Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation

Environmental factors such as tobacco smoking may have long-lasting effects on DNA methylation patterns, which might lead to changes in gene expression and in a broader context to the development or progression of various diseases. We conducted an epigenome-wide association study (EWAs) comparing cu...

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Veröffentlicht in:	PloS one Jg. 8; H. 5; S. e63812
Hauptverfasser:	Zeilinger, Sonja, Kühnel, Brigitte, Klopp, Norman, Baurecht, Hansjörg, Kleinschmidt, Anja, Gieger, Christian, Weidinger, Stephan, Lattka, Eva, Adamski, Jerzy, Peters, Annette, Strauch, Konstantin, Waldenberger, Melanie, Illig, Thomas
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 17.05.2013 Public Library of Science (PLoS)
Schlagworte:	Adult Aged Alkaline Phosphatase - genetics Analysis of Variance Basic Helix-Loop-Helix Transcription Factors - genetics Bioinformatics Biology Cancer Cardiovascular disease Change detection CpG Islands - genetics Deoxyribonucleic acid Dermatology Development and progression DNA DNA methylation DNA Methylation - drug effects Electrophoretic Mobility Shift Assay Environmental changes Environmental factors Environmental health Epidemiology Epigenetics Epigenomics - methods Female Gene expression Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Genes Genetic research Genetics Genome, Human - drug effects Genome, Human - genetics Genomes Genomics GPI-Linked Proteins - genetics Humans Isoenzymes - genetics Linear Models Male Medical research Medicine Methylation Middle Aged Oligonucleotide Array Sequence Analysis Phosphatase Population Protein binding Receptors, Thrombin - genetics Repressor Proteins - genetics Sex Factors Smokers Smoking Smoking - adverse effects Smoking Cessation - statistics & numerical data Studies Time Factors Tobacco Tobacco smoking Germany
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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