Chromosome-wide co-fluctuation of stochastic gene expression in mammalian cells

Gene expression is subject to stochastic noise, but to what extent and by which means such stochastic variations are coordinated among different genes are unclear. We hypothesize that neighboring genes on the same chromosome co-fluctuate in expression because of their common chromatin dynamics, and...

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Bibliographic Details
Published in:	PLoS genetics Vol. 15; no. 9; p. e1008389
Main Authors:	Sun, Mengyi, Zhang, Jianzhi
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 16.09.2019 Public Library of Science (PLoS)
Subjects:	Analysis Animals Biology and Life Sciences Cell cycle Chromatin Chromatin - genetics Chromosome abnormalities Chromosome Mapping - methods Chromosomes Chromosomes - genetics Databases, Genetic Evolution Evolution, Molecular Evolutionary biology Gene expression Gene Expression - genetics Gene Expression Regulation - genetics Genetic aspects Genetic Linkage - genetics Genome - genetics Genomes Genomics - methods House mouse Humans Hypotheses Mammalian cells Mammals - genetics Mice Natural selection Proteins Ribonucleic acid RNA Selection, Genetic Stochastic models Stochastic Processes Stochasticity Yeast United States Ann Arbor Michigan United States > US
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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