Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia

Applying a new, more sensitive single-cell transcriptomics method to diagnosis, remission and progression samples from patients with chronic myeloid leukemia reveals insight into the heterogeneity of cells that resist treatment with targeted therapy, as well as into the dynamics of disease progressi...

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Bibliographic Details
Published in:	Nature medicine Vol. 23; no. 6; pp. 692 - 702
Main Authors:	Giustacchini, Alice, Thongjuea, Supat, Barkas, Nikolaos, Woll, Petter S, Povinelli, Benjamin J, Booth, Christopher A G, Sopp, Paul, Norfo, Ruggiero, Rodriguez-Meira, Alba, Ashley, Neil, Jamieson, Lauren, Vyas, Paresh, Anderson, Kristina, Segerstolpe, Åsa, Qian, Hong, Olsson-Strömberg, Ulla, Mustjoki, Satu, Sandberg, Rickard, Jacobsen, Sten Eirik W, Mead, Adam J
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.06.2017 Nature Publishing Group
Subjects:	38/39 38/91 45 45/100 631/337/2019 631/532/71 631/67/71 692/699/67/1990/283/1895 96/31 Adult Aged Analysis Biomedicine Blast Crisis - genetics Cancer Research Cancer therapies Chromatin Immunoprecipitation Chronic myeloid leukemia Core Binding Factor Alpha 2 Subunit - genetics Diagnosis Female Flow Cytometry Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Library Genes, abl - genetics Genetic aspects Health aspects Hematology Heterogeneity Hospitals Humans In Situ Hybridization, Fluorescence Infectious Diseases Kinases Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Male Medical research Medicine Metabolic Diseases Middle Aged Molecular Medicine Mutation Neoplastic Stem Cells - metabolism Neurosciences Remission (Medicine) Reverse Transcriptase Polymerase Chain Reaction RNA sequencing Sequence Analysis, DNA Sequence Analysis, RNA Single-Cell Analysis Stem cells Subpopulations Transcriptome Tumors Young Adult United Kingdom Sweden United Kingdom > UK
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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