Investigation of correlates of protection against pharyngeal carriage of Neisseria meningitidis genogroups W and Y in the African meningitis belt

Serum bactericidal antibody titres that correlate with protection against invasive meningococcal disease have been characterised. However, titres that are associated with protection against acquisition of pharyngeal carriage of Neisseria meningitidis are not known. Sera were obtained from the member...

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Published in:PloS one Vol. 12; no. 8; p. e0182575
Main Authors: Cooper, Laura V., Boukary, Rahamatou Moustapha, Aseffa, Abraham, Mihret, Wude, Collard, Jean-Marc, Daugla, Doumagoum, Hodgson, Abraham, Sokhna, Cheikh, Omotara, Babatunji, Sow, Samba, Quaye, Stephen Laryea, Diallo, Kanny, Manigart, Olivier, Maiden, Martin C. J., Findlow, Helen, Borrow, Ray, Stuart, James M., Greenwood, Brian M., Trotter, Caroline L.
Format: Journal Article
Language:English
Published: United States Public Library of Science 10.08.2017
Public Library of Science (PLoS)
Subjects:
Antibodies, Bacterial
Antibodies, Bacterial - blood
Bacteria
Bacterial meningitis
Bacteriology
Biology and Life Sciences
Carrier State
Carriers
Causes of
Consortia
Cross-Sectional Studies
Development and progression
Endemic Diseases
Epidemics
Female
Health surveillance
Households
Human health and pathology
Humans
Hygiene
Infections
Infectious diseases
Invasive meningococcal disease
Life Sciences
Male
Medical research
Medicine and Health Sciences
Meningitis
Meningitis, Meningococcal
Meningitis, Meningococcal - epidemiology
Meningitis, Meningococcal - immunology
Meningitis, Meningococcal - microbiology
Meningitis, Meningococcal - prevention & control
Meningococcal disease
Microbiology and Parasitology
Neisseria
Neisseria meningitidis
Neisseria meningitidis, Serogroup W-135
Neisseria meningitidis, Serogroup W-135 - immunology
Neisseria meningitidis, Serogroup Y
Neisseria meningitidis, Serogroup Y - immunology
Pharynx
Pharynx - microbiology
Physiological aspects
Protective Factors
Public health
Risk Factors
Santé publique et épidémiologie
Studies
Vaccination
Vaccines
Veterinary medicine
Young Adult
United Kingdom
Nigeria
Ethiopia
Addis Ababa Ethiopia
ISSN:1932-6203, 1932-6203
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Summary:Serum bactericidal antibody titres that correlate with protection against invasive meningococcal disease have been characterised. However, titres that are associated with protection against acquisition of pharyngeal carriage of Neisseria meningitidis are not known. Sera were obtained from the members of a household in seven countries of the African meningitis belt in which a pharyngeal carrier of N. meningitidis had been identified during a cross-sectional survey. Serum bactericidal antibody titres at baseline were compared between individuals in the household of the carrier who became a carrier of a meningococcus of the same genogroup during six months of subsequent follow-up and household members who did not become a carrier of a meningococcus of this genogroup during this period. Serum bacterial antibody titres were significantly higher in carriers of a serogroup W or Y meningococcus at the time of recruitment than in those who were not a carrier of N. meningitidis of the same genogroup. Serum bactericidal antibody titres to a strain of N. meningitis of the same genogroup as the index cases were no different in individuals who acquired carriage with a meningococcus of the same genogroup as the index case than in those who did not become a carrier during six months of follow-up. Serum bacterial antibody titres to N. meningitidis of genogroup W or Y in the range of those acquired by natural exposure to meningococci of these genogroups, or with cross-reactive bacteria, are not associated with protection against acquisition of carriage with meningococci of either of these genogroups.
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PMCID: PMC5552120
Competing Interests: RB and HF report performing contract research on behalf of Public Health England for Pfizer, Sanofi Pasteur, Serum Institute of India, and GSK. CLT and OM report receiving a consulting payment from GSK. All other authors report no potential conflicts. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
These authors are joint first authors on this work.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0182575