from multiple deregulated pathways such as cell proliferation and apoptosis. MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of...

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Veröffentlicht in:	PloS one Jg. 8; H. 1; S. e53780
Hauptverfasser:	Dweep, Harsh, Sticht, Carsten, Kharkar, Asawari, Pandey, Priyanka, Gretz, Norbert
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 10.01.2013 Public Library of Science (PLoS)
Schlagworte:	Animal models Animals Apoptosis Aquaporins Binding sites Biological activity Biology Cell cycle Cell growth Cell proliferation Cysts Deoxyribonucleic acid Deregulation Disease Models, Animal DNA DNA biosynthesis DNA microarrays DNA replication Epidemiology Extracellular matrix Fibrosis Fluids Gene expression Gene Expression Profiling Genes Genetic aspects Genomics Humans Kidney diseases Kidney transplantation Kidneys Medical research Medicine Messenger RNA Metabolic Networks and Pathways - genetics Metabolic pathways Metabolism Microarray Analysis MicroRNA MicroRNAs MicroRNAs - genetics miRNA mRNA Pathogenesis Polycystic kidney Polycystic kidney disease Polycystic Kidney Diseases - genetics Polycystic Kidney Diseases - pathology Rats Ribonucleic acid RNA RNA, Messenger - genetics Rodents Signal transduction Signal Transduction - genetics Signaling Transforming growth factors Up-Regulation Wnt protein
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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