An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse

Preclinical CT-guided radiotherapy platforms are increasingly used but the CT images are characterized by poor soft tissue contrast. The aim of this study was to develop a robust and accurate method of MRI-guided radiotherapy (MR-IGRT) delivery to abdominal targets in the mouse. A multimodality crad...

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Bibliographic Details
Published in:	PloS one Vol. 12; no. 4; p. e0176693
Main Authors:	Kersemans, Veerle, Beech, John S., Gilchrist, Stuart, Kinchesh, Paul, Allen, Philip D., Thompson, James, Gomes, Ana L., D’Costa, Zenobia, Bird, Luke, Tullis, Iain D. C., Newman, Robert G., Corroyer-Dulmont, Aurelien, Falzone, Nadia, Azad, Abul, Vallis, Katherine A., Sansom, Owen J., Muschel, Ruth J., Vojnovic, Borivoj, Hill, Mark A., Fokas, Emmanouil, Smart, Sean C.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 28.04.2017 Public Library of Science (PLoS)
Subjects:	Abdomen - diagnostic imaging Abdomen - radiation effects Abdominal cancer Abdominal Neoplasms - diagnostic imaging Abdominal Neoplasms - radiotherapy Adenocarcinoma Adrenal glands Adrenal Glands - diagnostic imaging Adrenal Glands - radiation effects Animals Beams (radiation) Biology and Life Sciences Care and treatment Cell Line, Tumor Charities Cognitive science Computed tomography Contour matching Contouring Dosimetry Glands Health aspects Health risk assessment Health risks House mouse Humans Image contrast Immobilization In vitro methods and tests In vivo methods and tests Magnetic resonance imaging Magnetic Resonance Imaging - instrumentation Magnetic Resonance Imaging - methods Medical research Medicine and Health Sciences Mice, Inbred BALB C Mice, Inbred CBA Mice, Inbred NOD Mice, Nude Mice, Transgenic Motion Motion stability Multimodal Imaging - instrumentation Neoplasm Transplantation Neuroblastoma Neuroscience Organs Pancreas Pancreatic cancer Phantoms, Imaging Radiation Radiation dosage Radiation therapy Radiometry - instrumentation Radiotherapy Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - instrumentation Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Image-Guided - instrumentation Radiotherapy, Image-Guided - methods Regression models Research and Analysis Methods Robustness (mathematics) Soft tissues Stability tests Tomography, X-Ray Computed - instrumentation Tomography, X-Ray Computed - methods Tumor Burden Tumors Xenografts Xenotransplantation
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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