Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study

Head and neck squamous cell carcinoma (HNSCC), which includes cancers of the oral cavity and oropharynx, is a cause of substantial global morbidity and mortality. Strategies to reduce disease burden include discovery of novel therapies and repurposing of existing drugs. Statins are commonly prescrib...

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Bibliographic Details
Published in:	PLoS genetics Vol. 17; no. 4; p. e1009525
Main Authors:	Gormley, Mark, Yarmolinsky, James, Dudding, Tom, Burrows, Kimberley, Martin, Richard M., Thomas, Steven, Tyrrell, Jessica, Brennan, Paul, Pring, Miranda, Boccia, Stefania, Olshan, Andrew F., Diergaarde, Brenda, Hung, Rayjean J., Liu, Geoffrey, Legge, Danny, Tajara, Eloiza H., Severino, Patricia, Lacko, Martin, Ness, Andrew R., Davey Smith, George, Vincent, Emma E., Richmond, Rebecca C.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 22.04.2021 Public Library of Science (PLoS)
Subjects:	Biology and Life Sciences Cancer therapies Cardiovascular disease Cell cycle Cell division Cell migration Cholesterol Cholesterol - biosynthesis Cholesterol - genetics Cholesterol Ester Transfer Proteins - genetics Cholesterol, LDL - antagonists & inhibitors Cholesterol, LDL - genetics Cholesteryl ester transfer protein Coenzyme A Consortia Diabetes Drugs Genetic aspects Genetic diversity Genetic Predisposition to Disease Genetic variation Genome-Wide Association Study Germ-Line Mutation - genetics Head & neck cancer Head and neck cancer Health aspects High density lipoprotein Human papillomavirus Humans Hydroxymethylglutaryl CoA Reductases - drug effects Hydroxymethylglutaryl CoA Reductases - genetics Hydroxymethylglutaryl-CoA reductase Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Lipids Low density lipoprotein Medicine and Health Sciences Membrane proteins Membrane Transport Proteins - genetics Mendelian Randomization Analysis Mevalonate pathway Mevalonic acid Ovarian cancer Physiological aspects Principal components analysis Proprotein Convertase 9 - genetics Protein biosynthesis Proteins Proxies Receptors, LDL - genetics Risk factors Signal transduction Squamous Cell Carcinoma of Head and Neck - drug therapy Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - pathology Statins United Kingdom
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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