Association between Regimen Composition and Treatment Response in Patients with Multidrug-Resistant Tuberculosis: A Prospective Cohort Study

For treating multidrug-resistant tuberculosis (MDR TB), the World Health Organization (WHO) recommends a regimen of at least four second-line drugs that are likely to be effective as well as pyrazinamide. WHO guidelines indicate only marginal benefit for regimens based directly on drug susceptibilit...

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Bibliographic Details
Published in:	PLoS medicine Vol. 12; no. 12; p. e1001932
Main Authors:	Yuen, Courtney M., Kurbatova, Ekaterina V., Tupasi, Thelma, Caoili, Janice Campos, Van Der Walt, Martie, Kvasnovsky, Charlotte, Yagui, Martin, Bayona, Jaime, Contreras, Carmen, Leimane, Vaira, Ershova, Julia, Via, Laura E., Kim, HeeJin, Akksilp, Somsak, Kazennyy, Boris Y., Volchenkov, Grigory V., Jou, Ruwen, Kliiman, Kai, Demikhova, Olga V., Vasilyeva, Irina A., Dalton, Tracy, Cegielski, J. Peter
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.12.2015 Public Library of Science (PLoS)
Subjects:	Adolescent Adult Aged Aged, 80 and over Antibiotics Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Care and treatment Clinical Protocols Clinical trials Cohort Studies Drug resistance Drug Therapy, Combination - statistics & numerical data Global Health Humans Microbial Sensitivity Tests Middle Aged Multidrug resistant organisms Mycobacterium - drug effects Proportional Hazards Models Prospective Studies Sputum - microbiology Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Young Adult
ISSN:	1549-1676, 1549-1277, 1549-1676
Online Access:	Get full text
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