Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension

Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%-2% of the population variation in BP and hypertension. This suggests the existence of more undiscovered common variants. We conduc...

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Vydané v:	PLoS genetics Ročník 6; číslo 10; s. e1001177
Hlavní autori:	Padmanabhan, Sandosh, Melander, Olle, Johnson, Toby, Di Blasio, Anna Maria, Lee, Wai K., Gentilini, Davide, Hastie, Claire E., Menni, Cristina, Monti, Maria Cristina, Delles, Christian, Laing, Stewart, Corso, Barbara, Navis, Gerjan, Kwakernaak, Arjan J., van der Harst, Pim, Bochud, Murielle, Maillard, Marc, Burnier, Michel, Hedner, Thomas, Kjeldsen, Sverre, Wahlstrand, Björn, Sjögren, Marketa, Fava, Cristiano, Montagnana, Martina, Danese, Elisa, Torffvit, Ole, Hedblad, Bo, Snieder, Harold, Connell, John M. C., Brown, Morris, Samani, Nilesh J., Farrall, Martin, Cesana, Giancarlo, Mancia, Giuseppe, Signorini, Stefano, Grassi, Guido, Eyheramendy, Susana, Wichmann, H. Erich, Laan, Maris, Strachan, David P., Sever, Peter, Shields, Denis Colm, Stanton, Alice, Vollenweider, Peter, Teumer, Alexander, Völzke, Henry, Rettig, Rainer, Newton-Cheh, Christopher, Arora, Pankaj, Zhang, Feng, Soranzo, Nicole, Spector, Timothy D., Lucas, Gavin, Kathiresan, Sekar, Siscovick, David S., Luan, Jian'an, Loos, Ruth J. F., Wareham, Nicholas J., Penninx, Brenda W., Nolte, Ilja M., McBride, Martin, Miller, William H., Nicklin, Stuart A., Baker, Andrew H., Graham, Delyth, McDonald, Robert A., Pell, Jill P., Sattar, Naveed, Welsh, Paul, Munroe, Patricia, Caulfield, Mark J., Zanchetti, Alberto, Dominiczak, Anna F.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 28.10.2010 Public Library of Science (PLoS)
Predmet:	Age Aged Alleles Blood Pressure Body mass index burden Cardiology and Cardiovascular Disease Cardiovascular Disorders/Hypertension Chromosomes, Human, Pair 16 - genetics chronic kidney-disease Clinical Medicine Confidence intervals feasibility Female Gene Frequency Genetic Predisposition to Disease Genetics and Genomics/Complex Traits Genetics and Genomics/Genetics of Disease Genome-Wide Association Study - methods Genome-Wide Association Study - statistics & numerical data Genomes Genotype Glomerular Filtration Rate Health risk assessment Heart attacks Humans Hypertension - genetics Hypertension - physiopathology Kardiologi och kardiovaskulära sjukdomar Klinisk medicin Linear Models loci Male Medical and Health Sciences Medicin och hälsovetenskap Meta-Analysis as Topic Middle Aged Mortality Multivariate Analysis mutations nephropathy Polymorphism, Single Nucleotide Population Proportional Hazards Models Risk assessment Risk Factors Studies Survival Analysis tamm-horsfall protein urinary-excretion Uromodulin - blood Uromodulin - genetics
ISSN:	1553-7404, 1553-7390, 1553-7404
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