Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling

Background The Amoebozoa constitute one of the primary divisions of eukaryotes, encompassing taxa of both biomedical and evolutionary importance, yet its genomic diversity remains largely unsampled. Here we present an analysis of a whole genome assembly of Acanthamoeba castellanii ( Ac ) the first r...

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Vydané v:Genome biology Ročník 14; číslo 2; s. R11
Hlavní autori: Clarke, Michael, Lohan, Amanda J, Liu, Bernard, Lagkouvardos, Ilias, Roy, Scott, Zafar, Nikhat, Bertelli, Claire, Schilde, Christina, Kianianmomeni, Arash, Bürglin, Thomas R, Frech, Christian, Turcotte, Bernard, Kopec, Klaus O, Synnott, John M, Choo, Caleb, Paponov, Ivan, Finkler, Aliza, Heng Tan, Chris Soon, Hutchins, Andrew P, Weinmeier, Thomas, Rattei, Thomas, Chu, Jeffery SC, Gimenez, Gregory, Irimia, Manuel, Rigden, Daniel J, Fitzpatrick, David A, Lorenzo-Morales, Jacob, Bateman, Alex, Chiu, Cheng-Hsun, Tang, Petrus, Hegemann, Peter, Fromm, Hillel, Raoult, Didier, Greub, Gilbert, Miranda-Saavedra, Diego, Chen, Nansheng, Nash, Piers, Ginger, Michael L, Horn, Matthias, Schaap, Pauline, Caler, Lis, Loftus, Brendan J
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 01.02.2013
Predmet:
Acanthamoeba castellanii
Acanthamoeba castellanii - genetics
Amoebozoa
Animal Genetics and Genomics
Animalia
bacteria
Bioinformatics
Biomedical and Life Sciences
cell communication
eukaryotic cells
evolution
Evolution, Molecular
Evolutionary Biology
Gene Transfer, Horizontal
genes
genetic variation
genome assembly
Genome, Protozoan
genomics
horizontal gene transfer
Human Genetics
immune system
Introns
Life Sciences
Metazoa
Microbial Genetics and Genomics
Plant Genetics and Genomics
Protein-Tyrosine Kinases - genetics
Protein-Tyrosine Kinases - metabolism
Protozoan Proteins - genetics
Protozoan Proteins - metabolism
receptors
Signal Transduction
transcription (genetics)
viruses
Mannose Binding Protein
Acanthamoeba Castellanii
Lateral Gene Transfer
Tyrosine Kinase Signaling
Intron Gain
ISSN:1474-760X, 1465-6906, 1474-760X, 1465-6914
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Shrnutí:Background The Amoebozoa constitute one of the primary divisions of eukaryotes, encompassing taxa of both biomedical and evolutionary importance, yet its genomic diversity remains largely unsampled. Here we present an analysis of a whole genome assembly of Acanthamoeba castellanii ( Ac ) the first representative from a solitary free-living amoebozoan. Results Ac encodes 15,455 compact intron-rich genes, a significant number of which are predicted to have arisen through inter-kingdom lateral gene transfer (LGT). A majority of the LGT candidates have undergone a substantial degree of intronization and Ac appears to have incorporated them into established transcriptional programs. Ac manifests a complex signaling and cell communication repertoire, including a complete tyrosine kinase signaling toolkit and a comparable diversity of predicted extracellular receptors to that found in the facultatively multicellular dictyostelids. An important environmental host of a diverse range of bacteria and viruses, Ac utilizes a diverse repertoire of predicted pattern recognition receptors, many with predicted orthologous functions in the innate immune systems of higher organisms. Conclusions Our analysis highlights the important role of LGT in the biology of Ac and in the diversification of microbial eukaryotes. The early evolution of a key signaling facility implicated in the evolution of metazoan multicellularity strongly argues for its emergence early in the Unikont lineage. Overall, the availability of an Ac genome should aid in deciphering the biology of the Amoebozoa and facilitate functional genomic studies in this important model organism and environmental host.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1474-760X
1465-6906
1474-760X
1465-6914
DOI:10.1186/gb-2013-14-2-r11