Layer-specific activation in human primary somatosensory cortex during tactile temporal prediction error processing

The human brain continuously generates predictions of incoming sensory input and calculates corresponding prediction errors from the perceived inputs to update internal predictions. In human primary somatosensory cortex (area 3b), different cortical layers are involved in receiving the sensory input...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Jg. 248; S. 118867
Hauptverfasser: Yu, Yinghua, Huber, Laurentius, Yang, Jiajia, Fukunaga, Masaki, Chai, Yuhui, Jangraw, David C., Chen, Gang, Handwerker, Daniel A., Molfese, Peter J., Ejima, Yoshimichi, Sadato, Norihiro, Wu, Jinglong, Bandettini, Peter A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier Inc 01.03.2022
Elsevier Limited
Elsevier
Schlagworte:
Adult
Brain Mapping
Cortex (somatosensory)
Cortex (temporal)
Feedback
Female
Fingers - physiology
Functional magnetic resonance imaging
Healthy Volunteers
High-resolution CBV–fMRI
Humans
Image Processing, Computer-Assisted
Information processing
Layer-specific fMRI
Magnetic Resonance Imaging - methods
Male
Neuroimaging
Physiology
Predictions
Primary somatosensory cortex
Reproducibility of Results
Sensitivity and Specificity
Somatosensory Cortex - physiology
Tactile prediction
Temporal prediction error
Time Perception
Time series
Touch - physiology
United States > US
Tactile prediction
Temporal prediction error
Layer-specific fMRI
Primary somatosensory cortex
High-resolution CBV–fMRI
ISSN:1053-8119, 1095-9572, 1095-9572
Online-Zugang:Volltext
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Zusammenfassung:The human brain continuously generates predictions of incoming sensory input and calculates corresponding prediction errors from the perceived inputs to update internal predictions. In human primary somatosensory cortex (area 3b), different cortical layers are involved in receiving the sensory input and generation of error signals. It remains unknown, however, how the layers in the human area 3b contribute to the temporal prediction error processing. To investigate prediction error representation in the area 3b across layers, we acquired layer-specific functional magnetic resonance imaging (fMRI) data at 7T from human area 3b during a task of index finger poking with no-delay, short-delay and long-delay touching sequences. We demonstrate that all three tasks increased activity in both superficial and deep layers of area 3b compared to the random sensory input. The fMRI signal was differentially modulated solely in the deep layers rather than the superficial layers of area 3b by the delay time. Compared with the no-delay stimuli, activity was greater in the deep layers of area 3b during the short-delay stimuli but lower during the long-delay stimuli. This difference activity features in the superficial and deep layers suggest distinct functional contributions of area 3b layers to tactile temporal prediction error processing. The functional segregation in area 3b across layers may reflect that the excitatory and inhibitory interplay in the sensory cortex contributions to flexible communication between cortical layers or between cortical areas. [Display omitted]
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1053-8119
1095-9572
1095-9572
DOI:10.1016/j.neuroimage.2021.118867