MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma

Background A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a four microRNA (miRNA) signature that is prognostic for DM. In this study, charac...

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Bibliographic Details
Published in:	BMC cancer Vol. 20; no. 1; pp. 597 - 13
Main Authors:	Bissey, Pierre-Antoine, Teng, Mona, Law, Jacqueline H., Shi, Wei, Bruce, Jeff P., Petit, Valentin, Tsao, Sai W., Yip, Kenneth W., Liu, Fei-Fei
Format:	Journal Article
Language:	English
Published:	London BioMed Central 26.06.2020 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Antineoplastic agents Benzamides - pharmacology Biomedical and Life Sciences Biomedicine Biopsy Cancer metastasis Cancer Research Carcinoma Cell and molecular biology Cell cycle Cell Line, Tumor Cell viability Chemoradiotherapy Chemoresistance Chemotherapy Cisplatin Cisplatin - pharmacology Cisplatin - therapeutic use Dioxoles - pharmacology Down-Regulation Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics E-cadherin EMT Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation, Neoplastic - drug effects Growth factors Health Promotion and Disease Prevention Humans Immunohistochemistry Lymphocytes Medicine/Public Health Mesenchyme Metastases Metastasis MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miR-34c miRNA Nasopharyngeal cancer Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - drug therapy Nasopharyngeal Carcinoma - genetics Nasopharyngeal Carcinoma - mortality Nasopharyngeal Carcinoma - pathology Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - mortality Nasopharyngeal Neoplasms - pathology Nasopharynx - pathology Oncology Overexpression Patients Prostate Radiation therapy Research Article RNA-Seq SOX4 SOXC Transcription Factors - genetics Stem cells Surgical Oncology TGFβ1 Throat cancer Transforming Growth Factor beta1 - antagonists & inhibitors Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 Transforming growth factors France United States > US TGFβ1 Nasopharyngeal cancer EMT SOX4 Cisplatin miR-34c
ISSN:	1471-2407, 1471-2407
Online Access:	Get full text
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