A Genomic-Systems Biology Map for Cardiovascular Function

With the draft sequence of the human genome available, there is a need to better define gene function in the context of systems biology. We studied 239 cardiovascular and renal phenotypes in 113 male rats derived from an F2intercross and mapped 81 of these traits onto the genome. Aggregates of trait...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) Vol. 294; no. 5547; pp. 1723 - 1726
Main Authors: Stoll, Monika, Cowley, Allen W., Tonellato, Peter J., Greene, Andrew S., Kaldunski, Mary L., Roman, Richard J., Dumas, Pierre, Schork, Nicholas J., Wang, Zhitao, Jacob, Howard J.
Format: Journal Article
Language:English
Published: Washington, DC American Society for the Advancement of Science 23.11.2001
American Association for the Advancement of Science
The American Association for the Advancement of Science
Subjects:
Alleles
Animals
Biological and medical sciences
Blood pressure
Blood Pressure - drug effects
Blood Pressure - genetics
Cardiovascular diseases
cardiovascular function
Cardiovascular Physiological Phenomena - drug effects
Cardiovascular system
Chromosome 1
chromosome 18
chromosome 2
chromosome 7
Chromosome Mapping - methods
Chromosomes
Chromosomes - genetics
Correlation
Crosses, Genetic
Female
Fundamental and applied biological sciences. Psychology
Genes
Genetic aspects
Genetic mapping
Genomes
Genomics
Genomics - methods
Genotypes
Humans
Hypertension
Kidney - physiology
Lod Score
Male
Males
Molecular and cellular biology
Nitric Oxide Synthase - genetics
Norepinephrine
Norepinephrine - pharmacology
Phenotype
Phenotypes
Phenotypic traits
Profiles
Quantitative Trait, Heritable
Rats
Rodents
Vasodilation - genetics
ISSN:0036-8075, 1095-9203
Online Access:Get full text
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Description
Summary:With the draft sequence of the human genome available, there is a need to better define gene function in the context of systems biology. We studied 239 cardiovascular and renal phenotypes in 113 male rats derived from an F2intercross and mapped 81 of these traits onto the genome. Aggregates of traits were identified on chromosomes 1, 2, 7, and 18. Systems biology was assessed by examining patterns of correlations ("physiological profiles") that can be used for gene hunting, mechanism-based physiological studies, and, with comparative genomics, translating these data to the human genome.
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.1062117