A ML29 reassortant virus protects guinea pigs against a distantly related Nigerian strain of Lassa virus and can provide sterilizing immunity

Lassa virus (LASV) is responsible for the deaths of thousands of people in West Africa annually. Genetic diversity among LASV strains is the highest among the Arenaviridae and represents a great challenge for vaccine development. Guinea pigs vaccinated with a ML29 reassortant vaccine experienced ste...

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Bibliographic Details
Published in:	Vaccine Vol. 25; no. 20; pp. 4093 - 4102
Main Authors:	Carrion, Ricardo, Patterson, Jean L., Johnson, Curtis, Gonzales, Monica, Moreira, Carmen R., Ticer, Anysha, Brasky, Kathleen, Hubbard, Gene B., Moshkoff, Dmitry, Zapata, Juan, Salvato, Maria S., Lukashevich, Igor S.
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 16.05.2007 Elsevier Elsevier Limited
Subjects:	Allergy and Immunology Animals Antibody Formation - immunology Applied microbiology Arenaviridae Biological and medical sciences Biomedical research Cloning Cross-protection Disease Experiments Fatalities Female Fundamental and applied biological sciences. Psychology Genetic diversity Genomes Guinea Pigs Hemorrhage Human viral diseases Immunity, Cellular - immunology Infections Infectious diseases Laboratories Lassa fever Lassa Fever - immunology Lassa Fever - pathology Lassa Fever - prevention & control Lassa Fever - virology Lassa fever and arenovirus diseases Lassa virus Lassa virus - immunology Lassa virus - isolation & purification Medical sciences Microbiology Miscellaneous Nigeria Proteins Reassortant vaccine Reassortant Viruses - genetics Reassortant Viruses - immunology RNA polymerase Sterilizing immunity Tropical viral diseases Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral diseases Viral Vaccines - immunology Viral Vaccines - pharmacology Virology Viruses Nigeria Guinea Sierra Leone Lassa fever Cross-protection Reassortant vaccine Sterilizing immunity Hemorrhagic fever Genetic reassortment Cross protection Rodentia Vaccine Lassa virus Arenavirus Strain Infection Virus Vertebrata Mammalia Guinea pig Viral disease Arbovirus disease Arenaviridae
ISSN:	0264-410X, 1873-2518
Online Access:	Get full text
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