Somatic mutations and clonal dynamics in healthy and cirrhotic human liver

The most common causes of chronic liver disease are excess alcohol intake, viral hepatitis and non-alcoholic fatty liver disease, with the clinical spectrum ranging in severity from hepatic inflammation to cirrhosis, liver failure or hepatocellular carcinoma (HCC). The genome of HCC exhibits diverse...

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Bibliographic Details
Published in:	Nature (London) Vol. 574; no. 7779; pp. 538 - 542
Main Authors:	Brunner, Simon F., Roberts, Nicola D., Wylie, Luke A., Moore, Luiza, Aitken, Sarah J., Davies, Susan E., Sanders, Mathijs A., Ellis, Pete, Alder, Chris, Hooks, Yvette, Abascal, Federico, Stratton, Michael R., Martincorena, Inigo, Hoare, Matthew, Campbell, Peter J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.10.2019 Nature Publishing Group
Subjects:	45 45/23 631/208/737 631/67/69 692/308/2056 Alcohol Bioinformatics Cancer Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell division Cirrhosis Clone Cells - cytology Clone Cells - metabolism Clone Cells - pathology Cloning Confidence intervals DNA Mutational Analysis Fatty liver Fibrosis Fibrosis - genetics Fibrosis - pathology Gene expression Gene sequencing Genetic aspects Genetic transformation Genomes Hepatitis Hepatocellular carcinoma Hepatocytes Hepatocytes - cytology Hepatocytes - metabolism Hepatocytes - pathology Hepatology Humanities and Social Sciences Humans Hypothesis testing Liver Liver - cytology Liver - metabolism Liver - pathology Liver cancer Liver cirrhosis Liver diseases Liver failure Male Middle Aged multidisciplinary Mutation Mutation (Biology) Nodules Patients Phylogeny Physiological aspects Regeneration Science Science (multidisciplinary) Signatures Stem cells Stem Cells - cytology Stem Cells - metabolism Stem Cells - pathology Toxicity United Kingdom
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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