The Impact of the Duration of Adjuvant Chemotherapy on Survival in Patients with Epithelial Ovarian Cancer – A Retrospective Study

The aim of the present study was to investigate the prognostic role of the duration of adjuvant chemotherapy in patients with epithelial ovarian, fallopian tube and primary peritoneal cancer (EOC). Within the present study we retrospectively evaluated the data of 165 consecutive patients with EOC tr...

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Veröffentlicht in:PloS one Jg. 12; H. 1; S. e0169272
Hauptverfasser: Seebacher, Veronika, Reinthaller, Alexander, Koelbl, Heinz, Concin, Nicole, Nehoda, Regina, Polterauer, Stephan
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 06.01.2017
Public Library of Science (PLoS)
Schlagworte:
Adjuvant chemotherapy
Antineoplastic Combined Chemotherapy Protocols
Biology and Life Sciences
Breast cancer
Cancer
Cancer therapies
Carcinoma, Ovarian Epithelial
Care and treatment
Chemotherapy
Chemotherapy, Adjuvant - methods
Cisplatin - therapeutic use
Clinical medicine
Comparative analysis
Confidence intervals
Delay
Disease-Free Survival
Docetaxel
Fallopian tube
Female
Gastric cancer
Gynecology
Health aspects
Humans
Intravenous administration
Medicine and Health Sciences
Multivariate Analysis
Neoplasms, Glandular and Epithelial - drug therapy
Neoplasms, Glandular and Epithelial - surgery
Obstetrics
Oncology
Ovarian cancer
Ovarian carcinoma
Ovarian Neoplasms - drug therapy
Ovarian Neoplasms - surgery
Patient outcomes
Patients
Peritoneal Neoplasms - drug therapy
Peritoneum
Physical Sciences
Platinum
Prognosis
Proportional Hazards Models
Research and Analysis Methods
Retrospective Studies
Risk groups
Stomach cancer
Surgery
Survival
Taxoids - therapeutic use
Womens health
ISSN:1932-6203, 1932-6203
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Zusammenfassung:The aim of the present study was to investigate the prognostic role of the duration of adjuvant chemotherapy in patients with epithelial ovarian, fallopian tube and primary peritoneal cancer (EOC). Within the present study we retrospectively evaluated the data of 165 consecutive patients with EOC treated with primary surgery followed by six completed cycles of platinum-taxan based intravenous adjuvant chemotherapy. Medians of total duration of chemotherapy were compared with clinical-pathological parameters. Patients were stratified into four risk groups according to the delay in days of total duration of chemotherapy, and univariate and multivariable survival analyses were performed. The median duration of six completed cycles of chemotherapy comprised 113 days (IQR 107-124 days). Uni- and multivariable survival analyses revealed a delay of total duration of chemotherapy of at least 9 days to be associated with progression-free (PFS), cancer-specific (CSS) and overall survival (OS). Hazard ratios (HR), confidence intervals (95% CI) and p-values for PFS, CSS and OS due to delay of chemo-duration were 2.9 (1.6-5.4; p = 0.001), 2.9 (1.3-6.2; p = 0.008) and 2.6 (1.3-5.4; p = 0.008), respectively. Prolonged total chemo-duration was associated with the amount of postoperative residual disease (p = 0.001) and the patients' age (p = 0.03). The present study suggests a prolonged duration of adjuvant chemotherapy after primary surgery to adversely affect PFS, CSS and OS in patients with EOC. Yet larger studies are required to validate our results.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Conceptualization: VS SP AR HK NC RN.Data curation: VS RN SP.Formal analysis: VS SP.Investigation: VS RN NC SP.Methodology: VS SP NC.Project administration: VS SP.Resources: VS AR HK.Supervision: AR HK NC SP.Writing – original draft: VS SP NC.Writing – review & editing: VS AR HK RN NC SP.
Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0169272