myofibroblast, a key cell in normal and pathological tissue repair

Myofibroblasts are characterized by their expression of α-smooth muscle actin, their enhanced contractility when compared to normal fibroblasts and their increased synthetic activity of extracellular matrix proteins. Myofibroblasts play an important role in normal tissue repair processes, particular...

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Podrobná bibliografie
Vydáno v:	Cellular and molecular life sciences : CMLS Ročník 73; číslo 6; s. 1145 - 1157
Hlavní autoři:	Darby, Ian A, Zakuan, Noraina, Billet, Fabrice, Desmoulière, Alexis
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Cham Springer International Publishing 01.03.2016 Springer Nature B.V Springer Verlag
Témata:	Actin Animals Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Cancer Cell Biology Cellular biology Cicatrix - metabolism Cicatrix - pathology Extracellular matrix fibroblasts Fibrosis Humans kidneys Life Sciences liver Muscle contraction muscles Myofibroblasts - cytology Myofibroblasts - metabolism Myofibroblasts - pathology Neoplasms - metabolism Neoplasms - pathology Pathology Protein expression Review Smooth muscle tissue repair Wound Healing Innervation Contractility Excessive scarring Fibrosis Extracellular matrix Cancer stroma α-Smooth muscle actin alpha-Smooth muscle actin
ISSN:	1420-682X, 1420-9071, 1420-9071
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Myofibroblasts are characterized by their expression of α-smooth muscle actin, their enhanced contractility when compared to normal fibroblasts and their increased synthetic activity of extracellular matrix proteins. Myofibroblasts play an important role in normal tissue repair processes, particularly in the skin where they were first described. During normal tissue repair, they appear transiently and are then lost via apoptosis. However, the chronic presence and continued activity of myofibroblasts characterize many fibrotic pathologies, in the skin and internal organs including the liver, kidney and lung. More recently, it has become clear that myofibroblasts also play a role in many types of cancer as stromal or cancer-associated myofibroblast. The fact that myofibroblasts are now known to be key players in many pathologies makes understanding their functions, origin and the regulation of their differentiation important to enable them to be regulated in normal physiology and targeted in fibrosis, scarring and cancer.
Bibliografie:	http://dx.doi.org/10.1007/s00018-015-2110-0 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1420-682X 1420-9071 1420-9071
DOI:	10.1007/s00018-015-2110-0