Lactobacillus johnsonii N6.2 Mitigates the Development of Type 1 Diabetes in BB-DP Rats

The intestinal epithelium is a barrier that composes one of the most immunologically active surfaces of the body due to constant exposure to microorganisms as well as an infinite diversity of food antigens. Disruption of intestinal barrier function and aberrant mucosal immune activation have been im...

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Bibliographic Details
Published in:	PloS one Vol. 5; no. 5; p. e10507
Main Authors:	Valladares, Ricardo, Sankar, Dhyana, Li, Nan, Williams, Emily, Lai, Kin-Kwan, Abdelgeliel, Asmaa Sayed, Gonzalez, Claudio F., Wasserfall, Clive H., Larkin, Joseph, Schatz, Desmond, Atkinson, Mark A., Triplett, Eric W., Neu, Josef, Lorca, Graciela L.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 06.05.2010 Public Library of Science (PLoS)
Subjects:	Aberration Alzheimer's disease Animals Antibiotics Antigens Bacteria Bacteroidetes Comparative analysis Cyclooxygenase-2 Cytokines Cytokines - genetics Cytokines - metabolism Diabetes Diabetes and Endocrinology/Type 1 Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - microbiology Diabetes Mellitus, Type 1 - pathology Digestive system Digestive tract Disruption Epithelium Feeding Behavior Female Firmicutes Gastrointestinal system Gastrointestinal tract Gastrointestinal Tract - microbiology Gastrointestinal Tract - pathology Gene expression Hypotheses Ileum Immune response Immunology Incidence Inflammation Inflammation Mediators - metabolism Intestinal microflora Intestine Kaplan-Meier Estimate Laboratories Lactobacillus Lactobacillus - physiology Male Membrane Proteins - metabolism Metabolism Metagenome Microbiology/Applied Microbiology Microbiology/Medical Microbiology Microbiota (Symbiotic organisms) Microorganisms Mucosal immunity Nitric-oxide synthase Oxidative stress Oxidative Stress - genetics Pathogenesis Pediatrics Prostate Proteins Rats Rats, Inbred BB RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Science Tight Junctions - metabolism Type 1 diabetes Weaning γ-Interferon Florida United States > US
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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