Characterising the Inhibitory Actions of Ceramide upon Insulin Signaling in Different Skeletal Muscle Cell Models: A Mechanistic Insight

Ceramides are known to promote insulin resistance in a number of metabolically important tissues including skeletal muscle, the predominant site of insulin-stimulated glucose disposal. Depending on cell type, these lipid intermediates have been shown to inhibit protein kinase B (PKB/Akt), a key medi...

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Vydané v:	PloS one Ročník 9; číslo 7; s. e101865
Hlavní autori:	Mahfouz, Rana, Khoury, Rhéa, Blachnio-Zabielska, Agnieszka, Turban, Sophie, Loiseau, Nicolas, Lipina, Christopher, Stretton, Clare, Bourron, Olivier, Ferré, Pascal, Foufelle, Fabienne, Hundal, Harinder S., Hajduch, Eric
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 24.07.2014 Public Library of Science (PLoS)
Predmet:	AKT protein Animal models Animals Biology and Life Sciences Caveolin Caveolins - genetics Caveolins - metabolism Cell culture Cellular signal transduction Ceramide Ceramides Ceramides - pharmacology Composition effects Diabetes mellitus Gene Expression Regulation Glucose Human health and pathology Humans Insulin Insulin - metabolism Insulin - pharmacology Insulin resistance Intermediates Isoforms Kinases Life Sciences Membrane composition Mice Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - metabolism Muscle, Skeletal - cytology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscles Myotubes Palmitic acid Phosphoprotein phosphatase Plant lipids Primary Cell Culture Protein kinase C Protein Kinase C - genetics Protein Kinase C - metabolism Protein phosphatase Protein Phosphatase 2 - genetics Protein Phosphatase 2 - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rats Rodents Signal transduction Signal Transduction - drug effects Signaling Skeletal muscle Tissues United Kingdom > UK France
ISSN:	1932-6203, 1932-6203
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