Neuronal enhancers are hotspots for DNA single-strand break repair

Defects in DNA repair frequently lead to neurodevelopmental and neurodegenerative diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic neurons 1 , 2 . The cellular genome is subjected to a constant barrage of endogenous DNA damage, but surprisingly little is know...

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Veröffentlicht in:	Nature (London) Jg. 593; H. 7859; S. 440 - 444
Hauptverfasser:	Wu, Wei, Kargbo-Hill, Sarah E., Nathan, William J., Paiano, Jacob, Callen, Elsa, Wang, Dongpeng, Shinoda, Kenta, van Wietmarschen, Niek, Colón-Mercado, Jennifer M., Zong, Dali, De Pace, Raffaella, Shih, Han-Yu, Coon, Steve, Parsadanian, Maia, Pavani, Raphael, Hanzlikova, Hana, Park, Solji, Jung, Seol Kyoung, McHugh, Peter J., Canela, Andres, Chen, Chongyi, Casellas, Rafael, Caldecott, Keith W., Ward, Michael E., Nussenzweig, André
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 20.05.2021 Nature Publishing Group
Schlagworte:	45 45/1 45/15 45/22 45/23 45/71 45/77 45/88 45/90 49/15 5-Methylcytosine - metabolism 631/337/1427/2123 631/378/340 Cell Line CpG islands Defects Demethylation Deoxyribonucleic acid DNA DNA - biosynthesis DNA Breaks, Single-Stranded DNA damage DNA methylation DNA Repair DNA Replication Enhancer Elements, Genetic - genetics Gene mapping Genes Genetic aspects Genetic research Genomes Humanities and Social Sciences Humans Incorporation Labeling Male Methylation multidisciplinary Neurodegenerative diseases Neurodevelopmental disorders Neurons Neurons - metabolism Phenotypes Physiological aspects Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerases - metabolism Repair Science Science (multidisciplinary) Sequence Analysis, DNA Synthesis XRCC1 protein United States
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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