A Genomic-Systems Biology Map for Cardiovascular Function

With the draft sequence of the human genome available, there is a need to better define gene function in the context of systems biology. We studied 239 cardiovascular and renal phenotypes in 113 male rats derived from an F2intercross and mapped 81 of these traits onto the genome. Aggregates of trait...

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Vydáno v:	Science (American Association for the Advancement of Science) Ročník 294; číslo 5547; s. 1723 - 1726
Hlavní autoři:	Stoll, Monika, Cowley, Allen W., Tonellato, Peter J., Greene, Andrew S., Kaldunski, Mary L., Roman, Richard J., Dumas, Pierre, Schork, Nicholas J., Wang, Zhitao, Jacob, Howard J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Washington, DC American Society for the Advancement of Science 23.11.2001 American Association for the Advancement of Science The American Association for the Advancement of Science
Témata:	Alleles Animals Biological and medical sciences Blood pressure Blood Pressure - drug effects Blood Pressure - genetics Cardiovascular diseases cardiovascular function Cardiovascular Physiological Phenomena - drug effects Cardiovascular system Chromosome 1 chromosome 18 chromosome 2 chromosome 7 Chromosome Mapping - methods Chromosomes Chromosomes - genetics Correlation Crosses, Genetic Female Fundamental and applied biological sciences. Psychology Genes Genetic aspects Genetic mapping Genomes Genomics Genomics - methods Genotypes Humans Hypertension Kidney - physiology Lod Score Male Males Molecular and cellular biology Nitric Oxide Synthase - genetics Norepinephrine Norepinephrine - pharmacology Phenotype Phenotypes Phenotypic traits Profiles Quantitative Trait, Heritable Rats Rodents Vasodilation - genetics
ISSN:	0036-8075, 1095-9203
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Shrnutí:	With the draft sequence of the human genome available, there is a need to better define gene function in the context of systems biology. We studied 239 cardiovascular and renal phenotypes in 113 male rats derived from an F2intercross and mapped 81 of these traits onto the genome. Aggregates of traits were identified on chromosomes 1, 2, 7, and 18. Systems biology was assessed by examining patterns of correlations ("physiological profiles") that can be used for gene hunting, mechanism-based physiological studies, and, with comparative genomics, translating these data to the human genome.
Bibliografie:	SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-2 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1062117