Distribution of macrophage polarization markers in human atherosclerosis

Macrophages are decisive in the chronic inflammatory processes that drive atherogenesis. The purpose of this study was to explore the presence and spatial distribution of polarized macrophage populations in human atherosclerosis. We used transcriptomics and immunohistochemistry to analyze macrophage...

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Bibliographic Details
Published in:	Atherosclerosis Vol. 225; no. 2; pp. 461 - 468
Main Authors:	Stöger, J. Lauran, Gijbels, Marion J.J., van der Velden, Saskia, Manca, Marco, van der Loos, Chris M., Biessen, Erik A.L., Daemen, Mat J.A.P., Lutgens, Esther, de Winther, Menno P.J.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ireland Ltd 01.12.2012 Elsevier
Subjects:	Adventitia Adventitia - immunology Adventitia - pathology Aged Aged, 80 and over analysis atherogenesis atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Biomarkers Biomarkers - analysis Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Cardiovascular system Carotid Arteries Carotid Arteries - immunology Carotid Arteries - pathology Carotid Artery Diseases Carotid Artery Diseases - genetics Carotid Artery Diseases - immunology Carotid Artery Diseases - pathology classification Coronary artery disease Disease Progression Female Fibrosis Foam cell Gene Expression Profiling Gene Expression Regulation genetics hemorrhage Human pathology Humans Immunohistochemistry immunology Inflammation Mediators Inflammation Mediators - analysis Innate immunity Macrophages Macrophages - classification Macrophages - immunology Macrophages - pathology Male Medical sciences pathology Pharmacology. Drug treatments Plaque, Atherosclerotic RNA, Messenger RNA, Messenger - analysis Rupture, Spontaneous Severity of Illness Index transcription (genetics) Transcriptome transcriptomics Vasodilator agents. Cerebral vasodilators Innate immunity Foam cell Macrophages Coronary artery disease Human pathology Human Cardiovascular disease Coronary heart disease Immunity Vascular disease Anatomic pathology Atherosclerosis Macrophage
ISSN:	0021-9150, 1879-1484, 1879-1484
Online Access:	Get full text
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