Infusion of gliotoxins or a gap junction blocker in the prelimbic cortex increases alcohol preference in Wistar rats
Postmortem research has revealed that there is a lower density of glial cells in regions of the prefrontal cortex (PFC) of uncomplicated alcoholics when compared with control subjects. Impairment of astrocyte function in the PFC may contribute to malfunction in circuits involved in emotion- and rewa...
Saved in:
| Published in: | Journal of psychopharmacology (Oxford) Vol. 23; no. 5; p. 550 |
|---|---|
| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
01.07.2009
|
| Subjects: | |
| ISSN: | 0269-8811 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Postmortem research has revealed that there is a lower density of glial cells in regions of the prefrontal cortex (PFC) of uncomplicated alcoholics when compared with control subjects. Impairment of astrocyte function in the PFC may contribute to malfunction in circuits involved in emotion- and reward-related subcortical centers, heavily connected with the PFC and directly involved in the pathophysiology of addictive behaviours. The hypothesis was tested that infusion of gliotoxins known to injure astrocytes or of a gap junction blocker into the prelimbic area of the rat PFC results in increased preference for ethanol in rats exposed to free choice between water and 10% ethanol. Fluorocitric acid, L-alpha-aminoadipic acid (AAD) or the gap junction blocker 18-alpha-glycyrrhetinic acid (AGA) were bilaterally infused once into the rat prelimbic cortex and alcohol preference (ratio of 10% ethanol consumed to total liquid ingested) was measured before and after infusion. Infusion of AAD or AGA dissolved in their vehicles, but not of their vehicles alone, resulted in significant transient increase of preference for 10% ethanol. The present data suggest that impaired integrity of glial cells or the gap junctional communication between them in the rat PFC may contribute to changes in ethanol preference. |
|---|---|
| AbstractList | Postmortem research has revealed that there is a lower density of glial cells in regions of the prefrontal cortex (PFC) of uncomplicated alcoholics when compared with control subjects. Impairment of astrocyte function in the PFC may contribute to malfunction in circuits involved in emotion- and reward-related subcortical centers, heavily connected with the PFC and directly involved in the pathophysiology of addictive behaviours. The hypothesis was tested that infusion of gliotoxins known to injure astrocytes or of a gap junction blocker into the prelimbic area of the rat PFC results in increased preference for ethanol in rats exposed to free choice between water and 10% ethanol. Fluorocitric acid, L-alpha-aminoadipic acid (AAD) or the gap junction blocker 18-alpha-glycyrrhetinic acid (AGA) were bilaterally infused once into the rat prelimbic cortex and alcohol preference (ratio of 10% ethanol consumed to total liquid ingested) was measured before and after infusion. Infusion of AAD or AGA dissolved in their vehicles, but not of their vehicles alone, resulted in significant transient increase of preference for 10% ethanol. The present data suggest that impaired integrity of glial cells or the gap junctional communication between them in the rat PFC may contribute to changes in ethanol preference. Postmortem research has revealed that there is a lower density of glial cells in regions of the prefrontal cortex (PFC) of uncomplicated alcoholics when compared with control subjects. Impairment of astrocyte function in the PFC may contribute to malfunction in circuits involved in emotion- and reward-related subcortical centers, heavily connected with the PFC and directly involved in the pathophysiology of addictive behaviours. The hypothesis was tested that infusion of gliotoxins known to injure astrocytes or of a gap junction blocker into the prelimbic area of the rat PFC results in increased preference for ethanol in rats exposed to free choice between water and 10% ethanol. Fluorocitric acid, L-alpha-aminoadipic acid (AAD) or the gap junction blocker 18-alpha-glycyrrhetinic acid (AGA) were bilaterally infused once into the rat prelimbic cortex and alcohol preference (ratio of 10% ethanol consumed to total liquid ingested) was measured before and after infusion. Infusion of AAD or AGA dissolved in their vehicles, but not of their vehicles alone, resulted in significant transient increase of preference for 10% ethanol. The present data suggest that impaired integrity of glial cells or the gap junctional communication between them in the rat PFC may contribute to changes in ethanol preference.Postmortem research has revealed that there is a lower density of glial cells in regions of the prefrontal cortex (PFC) of uncomplicated alcoholics when compared with control subjects. Impairment of astrocyte function in the PFC may contribute to malfunction in circuits involved in emotion- and reward-related subcortical centers, heavily connected with the PFC and directly involved in the pathophysiology of addictive behaviours. The hypothesis was tested that infusion of gliotoxins known to injure astrocytes or of a gap junction blocker into the prelimbic area of the rat PFC results in increased preference for ethanol in rats exposed to free choice between water and 10% ethanol. Fluorocitric acid, L-alpha-aminoadipic acid (AAD) or the gap junction blocker 18-alpha-glycyrrhetinic acid (AGA) were bilaterally infused once into the rat prelimbic cortex and alcohol preference (ratio of 10% ethanol consumed to total liquid ingested) was measured before and after infusion. Infusion of AAD or AGA dissolved in their vehicles, but not of their vehicles alone, resulted in significant transient increase of preference for 10% ethanol. The present data suggest that impaired integrity of glial cells or the gap junctional communication between them in the rat PFC may contribute to changes in ethanol preference. |
| Author | Miguel-Hidalgo, J Shoyama, Y Wanzo, V |
| Author_xml | – sequence: 1 givenname: J surname: Miguel-Hidalgo fullname: Miguel-Hidalgo, J email: jmiguel-hidalgo@psychiatry.umsmed.edu organization: Psychiatry and Human Behaviour, University of Mississippi Medical Center, Jackson, MS, USA. jmiguel-hidalgo@psychiatry.umsmed.edu – sequence: 2 givenname: Y surname: Shoyama fullname: Shoyama, Y – sequence: 3 givenname: V surname: Wanzo fullname: Wanzo, V |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18562436$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1kDtPwzAUhT0U0QfsTMgTW8E3iR8ZUcWjUiUWEGPlODetS2IH25HKv6cRZbrSd75zhjsnE-cdEnID7B5AygeWiVIpAKZYCUwWEzIb0XJkUzKP8cAYiELwSzIFxUVW5GJG0to1Q7TeUd_QXWt98kfrIvWBarrTPT0MzqQxr1pvvjBQ62jaI-0DtrarrKHGh4THEzcBdcRIdWv83rej0mBAZ3AsfdqYdKBBp3hFLhrdRrw-3wX5eH56X70uN28v69XjZmkkF2mpoeECSlNyqTiUtRaszk1jMM95CUJIVVRZLkqEOpcC6kLxCqAqsJbaFDnPFuTub7cP_nvAmLadjQbbVjv0Q9wKmSulGJzE27M4VB3W2z7YToef7f-fsl9d3Gsr |
| CitedBy_id | crossref_primary_10_1038_s41598_019_47454_4 crossref_primary_10_1016_j_neubiorev_2011_05_015 crossref_primary_10_1016_j_biopsych_2013_03_032 crossref_primary_10_1016_j_pnpbp_2024_111009 crossref_primary_10_3390_ijms25126357 crossref_primary_10_1016_j_pneurobio_2015_09_003 crossref_primary_10_1016_j_jpsychires_2014_04_007 crossref_primary_10_1038_s41397_017_0012_2 crossref_primary_10_3389_fncel_2015_00468 crossref_primary_10_1038_npp_2014_135 crossref_primary_10_1016_j_pbb_2018_12_007 crossref_primary_10_1111_acer_12683 crossref_primary_10_1038_s42003_019_0492_5 crossref_primary_10_1111_acer_13168 crossref_primary_10_1016_j_bbr_2025_115640 crossref_primary_10_1093_ijnp_pyab052 crossref_primary_10_1038_npp_2011_319 crossref_primary_10_1016_j_neubiorev_2022_104877 crossref_primary_10_1111_acer_12361 crossref_primary_10_1038_s41380_023_02246_1 crossref_primary_10_1038_s41598_025_94188_7 crossref_primary_10_3109_15622975_2013_829585 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1177/0269881108091074 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Psychology Pharmacy, Therapeutics, & Pharmacology |
| ExternalDocumentID | 18562436 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCRR NIH HHS grantid: P20 RR017701 – fundername: NCRR NIH HHS grantid: RR017701 |
| GroupedDBID | --- -TM -~X .2E .2F .2G .2J .2N 01A 0R~ 1~K 29L 31R 31S 31U 31X 31Y 31Z 4.4 53G 54M 5GY 5VS 6PF 85S AABMB AABOD AACKU AACMV AACTG AADUE AAEJI AAEWN AAGGD AAGLT AAGMC AAJIQ AAJOX AAJPV AAKGS AANSI AAPEO AAPII AAQDB AAQXH AAQXI AARDL AARIX AATAA AATBZ AAUAS AAWTL AAXOT AAYTG AAZBJ ABAWC ABAWP ABCCA ABCJG ABDWY ABEIX ABFWQ ABHKI ABHQH ABIDT ABIVO ABJIS ABJNI ABJZC ABKRH ABLUO ABNCE ABPGX ABPNF ABQKF ABQXT ABRHV ABUJY ABVFX ABVVC ABYTW ACARO ACDSZ ACDXX ACFEJ ACFMA ACFYK ACGBL ACGFS ACGZU ACJER ACJTF ACLFY ACLHI ACLZU ACNXM ACOFE ACOXC ACPRK ACROE ACRPL ACSIQ ACUAV ACUIR ACXKE ACXMB ADBBV ADDLC ADEBD ADEIA ADMPF ADNBR ADNMO ADNON ADRRZ ADSTG ADTBJ ADUKL ADVBO ADYCS ADZYD ADZZY AECGH AECVZ AEDTQ AEKYL AENEX AEPTA AEQLS AERKM AESZF AEUHG AEWDL AEWHI AEXFG AEXNY AFEET AFKBI AFKRG AFMOU AFQAA AFRAH AFUIA AFVCE AFWMB AGHKR AGKLV AGNHF AGPXR AGQPQ AGWFA AGWNL AHDMH AHHFK AIGRN AJABX AJEFB AJGYC AJMMQ AJSCY AJUZI AJVBE AJXAJ AJXGE ALKWR ALMA_UNASSIGNED_HOLDINGS AMCVQ ANDLU ARTOV ASPBG AUTPY AUVAJ AVWKF AYAKG AZFZN B3H B8M B8O B8R B8Z B93 B94 BBRGL BDDNI BKIIM BKSCU BPACV BSEHC BWJAD BYIEH C45 CAG CBRKF CDWPY CFDXU CGR COF CORYS CQQTX CS3 CUTAK CUY CVF DB0 DC- DC0 DD- DD0 DE- DF0 DO- DOPDO DU5 DV7 DV9 D~Y EBS ECM EIF EJD EMOBN F5P FEDTE FHBDP GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION H13 HF~ HVGLF HZ~ IAO IEA IHR INH INR IVC J8X K.F K.J N9A NPM O9- OVD P.B P2P PQQKQ Q1R Q7K Q7L Q7R Q7U Q7X Q82 Q83 RIG ROL S01 SASJQ SAUOL SBI SCNPE SDB SFB SFC SFK SFT SGA SGO SGP SGR SGV SGX SGZ SHG SNB SPJ SPP SPQ SPV SQCSI STM TEORI UPT YQT ZONMY ZPPRI ZRKOI ZSSAH ZY4 7X8 AJHME |
| ID | FETCH-LOGICAL-c756t-a1f5619c9578519da60d3cfce3359166784b2369e1d3761d485b11b4ed7ac4352 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 26 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000266938800008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0269-8811 |
| IngestDate | Sun Sep 28 12:19:33 EDT 2025 Mon Jul 21 05:36:04 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c756t-a1f5619c9578519da60d3cfce3359166784b2369e1d3761d485b11b4ed7ac4352 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://cir.nii.ac.jp/crid/1872835442913216640 |
| PMID | 18562436 |
| PQID | 67388801 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_67388801 pubmed_primary_18562436 |
| PublicationCentury | 2000 |
| PublicationDate | 2009-07-01 |
| PublicationDateYYYYMMDD | 2009-07-01 |
| PublicationDate_xml | – month: 07 year: 2009 text: 2009-07-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of psychopharmacology (Oxford) |
| PublicationTitleAlternate | J Psychopharmacol |
| PublicationYear | 2009 |
| SSID | ssj0016465 |
| Score | 2.054421 |
| Snippet | Postmortem research has revealed that there is a lower density of glial cells in regions of the prefrontal cortex (PFC) of uncomplicated alcoholics when... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 550 |
| SubjectTerms | 2-Aminoadipic Acid - pharmacology Alcohol Drinking - psychology Animals Astrocytes - drug effects Astrocytes - metabolism Citrates - pharmacology Gap Junctions - drug effects Gap Junctions - metabolism Gliotoxin - pharmacology Glycyrrhetinic Acid - analogs & derivatives Glycyrrhetinic Acid - pharmacology Male Neuroglia - drug effects Neuroglia - metabolism Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Rats Rats, Wistar |
| Title | Infusion of gliotoxins or a gap junction blocker in the prelimbic cortex increases alcohol preference in Wistar rats |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/18562436 https://www.proquest.com/docview/67388801 |
| Volume | 23 |
| WOSCitedRecordID | wos000266938800008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT9tAEB4F0gMXoCmlaaHMAXFiRdZ2_JCQKoSI2gNRDqDmFu2ud5GB2sFOquTfM2MnzQn1wMWHlXdl7czOfN55fACnNuz53PBUaBkoEcTSF5qQhfC0cdpESknXkE1Ew2E8HiejFlyua2E4rXJtE2tDnRaG78gvmJ2SdE3-mL4I5ozi2OqKQGML2j4BGU7oisabGEIY1ESS9JORiDiWchOkvOAxHiK4lHBG4tvwsnYzg733feA-7K7gJV41-vARWjbvwNmo6U-9PMe7TblVdY5nONp0rl52YOefOVx-gtmv3M35Lg0Lhw-c2VEssrzCokSFD2qKj-QSWayoySE-2RKzHAlO4rS0z9kfnRk0nMm7oHGGppWtUDWEvPzKqs6QJ_1mDFsi6WJ1APeDm7vrn2LF0SBM1A9ngmRJCCwxCTfNkUmqwl7qG2es7_cJeZIrDLTnh4mVKZkymQZxX0upA5tGyhBU8z7Ddl7k9gugI-PgQo_8ZZ8wh3aJqZvtGVpU9UyaduFkvfETOgMc2FC5LebVZL31XThsZDeZNq06JoRGQi_ww6__nfsNdppAEWfiHkHb0em3x_DB_J1lVfm9Vi16Dke3r0dc2h8 |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Infusion+of+gliotoxins+or+a+gap+junction+blocker+in+the+prelimbic+cortex+increases+alcohol+preference+in+Wistar+rats&rft.jtitle=Journal+of+psychopharmacology+%28Oxford%29&rft.au=Miguel-Hidalgo%2C+J&rft.au=Shoyama%2C+Y&rft.au=Wanzo%2C+V&rft.date=2009-07-01&rft.issn=0269-8811&rft.volume=23&rft.issue=5&rft.spage=550&rft_id=info:doi/10.1177%2F0269881108091074&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0269-8811&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0269-8811&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0269-8811&client=summon |