Shed GP of Ebola Virus Triggers Immune Activation and Increased Vascular Permeability

During Ebola virus (EBOV) infection a significant amount of surface glycoprotein GP is shed from infected cells in a soluble form due to cleavage by cellular metalloprotease TACE. Shed GP and non-structural secreted glycoprotein sGP, both expressed from the same GP gene, have been detected in the bl...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 10; no. 11; p. e1004509
Main Authors:	Escudero-Pérez, Beatriz, Volchkova, Valentina A., Dolnik, Olga, Lawrence, Philip, Volchkov, Viktor E.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.11.2014 Public Library of Science (PLoS)
Subjects:	Animals Antigens, CD - immunology Bacteriology Biology and Life Sciences Cytokines Cytokines - immunology Dendritic Cells - immunology Dendritic Cells - pathology Dendritic Cells - virology Ebola virus Ebolavirus - immunology Experiments Flow cytometry Guinea Pigs Health aspects Hemorrhagic Fever, Ebola - immunology Host-virus relationships Human Umbilical Vein Endothelial Cells - immunology Human Umbilical Vein Endothelial Cells - pathology Human Umbilical Vein Endothelial Cells - virology Humans Immune response Immune system Immunological research Immunology Infections Life Sciences Lymphocytes Macrophages - immunology Macrophages - pathology Macrophages - virology Medicine and Health Sciences Membrane Glycoproteins - immunology Microbiology and Parasitology Mortality Permeability Statistical analysis Toll-Like Receptor 4 - immunology Viral infections Viral Proteins - immunology Virology Virus research Human Umbilical Vein Endothelial Cells Ebolavirus Antigens CD Hemorrhagic Fever Dendritic Cells Guinea Pigs Toll-Like Receptor 4 Cytokines Humans Viral Proteins Macrophages Animals Membrane Glycoproteins Ebola
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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