Detecting T cell receptors involved in immune responses from single repertoire snapshots

Hypervariable T cell receptors (TCRs) play a key role in adaptive immunity, recognizing a vast diversity of pathogen-derived antigens. Our ability to extract clinically relevant information from large high-throughput sequencing of TCR repertoires (RepSeq) data is limited, because little is known abo...

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Bibliographic Details
Published in:	PLoS biology Vol. 17; no. 6; p. e3000314
Main Authors:	Pogorelyy, Mikhail V., Minervina, Anastasia A., Shugay, Mikhail, Chudakov, Dmitriy M., Lebedev, Yuri B., Mora, Thierry, Walczak, Aleksandra M.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 13.06.2019 Public Library of Science (PLoS)
Subjects:	Adaptive immunity Adaptive Immunity - genetics Adaptive immunology Amino acids Ankylosing spondylitis Antigen receptors, T cell Antigens Antigens, Viral Arthritis Autoimmune diseases Biology and Life Sciences Cancer immunotherapy Cluster Analysis Clustering Complementarity Determining Regions - genetics Complementarity Determining Regions - physiology Data collection Disease control Funding High-Throughput Nucleotide Sequencing - methods Humans Immune response Immunity Immunology Immunotherapy Information processing Life Sciences Lymphocytes Lymphocytes T Medical research Medicine and Health Sciences Next-generation sequencing Observations Physiological aspects Receptors Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Receptors, Antigen, T-Cell - physiology Research and Analysis Methods Sequence Analysis, DNA - methods Software Spondylitis Supervision T cell receptors T cells T-cell receptor Vaccines Vector-borne diseases Yellow fever United States Czech Republic France United States > US Russia Immune response Lymphocytes Protein sequencing T cell receptors Nucleotide sequencing Cancer immunotherapy Sequence motif analysis Vaccination and immunization
ISSN:	1545-7885, 1544-9173, 1545-7885
Online Access:	Get full text
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