Research Progress in the Pathogenesis of Alzheimer's Disease

Objective: Alzheimer's disease (AD) is a kind of chronic degenerative disease of the central nervous system, characteristics of cognitive dysfunction, and behavioral disability. The pathological changes include the formation of senile plaques-containing beta-amyloid (Aβ), neurofibrillary tangle...

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Published in:Chinese medical journal Vol. 131; no. 13; pp. 1618 - 1624
Main Author: Chen, Yi-Gang
Format: Journal Article
Language:English
Published: China Wolters Kluwer India Pvt. Ltd 05.07.2018
Medknow Publications and Media Pvt. Ltd
Lippincott Williams & Wilkins Ovid Technologies
Department of Physiology and Pathophysiology, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei 430081, China
Medknow Publications & Media Pvt Ltd
Wolters Kluwer
Subjects:
Alzheimer Disease - etiology
Alzheimer Disease - pathology
Alzheimer's disease
Alzheimer's Disease; Beta-Amyloid; Neurofibrillary Tangles; Pathogenesis
Amyloid beta-Peptides
Apoptosis
Autophagy
Brain - pathology
Brain research
Cellular signal transduction
Endoplasmic reticulum
Enzymes
Gene mutation
Genes
Genetic aspects
Humans
Kinases
Neurodegeneration
Neurofibrillary Tangles
Neurons - pathology
Pathogenesis
Pathology
Phosphorylation
Physiological aspects
Proteins
Review
Sedimentation & deposition
Synapses
Synapses - pathology
tau Proteins
Beta-Amyloid
Alzheimer's Disease
Pathogenesis
Neurofibrillary Tangles
ISSN:0366-6999, 2542-5641, 2542-5641
Online Access:Get full text
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Summary:Objective: Alzheimer's disease (AD) is a kind of chronic degenerative disease of the central nervous system, characteristics of cognitive dysfunction, and behavioral disability. The pathological changes include the formation of senile plaques-containing beta-amyloid (Aβ), neurofibrillary tangles (NFTs), loss of neurons, and synapses. So far, the pathogenesis of AD is still unclear. This study was aimed to review the major pathogenesis of AD-related to the published AD studies in recent 20 years. Data Sources: The author retrieved information from the PubMed database up to January 2018, using various search terms and their combinations, including AD, Aβ, NFTs, pathogenesis, and genetic mutation. Study Selection: The author included data from peer-reviewed journals printed in English and Chinese on pathophysiological factors in AD. He organized these informations to explain the possible pathogenesis in AD. Results: There are many amounts of data supporting the view that AD pathogenesis so far there mainly are Aβ toxicity, tau protein, gene mutation, synaptic damages, intermediate neurons and network abnormalities, changes in mitochondrial function, chemokines, etc., Its nosogenesis may be involved in multiple theories and involved in multiple molecular signaling pathways, including Aβ, tau protein, and synaptic anomaly; mutual relationship between the mechanisms urge jointly neuronal degeneration. Conclusions: This review highlights the research advances in the pathogenesis of AD. Future research has needed to fully disclose the association between multiple pathogenesis at the same time to interdict multiple signaling pathways, etc.
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ISSN:0366-6999
2542-5641
2542-5641
DOI:10.4103/0366-6999.235112