MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs

Prompt coronary catheterization and revascularization have markedly improved the outcomes of myocardial infarction, but have also resulted in a growing number of surviving patients with permanent structural damage of the heart, which frequently leads to heart failure. There is an unmet clinical need...

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Bibliographic Details
Published in:	Nature (London) Vol. 569; no. 7756; pp. 418 - 422
Main Authors:	Gabisonia, Khatia, Prosdocimo, Giulia, Aquaro, Giovanni Donato, Carlucci, Lucia, Zentilin, Lorena, Secco, Ilaria, Ali, Hashim, Braga, Luca, Gorgodze, Nikoloz, Bernini, Fabio, Burchielli, Silvia, Collesi, Chiara, Zandonà, Lorenzo, Sinagra, Gianfranco, Piacenti, Marcello, Zacchigna, Serena, Bussani, Rossana, Recchia, Fabio A., Giacca, Mauro
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.05.2019 Nature Publishing Group
Subjects:	13/1 13/2 13/44 13/89 14/19 38 38/71 38/89 42/44 631/337/384/331 631/61 64 Animals Cardiac function Cardiomyocytes Care and treatment Catheterization Cell cycle Cell Proliferation - genetics Congestive heart failure Control Death, Sudden, Cardiac - etiology Gene therapy Genetic aspects Health aspects Heart Heart - physiology Heart - physiopathology Heart attack Heart attacks Heart failure Hogs Humanities and Social Sciences Infiltration Kinases Letter Male Methods MicroRNA MicroRNAs MicroRNAs - administration & dosage MicroRNAs - adverse effects MicroRNAs - genetics MicroRNAs - therapeutic use miRNA Mitral valve repair Morphology multidisciplinary Muscle contraction Muscles Musculoskeletal system Myocardial infarction Myocardial Infarction - genetics Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - therapy Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism NMR Nuclear magnetic resonance Phenotypes Regeneration - genetics Repair Ribonucleic acid RNA Science Science (multidisciplinary) Structural damage Suidae Sus scrofa - genetics Swine Therapy
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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