Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

In multiple sclerosis and experimental autoimmune encephalomyelitis, astrocytes produce lactosylceramide, a glycolipid that promotes astrocyte and microglial activation and immune cell infiltration into the CNS. Astrocytes have complex roles in health and disease, thus it is important to study the p...

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Bibliographic Details
Published in:	Nature medicine Vol. 20; no. 10; pp. 1147 - 1156
Main Authors:	Mayo, Lior, Trauger, Sunia A, Blain, Manon, Nadeau, Meghan, Patel, Bonny, Alvarez, Jorge I, Mascanfroni, Ivan D, Yeste, Ada, Kivisäkk, Pia, Kallas, Keith, Ellezam, Benjamin, Bakshi, Rohit, Prat, Alexandre, Antel, Jack P, Weiner, Howard L, Quintana, Francisco J
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.10.2014 Nature Publishing Group
Subjects:	13/1 13/106 13/31 13/44 14/63 631/250/262 631/250/38 64/60 82/80 96/95 Analysis Animals Antigens, CD - metabolism Astrocytes Astrocytes - immunology Astrocytes - metabolism Autoimmune diseases Biomedicine Cancer Research Cellular biology Central nervous system Central Nervous System - immunology Central Nervous System - metabolism Central Nervous System - pathology Chemokine CCL2 - genetics Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Enzymes Female Galactosyltransferases - genetics Galactosyltransferases - metabolism Gene expression Gene Knockdown Techniques Glial Fibrillary Acidic Protein Glycolipids - metabolism Humans Immunity, Innate Infectious Diseases Inflammation Inflammatory diseases Lactosylceramides - metabolism Lesions Metabolic Diseases Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Transgenic Molecular Medicine Multiple Sclerosis - genetics Multiple Sclerosis - immunology Multiple Sclerosis - metabolism Nerve Degeneration - genetics Nerve Degeneration - immunology Nerve Degeneration - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nervous system Neurosciences Up-Regulation
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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